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Heterotopic pregnancy is a rare gynaecological condition whereby there is a presence of an intrauterine pregnancy and extrauterine pregnancy at the same time. It was first defined by Duverney in 1708 as an autopsy finding in a patient who had died of a ruptured ectopic pregnancy and had an intrauterine pregnancy.1 Rarely an intrauterine twin gestation can co-exist with a heterotopic pregnancy or vice versa. Higher order heterotopic gestations are extremely rare.
Keywords: Heterotopic pregnancy; Life-threatening; Risk factors; Life-saving; Maternal col- lapse and death; Emergency laparotomy; Catastrophic hemorrhage; Maternal demise; Laparotomy
Heterotopic gestation defines the co-existence of both intrauterine gestation and an 1,2 ectopic gestation commonly in the fallopian tube and uncommonly in the cervix or ovary.1,2 The incidence is estimated to be 1:30,000 in spontaneous pregnancies.3 Pelvic inflammatory disease is believed to one of the aetiological factors associated with ectopic gestations. It can also occur 3 1 in patients without any risk factors.3 Heterotopic gestation can follow natural conception1 or assisted reproductive techniques like ovulation induction.4 It can occur up to 10-15% of all ectopic gestations following in vitro fertilisation.
A 27-year-old, para 1 gravida 2, was referred to me by a casualty officer. She was complaining of intermittent lower abdominal pains on and off for 2 weeks. She had done a pregnancy test and it was positive. She said that she was about 5 weeks pregnant. The pain worsened of late and she was now complaining of dizziness too. She was married and worked as a temporary primary school teacher. She had no significant past medical, surgical or gynecological º history. Initial examination revealed a pulse of 51 b/min, BP 101/50, and a temperature 34 ºC. She was pale and with a very tense and tender lower abdomen. The cervical os was closed with slight
any ultrasonography on her. I remarked that she was bleeding internally from a suspected tubal
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At laparoyomy, a 1.5 litres of hematoperitoneum was found with on-going hemorrhage from the fimbrial end of the left fallopian tube which had an ectopic gestational sac imbedded in it. A left salpingectomy was done and the abdomen was cleaned with saline. The specimen was sent for histological examination.
Post-operatively the patient remained stable and did not need any blood transfusion. She recovered promptly and requested to go home on day 2 post-operatively. Hematinics and antibiotics were prescribed for her. She was instructed to rest at home and to come for review in a week’s time.
At review her histology results were now available and had confirmed a tubal ectopic gestation. Her wound was healing well and her next review was at6 weeks post-operatively when we planned to discuss contraception and folic acid supplementation during her next pregnancy.
When she came at her 6 weeks review, she asked why her pregnancy test remained positive and her periods had not returned. I sent her for an ultrasound scan which revealed a viable intrauterine pregnancy of 15 weeks gestation. The diagnosis of heterotopic pregnancy was explained to her and she understood.
Her pregnancy progressed well and she delivered vaginally at term a baby girl weighing 3000 g.
The diagnosis of heterotopic pregnancy is a very difficult one to make. Like all ectopic gestations, delay in the diagnosis may lead to catastrophic hemorrhage and maternal demise including the intrauterine fetus. The management of heterotopic pregnancy is the gold standard laparoscopy or Laparotomy.5 In cases where there is a combination of an intrauterine pregnancy demonstrated by ulstrasonography and severe abdominal pains, clinicians should consider diagnostic laparoscopy without uterine instrumentation or laparotomy. This case needed no further delay as her health was at risk. During Laparotomy, she was indeed found to be hemorrhaging. If she had been sent for further tests she could have collapsed or needed blood transfusions. The survival rate of the intrauterine pregnancy with a favourable outcome is 50-60% of cases.6
Clinicians must remain vigilant in prompt management of suspected ectopic gestations, at times using clinical findings to institute life-saving surgery without waiting for tests as happened in this case. This is especially pertinent in resourcelimited environments. Making a retrospective diagnosis in a live patient is better than making it during a post-mortem examination.
The author declares no competing interests exists.
http://dx.doi.org/10.17140/GOROJ-2-117