Obesity Induced Inflammation – A Complex Condition
DOI:
https://doi.org/10.17140/OROJ-2-e005Keywords:
inflammation, metaflammationAbstract
The occurrence of overweight and obesity has risen around the world. This rate will
increase in the future without appropriate interventions. Obesity is a condition with increased
percentage of fat mass. Evidence based studies indicate that excess adiposity is accompanied
with a proinflammatory state. This low grade chronic inflammation could initiate and progress the metabolic disorders such as insulin resistance, type 2 diabetes, endothelial dysfunction, atherosclerosis and several types of cancers.1
There are outstanding differences between
obesity induced inflammation and classic inflammation. Classic inflammation originates from
the intense immune system response to an insult, results in Basal Metabolic Rate (BMR) increase and usually diminishes over time. In contrast, obesity induced inflammation is chronic,
metabolic, moderate, and is associated with a reduced BMR. Some studies suggested the term
“metaflammation” for this inflammatory condition
References
Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006; 444(7121): 860-867.
Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol. 2011; 29: 415-445.
Lago F, Dieguez C, Gomez-Reino J, Gualillo O. Adipokines as emerging mediators of immune response and inflammation. Na-ture clinica practice Rheumatology. 2007; 3(12): 716-724. doi: 10.1038/ncprheum0674
Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nature reviews Immunology. 2011; 11(2): 85-97. doi: 10.1038/nri2921
Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr. 2004; 92(3): 347-355. doi: 10.1079/BJN20041213
Trayhurn P, Wood IS. Signalling role of adipose tissue: adipokines and inflammation in obesity. Biochem Soc Trans. 2005; 33(Pt 5): 1078-1081. doi: 10.1042/BST0331078
Wang C. Obesity, inflammation, and lung injury (OILI): the good. Mediators Inflamm. 2014; 2014: 978463. doi: 10.1155/2014/ 978463
Ohashi K, Shibata R, Murohara T, Ouchi N. Role of anti-inflammatory adipokines in obesity-related diseases. Trends in endocri-nology and metabolism: TEM. 2014; 25(7): 348-355. doi: 10.1016/j.tem.2014.03.009
Ye J, McGuinness OP. Inflammation during obesity is not all bad: evidence from animal and human studies. American journalof physiology Endocrinology and metabolism. 2013; 304(5): E466-E477. doi: 10.1152/ajpendo.00266.2012
Ye J. Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes. Frontiers of medi-cine. 2015; 9(2): 139-145. doi: 10.1007/s11684-015-0377-z
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