Gynecology and Obstetrics Research · Vol. 3, No. 2 · 2016 · pp. e1–e4 · e-ISSN 2377-1542

Developmental Environmental Exposure Alters the Epigenetic Features of Myometrial Stem Cells

Qiwei Yang, Ayman Al-Hendy

Division of Translation Research, Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta University, Augusta, GA, USAUnited States

DOI: https://doi.org/10.17140/goroj-3-e005 · Published 2016-12-01 · Licence: https://creativecommons.org/licenses/by/4.0 · © 2016 The Author(s)

Also available as PDF (figures and tables appear in the PDF).

Abstract

Uterine fibroids (UFs), are the most common pelvic tumors, occurring in 70-80% of all reproductive-aged women and are the leading indication for hysterectomy worldwide.1-3 Although UFs are benign tumors, they typically cause severe menstrual bleeding, pelvic pain, preterm labor, recurrent abortion, and infertility. Hysterectomy is currently the main treatment used in women who no longer desire childbearing.

Acknowledgements

This work was supported in part by an Augusta University Startup package, the National Institutes of Health grant HD04622811 (to AA), and the Augusta University Intramural Grants Program (QY).

Conflicts Of Interest

None of the authors have a financial relationship with a commercial entity that has an interest in the subject of this manuscript.

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