Oral and Gut Health Can Play an Important Role in Psychosomatic Illness Associated with Coronavirus Disease 2019 Patients

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Authors

  • Ravish Huchegowda, MBBS, MD Department of Neurochemistry, NIMHANS, Bangalore, India
  • Manoj K. Sharma, PhD Department of Clinical Psychology, NIMHANS, Bangalore, India
  • Nithin Anand, PhD Department of Clinical Psychology, NIMHANS, Bangalore, India
  • Darshana Devadiga, MDS Department of Conservative Dentistry and Endodontics, A.B.Shetty Memorial Institute of Dental Sciences, Mangaluru 575018, Karnataka, India

DOI:

https://doi.org/10.17140/NOJ-8-135

Keywords:

COVID-19; SARS-CoV-2; Dental; Stress; HPA

Abstract

With physicians and patients fearful of coronavirus disease 2019 (COVID-19), this has a profound impact on the working and
personal life and living style of individuals. In United States (U.S.), around 10.7% reported perceiving severe thoughts of hurting
themselves and contemplating suicide as a reaction. There is a 3-4 times rise in the incidence of mental well-being disorders in
the past year relative to the year prior as reported in the article in US. It was also confirmed that salivary glands of throats had
affected by coronavirus and many patients infected have developed dysgeusia and anosmia which are also happened to be found
in patients taking angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers, thus pointing out the role
of ACE receptors for entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Reducing technologic use and
addiction would be feasible by adequate sleep and preventing during work hours through reducing task triggering anxiety-related
use of mobile phones. Consuming plenty of Vitamin C can protect against such viral infections. Study have also shown that sufficient vitamin D supplementation could boost humoral and cellular immune responses and reduce intestinal leakiness among
COVID-19 infected population.

References

Czeisler MÉ, Lane RT, Petrosky E, Wiley JF, Christensen A, Njai R, Weaver MD, et al. Mental health, substance use, and suicidal ideation during the COVID-19 pandemic—United States, June 24- 30, 2020. MMWR Morb. Mortal. Wkly. Rep. 2020; 69: 1049-1057. doi: 10.15585/mmwr.mm6932a1

Simon NM, Saxe GN, Marmar CR. Mental health disorders related to COVID-19–related deaths. JAMA. 2020; 324(15): 1493- 1494. doi: 10.1001/jama.2020.19632

Fini MB. Oral saliva and COVID-19. Oral Oncol. 2020; 108: 104821. doi: 10.1016/j.oraloncology.2020.104821

Fuller C, Lehman E, Hicks S, Novick MB. Bedtime use of technology and associated sleep problems in children. Glob Pediatr Health. 2017; 4. doi: 10.1177/2333794X17736972

Hemilä H. Vitamin C and infections. Nutrients. 2017; 9: 339. doi: 10.3390/nu9040339

Name JJ, Souza ACR, Vasconcelos AR, Prado PS, Pereira CPM. Zinc, vitamin D and vitamin C. perspectives for COVID-19 with a focus on physical tissue barrier integrity. Front Nutr. 2020; 7: 606398. doi: 10.3389/fnut.2020.606398

Anderson G, Reiter RJ. COVID-19 pathophysiology: interactions of gut microbiome, melatonin, vitamin D, stress, kynurenine and the alpha 7 nicotinic receptor: Treatment implications. Melatonin Research. 2020; 3: 322-345. doi: 10.32794/mr11250066

Yan C, Luo Z, Li W, Li X, Dallmann R, Kurihara H, et al. Disturbed Yin-Yang balance: Stress increases the susceptibility to primary and recurrent infections of herpes simplex virus type 1. Acta Pharm Sin B. 2020; 10: 383-398. doi: 10.1016/j.apsb.2019.06.005

Zeiders KH. Discrimination, daily stress, sleep, and Mexican-origin adolescents’ internalizing symptoms. Cultur Divers Ethnic Minor Psychol. 2017; 23(4): 570-575. doi: 10.1037/cdp0000159

Vanuytsel T, van Wanrooy S, Vanheel H, Vanormelingen C, Verschueren S, Houben E, et al. Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism. Gut. 2014; 63: 1293- 1299. doi: 10.1136/gutjnl-2013-305690

Rajan ST, Priyanka HP. Bidirectional communication between the neuroendocrine system and the immune system: relevance to health and diseases. Ann Neurosci. 2012; 19: 40-46. doi: 10.5214/ ans.0972.7531.180410

Chen L, Li X, Chen M, Feng Y, Xiong C. The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2. Cardiovasc Res. 2020; Submit your article to this journal | https://openventio.org/submit-manuscript/ 4 Huchegowda R et al 116: 1097-1100. doi: 10.1093/cvr/cvaa078

Davidson AM, Wysocki J, Daniel B. Interaction of SARS-CoV-2 and other coronavirus with ACE (Angiotensin-Converting Enzyme)-2 as their main receptor. Hypertension. 2020; 76: 1339- 1349. doi: 10.1161/HYPERTENSIONAHA.120.15256

Li Y, Ren B, Peng X, Hu T, Li J, Gong T, et al. Saliva is a non-negligible factor in the spread of COVID-19. Mol Oral Microbiol. 2020; 35(4): 141-145. doi: 10.1111/omi.12289

Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X, et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci. 2020; 12. doi: 10.1038/s41368-020- 0074-x

Dziedzic A, Wojtyczka R. The impact of coronavirus infectious disease 19 (COVID-9) on oral health. Oral Dis. 2020; doi: 10.1111/ odi.13359

Anschau V, Sanjuán R. Fibrinogen gamma chain promotes aggregation of vesicular stomatitis virus in saliva. Viruses. 2020; 12(3): 282. doi: 10.3390/v12030282

Siqueira WL, Moffa EB, Mussi MCM, de Andrade Moreira Machado MA. Zika virus infection spread through saliva – a truth or myth? Braz Oral Res. 2016; 30: S1806-83242016000100801. doi: 10.1590/1807-3107BOR-2016.vol30.0046

Greer A, Zenobia C, Darveau RP. Defensins and LL-37: A review of function in the gingival epithelium. Periodontol. 2000; 63: 67-79. doi: 10.1111/prd.12028 Mini Review | Volume 8 | Issue 1 |

Published

2021-03-24

How to Cite

Ravish Huchegowda, MBBS, MD, Manoj K. Sharma, PhD, Nithin Anand, PhD, & Darshana Devadiga, MDS. (2021). Oral and Gut Health Can Play an Important Role in Psychosomatic Illness Associated with Coronavirus Disease 2019 Patients. Neuro, 8(1), 1–4. https://doi.org/10.17140/NOJ-8-135

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