Hydrogen Sulfide in Airway Diseases
DOI:
https://doi.org/10.17140/PRRMOJ-2-113Abstract
Hydrogen Sulfide (H2S) is a colorless, water-soluble gas with the odor of rotten eggs. H2S can be produced via non-enzymatic pathways, but is mainly synthesized from L-cysteine as the substrate by Cystathionine-γ-lyase (CSE), Cystathionine-β-synthetase (CBS) and 3-mer-captopyruvate sulfur transferase (3MTS).1 H2S is now recognized as the third signaling gas-otransmitter after Carbon monoxide (CO) and Nitric Oxide (NO), and it plays an important role in the pathophysiology of airway disease, such as asthma and Chronic Obstructive Pulmonary Disease (COPD).
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