Also available as PDF (figures and tables appear in the PDF).
Abstract
In many countries, rice contributes to health by supplying dietary energy, proteins and fat. Many different species of rice have been developed in Japan and other rice producing countries. Some varieties are expected to prevent various diseases, or to be used for dietary therapy. The health effects of brown rice are empirically well known, and accumulating evidence about the physiological and pharmacological activity of rice bran strongly supports the use of brown rice in the dietary therapy. These could be categorized in the new concept, “medical rice”. For example: medical rice for diabetes (glycemic index<55), medical rice for chronic kidney dis-ease (CKD) (protein<1/20), medical rice for mental health (high gamma-aminobutylic acid or γ-aminobutylic acid (GABA), gamma oryzanol (γ-oryzanol) and/or ferulic acid), and medical rice for cancer prevention (high antioxidant capacity). Organic cultivation is necessary to avoid toxic substances from fertilizers and insecticides. In response to the enormous increase of med-ical costs in many countries, encouragement of healthy longevity by changes of dietary habits is mandatory. Functional food labeling has started in 2015 in Japan, so the proper food labeling of medical rice could help people who want to control and/or improve their health status.
Keywords: Brown rice; Rice bran; Rice ingredients; Glycemic index; Low protein rice; Gamma-aminobutylic acid or γ-aminobutylic acid (GABA); γ-oryzanol; Ferulic acid; Phytate
Conclusion
The health effects of brown rice are empirically well known, and accumulating evidence about the physiological and pharmacological activity of rice bran strongly supports the use of brown rice in meals, although this is not popular in Japan and other countries. However, in response to the enormous increase of medical costs, the Japanese government starts to encourage
Raw brown rice Raw brown rice Raw brown rice Cooked brown rice by pressure pan Cooked brown rice by pressure pan Cooked brown rice by pressure pan Cooked brown rice without pressure Cooked brown rice without pressure Cooked brown rice without pressure Pregerminated rice Pregerminated rice Cooked polished rice “kinme” Cooked polished rice “kinme” Cooked polished rice “kinme” cooked polished white rice cooked polished white rice cooked polished white rice AOU-F: Antioxidant unit by flavonoids; AOU-C: Antioxidant unit like carotenoids.
Table 5. Antioxidantactivity of various rice and cooked rice. These rice with high antioxidant activity could be categorized in the medical rice for cancer prevention.
Figure 9. Food labeling of medical rice and licensed medical rice for health. This rice is organic brown rice, containing enough vitamins and minerals with high antioxidant ability, without any detectable herbicide or toxic heavy metals.
healthy longevity measures by changes of dietary habits. Functional food labeling has started in 2015, so the proper food labeling of medical rice could help people who want to control and/ 66 44 or improve their health status.44 An example of food label for ‘Medical Rice for Health’ is shown in the figure (Figure 9).
A word in the lower part of the mark could be changed according to the purpose.
Acknowledgements
The authors deeply appreciate the participants in the East Asia Conference of Standardization of Rice Function, which was held in Kyoto from December 10 to 12, 2014. All authors attended the conference and contributed to make the entity of medical rice, providing their original data.
The authors also thank the financial support of Human Health Foundation, Toyo Rice Cooperation, Tsuno Rice Fine Chemicals Co, Ltd. Fancl Cooperation, Genmai-koso Co. Ltd, and Forica Food Co. Ltd. to open this conference. A part of this work was th presented at the 9th Asia Pacific Conference on Clinical Nutrition, which was held in Kuala Lumpur, Malaysia in 2015. They also thank to Dr. Philippe Calain for his contribution to complete this manuscript.
Conflicts Of Interest
The authors do not have any conflicts of interest regarding this paper to any company.
References
VanavichitA. Facts about rice. In: Sontag J, ed. Rice Processing: The Comprehensive Guide to Global Technology and Innovative Products. ERLING, Germany: Verlag GmbH & Co. KG; 2014: 11-24
FAOSTAT. Final 2012 data and preliminary 2013 data for 5 major commodity aggregates. Web site. http://faostat.fao.org/ site/339/default.aspx. Accessed July 13, 2016
WatanabeS. Principles of Nutritional Science. Tokyo, Japan: Nanko-do Co. Ltd.; 2011
UdagawaKMiyoshiMYoshiikeN. Mid-term evaluation of “Health Japan 21”: Focus area for the nutrition and diet. Asia Pac J Clin Nutr. 2008; 17(S2): 445-452. doi: 10.6133/apjcn.2008.17. s2.0810.6133/apjcn.2008.17.s2.08 https://doi.org/10.6133/apjcn.2008.17.s2.08
JushiMJackA. The Macrobiotic Path to Total Health. New York, USA: Ballantine Books; 2004
IshidaE. Genmai-Brown Rice for Better Health. Tokyo, Japan: Japan Pub Inc.; 1989
KushiLHByersTDoyleC. American Cancer Society guidelines on nutrition and physical activity for cancer prevention: Reducing the risk of cancer with healthy food choices and physical activity. CA Cancer J Clin. 2006; 56: 254-281. doi: 10.3322/canjclin.56.5.25410.3322/canjclin.56.5.254 https://doi.org/10.3322/canjclin.56.5.254
WHFoods. Brown Rice. 2012. Web site. http://www.whfoods. com/genpage.php?tname=foodspice&dbid=128. Accessed July 13, 2016
Tsukuba Agriculture Research Gallery. Rice Studies, Present and Future. Tokyo, Japan: Sankyo Pub Co. Ltd.; 2012: 316-336
SmitHJKemsleyEKTappHSHenryCJK. Does prolonged chewing reduce food intake? Fletcherism revisited. Appetite. 2011; 57: 295-298. Web site. http://www.ifr.ac.uk/research/publications/307/does-prolonged-chewing-reduce-foodintake-fletcherism-revisited/. Accessed July 13, 2016
OgawaS. Rice Studies, Present and Future: In Commemoration of Second International Symposium on Rice and Disease Prevention. Tokyo, Japan: Sankyo Pub. Co. Ltd.; 2012
JulianoBOBoulterD. Extraction and composition of rice endosperm glutenin. Phytochemistry. 1985; 15: 1601-1606. doi: 10.1016/S0031-9422(00)97436-310.1016/s0031-9422(00)97436-3 https://doi.org/10.1016/s0031-9422(00)97436-3
NakagamiTGondaHHashimotoHTsunoT. LC/MS analysis of cerebrosides in rice bran. In: Tsukuba Agriculture Research Gallery, ed. Rice Studies, Present and Future. Tokyo, Japan: Sankyo Pub Co. Ltd.; 2012: 225-232
WatanabeS. Proceedings of the East Asia Conference on Standardization of Rice Function. Kyoto, Japan: Lifescience Promoting Organization. 2013
MostMMTulleyRMoralesSLefevreM. Rice bran oil, not fiber, lowers cholesterol in humans. Am J Clin Nutr. 2005; 81(1): 64-68. Web site. http://ajcn.nutrition.org/content/81/1/64. long. Accessed July 13, 2016
SuganoM. Functional characteristics of rice bran oil. Shokkuhin Kako Gijutu. J Jpn Soc Food Engineering. 2002; 22: 26- 30
TianSNakamuraKCuiTKayaharaHJ. High-performance liquid chromatographic determination of phenolic compounds in rice. J Chromatogr A. 2005; 1063(1-2): 121-128
TianSNakamuraKKayaharaH. Analysis of phenolic compounds in white rice, brown rice, and germinated brown rice. J Agric Food Chem. 2004; 52: 4808-4813. doi: 10.1021/jf049446f10.1021/jf049446f https://doi.org/10.1021/jf049446f
MiyazawaTSibataANakagawaKPhumonS. Cancer prevention by rice bran tocotrienol. In: Tsukuba Agriculture Research Gallery, ed. Rice Studies, Present and Future. Tokyo, Japan: Sankyo Pub Co. Ltd.; 2012: 217-224
MoritaNMaedaT. Gamma-aminobutyric acid and functional materials in brown rice and psudo-cereal during germination and their applications to food processing. In: Tsukuba Agriculture Research Gallery, ed. Rice Studies, Present and Future. Tokyo, Japan: Sankyo Pub Co. Ltd.; 2012: 150-161
DilworthLOmoruyiFAsemotaH. Effects of IP6 on carbogydrate and lipid metabolism in rat model. In: Tsukuba Agriculture Research Gallery, ed. Rice Studies, Present and Future. Tokyo, Japan: Sankyo Pub Co. Ltd.; 2012: 162-143
GrasesFCosta-bauzaAPrietoRM. Phytate as modulator of calcification processes in humans. In: Tsukuba Agriculture Research Gallery, ed. Rice Studies, Present and Future. Tokyo, Japan: Sankyo Pub Co. Ltd.; 2012: 167-177
VucenikI. IP6 and inositol in cancer prevention and therapy. In: Tsukuba Agriculture Research Gallery, ed. Rice Studies, Present and Future. Tokyo, Japan: Sankyo Pub Co. Ltd.; 2012: 196-208
MaebaRHaraH. Myo-Inositol and plasmalogens. In: Tsukuba Agriculture Research Gallery, ed. Rice Studies, Present and Future. Tokyo, Japan: Sankyo Pub Co. Ltd.; 2012: 178-188
SzaboE. Myo-inositol and the prevention of lung cancer. In: Tsukuba Agriculture Research Gallery, ed. Rice Studies, Present and Future. Tokyo, Japan: Sankyo Pub Co. Ltd.; 2012: 189-195
BenjaminJLevineJFuxMAvivALevyDBelmakerRH. Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder. Am J Psychiatry. 1995; 152(7): 1084-1086. doi: 10.1176/ajp.152.7.108410.1176/ajp.152.7.1084 https://doi.org/10.1176/ajp.152.7.1084
TungtrakulP. Innovative rice products in Thailand. Proceedings of the East Asia Conference on Standardization of Rice Function. Kyoto, Japan. 2013; 61-62
MuranVSpiegelmanDSadhaV. Effect of brown rice, white rice, and brown rice with legumes on blood glucose and insulin responses in overweight Asian Indians: A randomized control trial. Diabetes Technol Ther. 2014; 16: 317-325. doi: 10.1089/dia.2013.025910.1089/dia.2013.0259 https://doi.org/10.1089/dia.2013.0259
OhtsuboKNakamuraS. Tsuji K, Utsunomiya K, Masuda Y, Hasegawa M. Possibility of diabetes prevention by high amylose rice. In: Tsukuba Agriculture Research Gallery, ed. Rice Studies, Present and Future. Tokyo, Japan: Sankyo Pub Co. Ltd.; 2012: 109-115
KadowakiMWatanabeRKubotaMKuragaiTMasumuraT. Digestibility, bioavailability, and beneficial effects of alkaliextracted rice protein. In: Tsukuba Agriculture Research Gallery, ed. Rice Studies, Present and Future. Tokyo, Japan: Sankyo Pub Co. Ltd.; 2012: 123-135
BeppuS. Low Protein Processing Cooked Rice. Proceedings East Asia Conference on Standardization of Rice Function. Kyoto, Japan. 2014; 33-34
YokoyamaWHOhtsuboKBartleyGSuzukiK. Health benefits of pre-geminated rice and recent studies of hamsters fed PGR. In: Tsukuba Agriculture Research Gallery, ed. Rice Studies, Present and Future. Tokyo, Japan: Sankyo Pub Co. Ltd
KosakaHNemotoHMotojimaA. Antitumorigenic effect and antioxidative activity of the brown rice fermented by aspergillus oryzae (FBRA). In: Tsukuba Agriculture Research Gallery, ed. Rice Studies, Present and Future. Tokyo, Japan: Sankyo Pub Co. Ltd.; 2012: 266
GrantBLHamiltonKK. Medical nutrition therapy for cancer prevention, treatment, and recovery. In: Mahan LK, Escot-Stump S, Raymond JL, eds. Krause’s Food and the Nutrition th Care Process. 13th ed. St. Louis, USA: Elsevier; 2012: 832-863
HuEAPanAMalikVSunQ. White rice consumption and risk of type 2 diabetes: Meta-analysis and systematic review. BMJ. 2012; 344: e1454. doi: 10.1136/bmj.e145410.1136/bmj.e1454 https://doi.org/10.1136/bmj.e1454
ShimabukuroMMasuzakiHRieK. Effects of brown rice diet on visceral obesity and endothelial function: The BRAVO study. British J Nut. 2013; 111: 310-320. doi: 10.1017/ S0007114513002432
NakamuraSSatohHOhtsuboK. Characteristics of pregelatinized ae mutant rice flours prepared by boiling after preroasting. J Agric Food Chem. 2011; 59(19): 10665-10676. doi: 10.1021/jf200973x10.1021/jf200973x https://doi.org/10.1021/jf200973x
NakamuraSSatohHOhtsuboK. Palatable and bio-functional wheat/rice bread from pre-germinated brown rice of super hard cultivar, EM10. Biosci Biotechnol Biochem. 2010; 74(6): 1164-1117. doi: 10.1271/bbb.9085010.1271/bbb.90850 https://doi.org/10.1271/bbb.90850
NakamuraSOhtsuboK. Acceleration of germination of super-hard rice cultivar EM10 by soaking with red onion. Biosci Biotechnol Biochem. 2011; 75(3): 572-574. doi: 10.1271/ bbb.100621
KoppleJDMassrySG. Nutritional Management of Renal Disease. Baltimore, Maryland, USA: Williams & Wilkins; 1997
WatanabeS. Recipe of Low Protein Diet to keep Kidney Function. Tokyo, Japan: Shufu-no-tomo-sha; 2010
MasumuraTSaitoY. Structure and function of rice seed protein. In: Tsukuba Agriculture Research Gallery, ed. Rice Studies, Present and Future. Tokyo, Japan: Sankyo Pub Co. Ltd.; 2012: 144-149
MizunoS. A secondary analysis of ideura data of low protein diet practice for progressive chronic kidney disease patients. Clin Funct Nutriol. 2009; 1(5): 242-245
Sun J-Q, Wang Y. Effects of low-protein rice on nutrition status and renal function in patients with chronic kidney disease: ization of Rice Function. 2014; 49-50
KoppleJELeveyAGreeneT. Effect of dietary protein restriction on nutritional status in the modification of diet in renal disease study. Kidney Int. 1997; 52: 778-791. doi: 10.1038/ ki.1997.395
WatanabeS. Evaluation of modification of diet in renal disease (MDRD) Study. Clin Funct Nutriol. 2009; 1(5): 238-241
WHO. Dementia: Fact Sheet. 2016. Web site. http://www.who. int/mediacentre/factsheets/fs362/en/. Accessed July 13, 2016
TahiraT. Prevention of dementia by improving life style. Clin Funct Nutriol. 2012; 4(6): 296-301
KimuraT. Ferulic acid and angelica archangelica extract in dementia: Effects upon cognitive efunctions and behavioral and psychologic symptoms of dementia. Proceedings East Asia Conference on Standardization of Rice Function. 2014; 75
Bui TN, Nguyen do H, Tran QB, et al. Pre-germinted brown rice reduced both blood glucose concentration and body weight in Vietnamese women with impaired glucose tolerance. Proceedings East Asia Conference on Standardization of Rice Function. 2014; 45-46
ShoichiIYukihiroI. Marketing of Value-Add Rice Products in Japan: Germinated Brown Rice and Rice Bread. Symposium, Rome: FAO International; 2004
KimuraTHayashidaHMurataMTakamatsuJ. Effect of ferulic acid and angelica archangelica extract on behavioral and psychological symptoms of dementia in frontotemporal lobar degeneration and dementia with Lewy bodies. Geriatr Geront Int. 2011; 11: 309-314. Web site. http://www.citeulike.org/user/ applebyb/author/Kimura:T. Accessed July 13, 2016
SakomotoSHayashiTHayashiK. Pre-germinated brown rice could enhance maternal mental health and immunity during lactation. Eur J Nutr. 2007; 46: 391-396. doi: 10.1007/ s00394-007-0678-3
MatsushitaKArakiEKawaseSSunoharaYIidaS. Haiibuki, a rice variety with giant embryo, accumulates high amount of GABA. In: Tsukuba Agriculture Research Gallery, ed. Rice Studies, Present and Future. Tokyo, Japan: Sankyo Pub Co. Ltd.; 2012: 314
MoriH. Cancer prevention by rice and rice bran. Clin Funct Nutriol. 2013; 5(3): 126-129
TomitaHKunoTYamadaY. Preventive effect of fermented brown rice and rice bran on N-methyl-N’-nitro-Nnitrosoguanidine-induced gastric carcinogenesis. Oncol Report. 2008; 19(1): 11-15. doi: 10.3892/or.19.1.1110.3892/or.19.1.11 https://doi.org/10.3892/or.19.1.11
KatayamaMYoshimiNYamadaY. Preventive effect of fermented brown rice and rice bran against colon carcinogenesis in male F344 rats. Oncol Report. 2002; 9(4): 817-822. doi: 10.3892/or.9.4.81710.3892/or.9.4.817 https://doi.org/10.3892/or.9.4.817
PriorRLHoangHGuL. Assays for hydrophilic and lipophilic antioxidant capacity (oxygen radical absorbance capacity (ORAC(FL))) of plasma and other biological and food samples. J Agric Food Chem. 2003; 51: 3273-3279. doi: 10.1021/jf026225610.1021/jf0262256 https://doi.org/10.1021/jf0262256
PriorRLWuXSchaichK. Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements. J Agric Food Chem. 2005; 53: 4290-4302. doi: 10.1021/jf050269810.1021/jf0502698 https://doi.org/10.1021/jf0502698
Serafini M, Del Rio D. Understanding the association between dietary antioxidants, redox status and disease: Is the total antioxidant capacity the right tool? Redox Rep. 2004; 9: 145- 152. doi: 10.1179/135100004225004814 https://doi.org/10.1179/135100004225004814
TakebayashiJOkiTChenJ. Estimated average daily intake of antioxidants from typical vegetables consumed in Japan: A preliminary study. Biosci Biotechnol Biochem. 2010; 74: 2137-2140. doi: 10.1271/bbb.10043010.1271/bbb.100430 https://doi.org/10.1271/bbb.100430
Tatsumi Y, Ishihara J, Morimoto M, Ohno Y, Watanabe S for the JPHC FFQ Validation Study Group. Seasonal differences in total antioxidant capacity intake from foods consumed by a Japanese population. Eur J Clin Nutr. 2014; 68(7): 799-803. doi: 10.1038/ejcn.2014.65 https://doi.org/10.1038/ejcn.2014.65
HirakawaAWatanabeSIzumiYNishiumiSYamadaM. Brown rice is the complete meal. Anti Aging Med. 2012; 8(4): 585-591