Pregnancy-Induced Hypertension: Hyperuricemia as a Predictor of Perinatal Outcomes

Abstract

Aim/Objective
The aim of this study to determine the relationship between hyperuricemia and perinatal outcome in pregnancy induced hypertension.
Material & Methods
This prospective and observational study was carried out in the Department of Obstetrics & Gynecology of Tanta University. The study included (100) primigravida female patients in the third trimester (after 32 weeks gestation) with pregnancy induced hypertension .Serum uric acid assay was done then the patients were classified into three groups according to uric acid level; Group I (low hyperuricemia) uric acid below 25th percentile (<3.7 mg/dl ), group II (middle hyperuricemia) uric acid from 25th to 75th percentile (3.8 to 5.7 mg/dl ) and group III (high hyperuricemia) uric acid above 75th percentile (>5.8 mg/dl).
Follow up of maternal outcome as (eclampsia, HELLP, acute renal failure and accidental hemorrhage) and fetal outcomes (stillbirth, prematurity, IUGR and IUFD).
Other obstetric complication that can affect pregnancy, other medical disease and severe pre-eclampsia that need urgent termination were excluded.
Result
The results showed statistically significant increase of serum uric acid, urea and creatinine in high group compared to middle and low ones. Bad fetal outcome and pregnancy complications were directly proportionate to the serum uric acid level.
Conclusion
These data reinforce the general agreement about the utility of hyperuricemia in the prognosis of adverse perinatal outcomes in pregnancy induced hypertension. Serum uric acid level measurements are a useful and inexpensive marker for predicting adverse perinatal outcomes.