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If history can serve as a guide quite some time can lapse between the inception of a concept and its proof. For instance, Einstein had described the special theory of relativity in 1905, but he published the general theory of relativity only after thinking about the problems for 10 years. On March 29, 1919, the opportunity to get proof came. British Astronomer Sir Arthur Eddington had traveled to Príncipe Island off the western coast of Africa. His team photographed star fields during the eclipse and compared the photos with those of the same star field taken when the sun was not present. Eddington found the apparent location of the stars had shifted, just as was predicted by Einstein’s theory. That 15-year delay between conception and proof did not cause suffering or deaths as was the case with the germ theory of Semmelweis, who did not live to see his momentous insight being accepted. He was declined reappointment and admitted to an asylum where he died after only two weeks with the following on his mind “When I look back upon the past, I can only dispel the sadness which falls upon me by gazing into that happy future when the infection will be banished . . . The conviction that such a time must inevitably sooner or later arrive will cheer my dying hour
Keywords: banished; gazing; inevitably
ISSN 2380-0445 http://dx.doi.org/10.17140/NPOJ-1-109 Open Journal Commentary Nephrology should Trail Blaze the End of * *Corresponding author Chronic Disease Rudolf Fluckiger, PhD Instructor Harvard Medical School Boston * Brigham and Women’s Hospital Rudolf Fluckiger, PhD* Orthopaedic Research (Retired) Novacule, LLC Instructor Harvard Medical School Boston, Brigham and Women’s Hospital, Orthopaedic Re- 2587 Albany Ave search (Retired), West Hartford, CT 06617, USA West Hartford, CT 06617, USA Tel. 860-519-1621 E-mail: Novacule@gmail.com Website: http://novacule.com/ If history can serve as a guide quite some time can lapse between the inception of a concept and its proof. For instance, Einstein had described the special theory of relativity in Volume 1 : Issue 3 1905, but he published the general theory of relativity only after thinking about the problems for 10 years. On March 29, 1919, the opportunity to get proof came. British Astronomer Sir Article Ref. #: 1000NPOJ1109 Arthur Eddington had traveled to Príncipe Island off the western coast of Africa. His team photographed star fields during the eclipse and compared the photos with those of the same star Article History th field taken when the sun was not present. Eddington found the apparent location of the stars had Received: February 4 , 2016 th shifted, just as was predicted by Einstein’s theory. That 15-year delay between conception and Accepted: February 25 , 2016 th proof did not cause suffering or deaths as was the case with the germ theory of Semmelweis, Published: February 25 , 2016 who did not live to see his momentous insight being accepted. He was declined reappointment and admitted to an asylum where he died after only two weeks with the following on his mind Citation “When I look back upon the past, I can only dispel the sadness which falls upon me by gazing Flückiger R. Nephrology should trail into that happy future when the infection will be banished . . . The conviction that such a time blaze the end of chronic disease.
must inevitably sooner or later arrive will cheer my dying hour”.
doi: 10.17140/NPOJ-1-109 The author postulates based on his personal experience and strive with cancer that the end of chronic disease is near. He postulates that chronic disease arrises whenever the innate immune system turns on the body. He feels that he cannot justify to wait until the editor of a prestigious medical journal decides to allow his manuscript to get peer reviewed until he let his unified theory of the cause of chronic disease become known. Too much is at stake, patients suffer unnecessarily and great cost is added to our overburdened health care system. So he 2 th takes the occasion of the Einstein’s anniversaries, 100 years relativity theory2 and his 60th death anniversary together with the generous invitation of Nephrology open journal editor Ms. K. Jessie to publish his theory. He bases his theory on four facts (1) he had managed to suppress the pain of his chemotherapy-induced peripheral neuropathic pain by attenuating the activity of the complement system with the mega dosed antioxidants Pyrroloquinoline quinone (PQQ) and N-acetylcysteine (NAC). They create a reactive oxygen radical-free state that prevents the activation of Transient Potential Receptor ion channels which serve as pain receptors; (2) that the metabolic syndrome of his wife resolved when taking PQQ/NAC; there is an obvious explanation for this reversal of diabetes. In the absence of attack by the complement system on the insulin producing beta cells they can recover and repopulate from resident stem cells to respond to physiological stimuli again. We hypothesize that similar mechanisms may be at work in other chronic disease states like Multiple Sclerosis, Alzheimer’s disease, Parkinson’s, Macular Degeneration, and Amyotrophic Lateral Sclerosis; (3) that the severity and frequency of migraine attacks decreased with PQQ/NAC intake; (4) that the pathophysiology underlying diabetes and migraine both involve Transient Receptor Potential (TRP) ion channels. It appears that the use of PQQ/NAC in Nephrology will most quickly yield the results to support our Copyright hypothesis as a dysfunctional immune system has been shown to be involved in causing renal ©2016 Flückiger R. This is an open damage.3 Based on this insight the highly potent complement inhibitor compstatin was de- access article distributed under the 4 signed. However, the toxicity of this compound does not allow it to be administered to patients Creative Commons Attribution 4.0 for prolonged periods of time. In contrast, PQQ/NAC are well tolerated, the author has used International License (CC BY 4.0), which permits unrestricted use, them to suppress his pain from peripheral neuropathy for over three years without experiencing distribution, and reproduction in any adverse side effects. According to the literature TRP ion channels have beneficial effects in any medium, provided the original some thirty medical conditions for many of which there currently exist no efficient therapies. work is properly cited.
Preventative long-term intake of PQQ/NAC is therefore a good way to swart off chronic dis- ISSN 2380-0445 http://dx.doi.org/10.17140/NPOJ-1-109 Open Journal ease and correct non-life threatening medical inconveniences.