Inter-Relationship between Creatinine Phosphokinase and Ejection Fraction

Abstract

It is interesting to examine the associations between serum creatinine phosphokinase (CPK) level and some of the cardiac risk
factors such as blood pressure, heart rate, ejection fraction (EFT), etc. in heart patients. The article aims to examine the interrelationship
between CPK level and EFT in heart patients.
Methods
The inter-relationship between CPK level and EFT in heart patients is examined herein using the probabilistic model of CPK on
EFT along with the other explanatory variables and factors, and conversely. The CPK level or EFT model is derived by applying
joint generalized linear models (JGLMs).
Results
The CPK level mean model shows that mean CPK is directly related to EFT (p=0.04) and AGE (p=0.03), while it is inversely
related to their joint interaction effect of AGE and EFT, i.e., AGE*EFT (p=0.01). The mean CPK is inversely related to serum
creatinine (SCT) (p<0.01), while it is directly related to the EFT (p=0.04), and their joint interaction effect is EFT*SCT (p<0.01).
From the EFT mean model, it is derived that EFT is directly related to CPK (p=0.01) and AGE (p<0.01), while it is inversely
partially related to their joint interaction effect, AGE*CPK (p=0.12). Mean EFT is indifferent to SCT (p=0.39), while it is directly
related to the joint interaction effect of CPK (p=0.01) and SCT, i.e., CPK*SCT (p<0.01). Mean EFT is directly related to serum
sodium (SNa) (p<0.01) and CPK (p=0.01), while it is inversely related to the joint interaction effect of CPK*SNa (p=0.01). From
the variance model of EFT, the variance of EFT is inversely related to CPK (p=0.04).
Conclusion
Based on the derived CPK level and EFT models, it is derived that CPK and EFT are interrelated with each other through AGE,
SCT, SNa, and some interaction effects. Heart patients and practitioners should care about the interrelationship of CPK levels
and EFT for better treatment.