Obesity Research · Vol. 2, No. 1 · 2015 · pp. 39–41 · e-ISSN 2377-8385

Can Hormones Regulating Appetite be a Major Factor Contributing to Obesity?

Hala Mourad Demerdash

Assistant Professor of Clinical Pathology, Pharos University Al Shri Al Omomi, Qism Sidi Gabir Hala Mourad Demerdash Alexandria Governorate, EgyptEgypt

DOI: https://doi.org/10.17140/oroj-2-107 · Published 2015-04-13 · Licence: https://creativecommons.org/licenses/by/4.0 · © 2015 The Author(s)

Also available as PDF (figures and tables appear in the PDF).

Abstract

Obesity is a growing problem throughout the whole world; it is a complex condition that causes much suffering. There are many factors associated with obesity. Those factors include; individual genetics, increased food intake, and/or a lack of physical exercise. In addition hormonal balance plays a very critical role in weight control. There are a number of established hormonal disorders that is associated with obesity. The most common syndromes include Cushing’s syndrome and Hypothyroidism

Keywords: Gastrointestinal; ghrelin; Hypothyroidism

Conclusion

anabolic hormone in the bone.

The etiology of obesity is complex and multifactorial,

Insulin

one of the important factors is the regulation of food intake; there are a number of gastrointestinal hormones, which act additively It is a peptide hormone that is secreted from the beta in inducing satiety and achieving efficient nutrient absorption. cells of the pancreas. Insulin concentration in plasma increases rapidly after eating and decreases with starvation.

This coupled with incomplete understanding of all factors responsible of appetite regulation and prevention of obe- Plasma insulin levels are most sensitive to changes in sity. GIT hormones act through a short term effect; peptides as blood glucose concentrations. Insulin binds to its receptor to ini- GLP-1 decrease hypothalamic AMPK activity leading to reductiate GLUT-4 in order to allow glucose to enter the cell either tion in food intake, while ghrelin leads to AMPK activation and for energy production or storage. In addition, Plasma insulin increased food intake. On the other hand, long term effect proconcentrations depend on peripheral insulin sensitivity, which duced through peripheral adipose tissue hormones as leptin and is related to both total body fat stores and fat distribution, with adiponectin.

visceral fat being a key determinant.

This means that single treatment approach, may be in-

Peripheral Regulators Of Appetite- Adipose Tissue

efficient to control weight loss and may explain the failure of

Hormones

some morbidly obese patients to achieve a successful weight loss.

Adiponectin

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