Gynecology and Obstetrics Research · Vol. 8, No. 1 · 2022 · pp. 19–20 · e-ISSN 2377-1542

Induced Pluripotent Stem Cells—Derived Stem Cells: A Promising Tool for Disease Modeling

Parveen Parasar

Department of Neurology, Henry Ford Hospital, Detroit 48202, MI, USAUnited States

DOI: https://doi.org/10.17140/goroj-8-158 · Published 2022-11-28 · Licence: https://creativecommons.org/licenses/by/4.0 · © 2022 The Author(s)

Also available as PDF (figures and tables appear in the PDF).

Abstract

Stem cells possess potential to undergo self-renewability giving rise to any cell type in the body known as pluripotency. This process, also known as differentiation, through which stem cells undergo several morphologic and genetic changes resulting in daughter cell lineages. The end point lineage depends on the growth and differentiation induction factors or proteins added to in vitro stem cell culture.

Conclusion

gram somatic cells into iPSC with a remarkable pluripotency potential same as ESCs, but also paved a path to generate iPSCs from Due to lack of direct translatable animal models, it is needed that subjects with diseases carrying gene mutations in order to model a an in vitro cellular model derived from patient-derived iPSCs be credisease.

ated which provides a platform and cellular system to investigate pathogenetic mechanisms of diseases. Currently, various diseases iPSCs are innovative tools to study molecular mechanisms due to nature of their rare occurrence and/or fatal outcomes, reunderlying a disease. Thus, iPSCs provide a robust cellular system sult in lack of patient tissue samples and specimen and subjects to to study disease-specific phenotypes. Specifically, iPSCs provide an characterize diseases. For example, in neurological rare metabolic immensely useful system to investigate pathogenetic mechanisms disease, X-ALD, there is no genotype phenotype correction and of diseases for which there is no absolute animal model such as due to inaccessibility of tissue samples, research presents caveats 4 5 neuronal diseases,4 mitochondrial diseases, and metabolic diseases,5 in discovery of biomarkers. The development of patient-derived and lens-disorders.6 iPSC-derived normal and disease-specific tisstem cell model enables us to discover novel biomarkers of dissues or cells, owing to their pluripotency, enable us to establish a eases and design and screen therapies.

high-throughput screening system to strategize and identify therapies for diseases.

cc Copyright 2022 by Parasar P. This is an open-access article distributed under Creative Commons Attribution 4.0 International License (CC BY 4.0), which Gynecol Obstet Res Open J. 2022 8(1): 19-20. doi: 10.17140/GOROJ-8-158

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