West Virginia University Medicine, Wheeling Hospital’s Sepsis Study

Abstract

Aims
To assess if sepsis bundle compliance is associated with all-cause mortality reduction in severe sepsis and septic shock patients.
Methods
The study focused on adults 18-years and older with a diagnosis of severe sepsis or septic shock.
Results
The final study cohort consists of 2356 patients who met the inclusion criteria, and close to 76% of the study cohort confirmed compliance with the sepsis bundle. The computed mortality rates for the compliant cohort and non-compliant cohort were 12.3% and 23.6%, respectively (p=1.8×10-6). Is this p-value below 0.05?
Conclusion
We demonstrated that sepsis bundle compliance is strongly associated with a reduction in all-cause mortality. Importantly, it will be useful to identify further the specific bundle component with the strongest mortality reduction benefit.