Pathology and Laboratory Medicine
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Histopathologic Patterns and Cytohistologic Correlation of Thyroid Lesions among Patients with Thyroid Biopsies in Jimma Medical Centre, South West Ethiopia: A Retrospective Study

Tewodros Wubshet, Tewodros Deneke, Eshetu Alemayehu

The question

What are the histopathologic patterns and cytohistologic correlation of thyroid lesions among patients with thyroid biopsy?

  • Fine needle aspiration cytology (FNAC) is an important initial screening tool and histopathologic examination is the gold standard in the definitive diagnosis of thyroid disease.

What was done

581biopsies reviewed
286FNAC cases reviewed
5 yearsstudy duration
  • A five-year retrospective study was conducted with a review of 581 biopsies submitted from thyroidectomy specimens at Jimma University Medical Centre (JUMC), Pathology Department from September 2015 to September 2020.
  • This also includes a review of 286 cases in which fine needle aspiration was done prior to surgery.
  • Data was analysed using Statistical Package for the Social Sciences (SPSS) version 26.

Key findings

Finding 1 of 4
71.8%
colloid goitre cases

Colloid goitre was found in 417 (71.8%) cases, while adenoma, carcinoma, and thyroiditis accounted for 54 (9.3%), 95 (16.3%) and 12 (2.1%) cases respectively.

Histopathology categories (% of biopsies)
  • Colloid goitre71.8%
  • Carcinoma16.3%
  • Adenoma9.3%
  • Thyroiditis2.1%
Finding 2 of 4
72.6%
papillary thyroid carcinoma among carcinomas

Papillary thyroid carcinoma was the most common subtype of carcinoma, accounting for 69 (72.6%) of the total 95 malignant cases.

Finding 3 of 4
86.6%
cyto-histologic correlation

Among 286 FNAC results, cyto-histologic correlation was achieved in 233 (86.6%) cases.

Finding 4 of 4
71%
FNAC sensitivity (specificity 92.7%)

Sensitivity and specificity of FNAC were 71% and 92.7% respectively, with diagnostic accuracy of 86.6%.

Why it matters

  • Nodular colloid goitre is by far the most common thyroid lesion and papillary thyroid carcinoma (PTC) is the most frequent histologic type of malignancy.
  • FNAC remains a sensitive, specific and accurate tool in the evaluation and management of thyroid lesions.

How to cite

Tewodros Wubshet, Tewodros Deneke, Eshetu Alemayehu. Histopathologic Patterns and Cytohistologic Correlation of Thyroid Lesions among Patients with Thyroid Biopsies in Jimma Medical Centre, South West Ethiopia: A Retrospective Study. Pathology and Laboratory Medicine. 2022;4(1):6-13. https://doi.org/10.17140/plmoj-4-112

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