Pulmonary Research and Respiratory Medicine · Vol. 2, No. 2 · 2015 · pp. 81–83 · e-ISSN 2377-1658

Hydrogen Sulfide in Airway Diseases

Pengyu Zhang, Xin Zhou, Feng Li

DOI: https://doi.org/10.17140/prrmoj-2-113 · Published 2015-05-26 · Licence: https://creativecommons.org/licenses/by/4.0 · © 2015 The Author(s)

Also available as PDF (figures and tables appear in the PDF).

Abstract

Hydrogen Sulfide (H2S) is a colorless, water-soluble gas with the odor of rotten eggs. H2S can be produced via non-enzymatic pathways, but is mainly synthesized from L-cysteine as the substrate by Cystathionine-γ-lyase (CSE), Cystathionine-β-synthetase (CBS) and 3-mer-captopyruvate sulfur transferase (3MTS).1 H2S is now recognized as the third signaling gas-otransmitter after Carbon monoxide (CO) and Nitric Oxide (NO), and it plays an important role in the pathophysiology of airway disease, such as asthma and Chronic Obstructive Pulmonary Disease (COPD).

Acknowledgement

This work was supported by grants No. 81100024 from the National Natural Science Foundation of China and No. 2011274 from the Shanghai Health Bureau.

References

  1. HatziefthimiouAStamatiouR. Role of hydrogen sulphide in airways. World J Respirol. 2015; In press
  2. WangPZhangGWondimuTRossBWangR. Hydrogen sulfide and asthma. Exp Physiol. 2011; 96: 847-852
  3. ZhangJWangXChenYYaoW. Correlation between levels of exhaled hydrogen sulfide and airway inflammatory phenotype in patients with chronic persistent asthma. Respirology. 2014; 19: 1165-1169. doi: 10.1111/resp.1237210.1111/resp.12372 https://doi.org/10.1111/resp.12372
  4. TianMWangYLuYQ. Correlation between serum H2S and pulmonary function in children with bronchial asthma. Mol Med Rep. 2012; 6: 335-338. doi: 10.3892/mmr.2012.90410.3892/mmr.2012.904 https://doi.org/10.3892/mmr.2012.904
  5. ChungKF. Hydrogen sulfide as a potential biomarker of asthma. Expert review of respiratory medicine. 2014; 8: 5-13. doi: 10.1586/17476348.2014.85626710.1586/17476348.2014.856267 https://doi.org/10.1586/17476348.2014.856267
  6. ChenYHWuRGengB. Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma. Cytokine. 2009; 45: 117-123. doi: 10.1016/j. cyto.2008.11.00910.1016/j.cyto.2008.11.009 https://doi.org/10.1016/j.cyto.2008.11.009
  7. ZhangGWangPYangG. The inhibitory role of hydrogen sulfide in airway hyperresponsiveness and inflammation in a mouse model of asthma. Am J Pathol. 2013; 182: 1188-1195. doi: 10.1016/j.ajpath.2012.12.00810.1016/j.ajpath.2012.12.008 https://doi.org/10.1016/j.ajpath.2012.12.008
  8. ChenYHYaoWZGengB. Endogenous hydrogen sulfide in patients with COPD. Chest. 2005; 128: 3205-3211. doi: 10.1378/chest.128.5.320510.1378/chest.128.5.3205 https://doi.org/10.1378/chest.128.5.3205
  9. SaitoJMackayAJRossiosC. Sputum-to-serum hydrogen sulfide ratio in COPD. Thorax. 2014; 69: 903-909. doi: 10.1136/thoraxjnl-2013-20486810.1136/thoraxjnl-2013-204868 https://doi.org/10.1136/thoraxjnl-2013-204868
  10. HanWDongZDimitropoulouC. Hydrogen sulfide ameliorates tobacco smoke-induced oxidative stress and emphysema in mice. Antioxid Redox Signal. 2011; 15: 2121-2134. doi: 10.1089/ars.2010.382110.1089/ars.2010.3821 https://doi.org/10.1089/ars.2010.3821
  11. ChenYHWangPPWangXM. Involvement of endogenous hydrogen sulfide in cigarette smoke-induced changes in airway responsiveness and inflammation of rat lung. Cytokine. 2011; 53: 334-341. doi: 10.1016/j.cyto.2010.12.00610.1016/j.cyto.2010.12.006 https://doi.org/10.1016/j.cyto.2010.12.006