Obesity Research · Vol. 2, No. 3 · 2015 · pp. e12–e14 · e-ISSN 2377-8385

Obesity Induced Inflammation – A Complex Condition

Elham Alipoor, Mohammad Javad Hosseinzadeh-Attar

DOI: https://doi.org/10.17140/oroj-2-e005 · Published 2015-11-18 · Licence: https://creativecommons.org/licenses/by/4.0 · © 2015 The Author(s)

Also available as PDF (figures and tables appear in the PDF).

Abstract

The occurrence of overweight and obesity has risen around the world. This rate will increase in the future without appropriate interventions. Obesity is a condition with increased percentage of fat mass. Evidence based studies indicate that excess adiposity is accompanied with a proinflammatory state. This low grade chronic inflammation could initiate and progress the metabolic disorders such as insulin resistance, type 2 diabetes, endothelial dysfunction, atherosclerosis and several types of cancers.1 There are outstanding differences between obesity induced inflammation and classic inflammation. Classic inflammation originates from the intense immune system response to an insult, results in Basal Metabolic Rate (BMR) increase and usually diminishes over time. In contrast, obesity induced inflammation is chronic, metabolic, moderate, and is associated with a reduced BMR. Some studies suggested the term “metaflammation” for this inflammatory condition

Keywords: inflammation; metaflammation

Acknowledgment

The authors appreciate Tehran University of Medical Sciences for their full support.

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