Inflammation Driven Activation of Wnt Pathway: A Potential Mechanism Responsible for Obesity-associated Colorectal Cancer

Abstract

Substantial evidence indicates that obesity, which has reached an epidemic proportion, is a robust risk factor for several types of cancer, particularly the colorectal cancer. As
the worldwide obesity epidemic has shown no sign to decrease, whereas further increases in
the scope of this problem are still projected, insight into the mechanisms of obesity-associated
tumorignesis is urgently needed for the development of preventive approaches to block this
process. Obesity is associated with multiple metabolic changes, and therefore a single mechanism is unlikely to be responsible for all obesity-associated tumors. A quite number of articles
provided systemic reviews of the possible mechanisms for the association between obesity and
the initiation and progression of cancers. In this mini-review, we focus on how obesity mediates
colorectal cancer via inflammation driven Wnt-signaling pathway