Marked Enlargement of Liver Over a Short Period of Time

Ichiro Hirukawa, Takeshi Saraya, Shoko Wada, Hajime Takizawa

Department of Respiratory Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka City, Tokyo 181-8611, Japan KEYWORDS: Tumor lysis syndrome; Small cell lung cancer; Metastatic liver tumor; Liver enlargement; Short time period.

DOI: https://doi.org/10.17140/prrmoj-3-123 · Published 2016-02-22 · Licence: https://creativecommons.org/licenses/by/4.0 · © 2016 The Author(s)

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Keywords: Tumor lysis syndrome; Small cell lung cancer; Metastatic liver tumor; Liver enlargement; Short time period

PULMONARY RESEARCH AND RESPIRATORY MEDICINE ISSN 2377-1658 http://dx.doi.org/10.17140/PRRMOJ-3-123 Open Journal Illustration Marked Enlargement of Liver Over a Short * *Corresponding author Period of Time Takeshi Saraya, MD, PhD Assistant Professor Department of Respiratory Medicine Kyorin University School of Medicine * 6-20-2 Shinkawa, Mitaka City Ichiro Hirukawa, MD; Takeshi Saraya, MD, PhD ; Shoko Wada, MD; Hajime Takizawa, Tokyo 181-8611, Japan MD, PhD Tel. +81 (0)422 44 0671 Fax: +81 (0)422 44 0671 E-mail: sara@yd5.so-net.ne.jp Department of Respiratory Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka City, Tokyo 181-8611, Japan Volume 3 : Issue 1 Article Ref. #: 1000PRRMOJ3123 KEYWORDS: Tumor lysis syndrome; Small cell lung cancer; Metastatic liver tumor; Liver enlargement; Short time period.

Article History th Received: February 17th, 2016 nd ABSTRACT Accepted: February 22 , 2016 nd Published: February 22nd, 2016 An 81-year-old man with Small cell lung cancer (limited type), who had been treated with various intravenous chemotherapies combined with irradiation during the previous year, Citation was admitted to our hospital (day 1) for his third intravenous chemotherapy dose. Contrast- Hirukawa I, Saraya T, Wada S, Takiza- enhanced thoraco-abdominal computed tomography on day 1 demonstrated that the primary wa H. Marked Enlargement of Liver lung cancer had not grown (data not shown); however, multiple new metastatic tumors in the over a Short Period of Time. Pulm Res Respir Med Open J. 2016; 3(1): 1. liver, up to 5 mm in diameter, were seen (Figure A). Two weeks later, the liver was markedly doi: 10.17140/PRRMOJ-3-123 enlarged (Figure B) and repeated Computed tomography (CT). It demonstrated rapidly progressing; various sized multiple ring-enhanced tumors along with evidence of tumor lysis syndrome. On day 23, he died of multiple organ failure. Liver metastasis is a common occurrence in lung cancer patients, but the rapid enlargement of the liver over such a short time period is an extremely rare phenomenon.1

References

1. 1. Sato K, Takeyama Y, Tanaka T, Fukui Y, Gonda H, Suzuki R. Fulminant hepatic failure and hepatomegaly caused by diffuse liver metastases from small cell lung carcinoma: 2 autopsy cases. Respir Investig. 2013; 51(2): 98-102. doi: 10.1016/j.resinv.2012.12.004 Copyright ©2016 Saraya T. This is an open access article distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited https://doi.org/10.1016/j.resinv.2012.12.004