Obesity Induced Inflammation – A Complex Condition

Abstract

The occurrence of overweight and obesity has risen around the world. This rate will
increase in the future without appropriate interventions. Obesity is a condition with increased
percentage of fat mass. Evidence based studies indicate that excess adiposity is accompanied
with a proinflammatory state. This low grade chronic inflammation could initiate and progress the metabolic disorders such as insulin resistance, type 2 diabetes, endothelial dysfunction, atherosclerosis and several types of cancers.1
There are outstanding differences between
obesity induced inflammation and classic inflammation. Classic inflammation originates from
the intense immune system response to an insult, results in Basal Metabolic Rate (BMR) increase and usually diminishes over time. In contrast, obesity induced inflammation is chronic,
metabolic, moderate, and is associated with a reduced BMR. Some studies suggested the term
“metaflammation” for this inflammatory condition