Brain Mechanisms in Blood Glucose Mobilization and Absorption: The Role of the Left and the Right Frontal Regions in the Regulatory Control of Blood Glucose Levels

Crossmark: check for updates

Authors

  • Benjamin B. DeVore Department of Psychology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
  • David W. Harrison Department of Psychology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA

DOI:

https://doi.org/10.17140/DROJ-3-131

Abstract

With the ravaging effects of glucose related diseases (such as diabetes) on the rise, an increased understanding of the central mechanisms involved in glucose mobilization and absorption, and the potential development of the metabolic syndrome, is becoming increasingly important. Although, substantive efforts have been expended to better understand the peripheral mechanisms involved with the systemic processing of glucose, there remains a paucity of research dedicated to the central neural aspects largely involved in the mobilization and absorption of blood glucose. Despite this lack of research, the relationship between emotional states of anger or fear and those oppositional processes associated with quiescent states or digestive uptake have been clearly related to blood glucose levels.1-3 Moreover, and perhaps most relevant here, is that the differential emotional states just described have been established with origins in cerebral laterality and with regulatory control mechanisms largely relegated to the frontal lobes and executive brain systems.

References

Cox DJ, Taylor AG, Nowacek G, Holley-Wilcox P, Pohl SL, Guthrow E. The relationship between psychological stress and insulin-dependent diabetic blood glucose control: Prelimi-nary investigations. Health Psychol. 1984; 3(1): 63-75. doi: 10.1037/0278-6133.3.1.63

Walters RP, Harrison PK, Campbell RW, Harrison DW. Fron-tal lobe regulation of blood glucose levels: Support for the limit-ed capacity model in hostile violence-prone men. Brain Inform. 2016; 3(4): 221-231. doi: 10.1007/s40708-016-0034-6

Walters RP, Harrison PK, DeVore BB, Harrison DW. Capac-ity theory: A neuropsychological perspective on shared neu-ral systems regulating hostile violence prone behavior and the metabolic syndrome. Austin J Neurological Disorders Epilepsy. 2016; 3(1): 1014-1030. Web site. http://austinpublishinggroup. com/neurological-disorders-epilepsy/fulltext/ajnde-v3-id1014. php. Accessed February 14, 2017.

Cox DE, Harrison DW. Models of anger: Contributions from psychophysiology, neuropsychology and the cognitive behav-ioral perspective. Brain Struct Funct. 2008; 212(5): 371-385. doi: 10.1007/s00429-007-0168-7

Davidson RJ, Putnam KM, Larson CL. Dysfunction in the neural circuitry of emotion regulation--a possible prelude to violence. Science. 2000; 289(5479): 591-594. doi: 10.1126/sci-ence.289.5479.591

Harrison DW. Frontal Lobe Syndromes. In: Brain Asymmetry and Neural Systems. Berlin, Germany: Systems Springer Inter-national Publishing; 2015: 267-321.

Demaree HA, Everhart DE, Youngstrom EA, Harrison DW. Brain lateralization of emotional processing: Historical roots and a future incorporating “dominance”. Behav Cogn Neurosci Rev. 2005; 4(1): 3-20. Web site. http://journals.sagepub.com/doi/ abs/10.1177/1534582305276837. Accessed February 14, 2017.

Harrison DW. Positive and Negative Emotion. In: Brain Asymmetry and Neural Systems. Berlin, Germany: Springer In-ternational Publishing; 2015: 389-413.

Harrison DW. Parasympathetic and Sympathetic Tone. In: Brain Asymmetry and Neural Systems. Berlin, Germany: Spring-er International Publishing; 2015: 441-453.

Heilman KM, Schwartz H, Watson RT. Hypoarousal in pa-tients with the neglect syndrome and emotional indifference. Neurology. 1978; 28(3): 229-232. doi: 10. 1212/ WNL. 28. 3. 229

Carmona JE, Holland AK, Harrison DW. Extending the functional cerebral systems theory of emotion to the vestibular modality: A systematic and integrative approach. Psychol Bull. 2009; 135(2): 286-302. doi: 10.1037/a0014825

Luria AR. Higher Cortical Functions in Man. New York, USA: Basic Books; 1966.

Luria AR. The Working Brain: An Introduction to Neuropsy-chology. New York, USA: Basic Books, Inc., Publishers; 1973.

Luria AR. Higher Cortical Functions in Man. 2nd ed. New York, USA: Basic Books, Inc., Publishers; 1980.

Heilman KM, Bowers D, Valenstein E. Emotional disorders associated with neurological diseases. Clinical neuropsychol-ogy. 1993; 3: 461-97.

Holland AK, Carmona JE, Harrison DW. An exten-sion of the functional cerebral systems approach to hostil-ity: A capacity model utilizing a dual concurrent task para-digm. J Clin Exp Neuropsychol. 2012; 34(1): 92-106. doi: 10.1080/13803395.2011.623119

Oppenheimer SM, Gelb A, Girvin JP, Hachinski VC. Cardio-vascular effects of human insular cortex stimulation. Neurology. 1992; 42(9): 1727-1727. doi: 10. 1212/ WNL.42. 9. 1727

Hilz MJ, Dütsch M, Perrine K, Nelson PK, Rauhut U, Devin-sky O. Hemispheric influence on autonomic modulation and baroreflex sensitivity. Ann Neurol. 2001; 49(5): 575-584. doi: 10.1002/ana.1006

Comer CS, Harrison PK, Harrison DW. The dynamic oppo-nent relativity model: An integration and extension of capacity theory and existing theoretical perspectives on the neuropsy-chology of arousal and emotion. Springerplus. 2015; 4(1): 345. doi: 10.1186/s40064-015-1120-6

Wittling W, Block A, Genzel S, Schweiger E. Hemisphere asymmetry in parasympathetic control of the heart. Neuro-psychologia. 1998; 36(5): 461-468. doi: 10.1016/S0028- 3932(97)00129-2

Peyrot MF, McMurry JF. Stress buffering and glycemic con-trol: The role of coping styles. Diabetes care. 1992; 15(7): 842- 846. doi: 10.2337/diacare.15.7.842

Published

2017-04-19

How to Cite

Benjamin B. DeVore, & David W. Harrison. (2017). Brain Mechanisms in Blood Glucose Mobilization and Absorption: The Role of the Left and the Right Frontal Regions in the Regulatory Control of Blood Glucose Levels. Diabetes Research, 3(2), 17–19. https://doi.org/10.17140/DROJ-3-131