Hazard Assessments of Cattle Fascioliasis With Special Reference to Hemato-Biochemical Biomarkers
DOI:
https://doi.org/10.17140/VMOJ-2-111Keywords:
Hemoglobin; Leukocytes; Liver enzymes; Albumin; Creatinine.Abstract
Aim: Fascioliasis is a well known veterinary trouble in cattle and is to date an important human
being disease. The aim of this study was to evaluate the functional capacity of the liver based
on the activity of specific enzymes, proteins and glucose in serum and also to investigate the
influence of mechanical and toxic effects of fascioliasis on blood picture and biliary tract of
cattles.
Materials and Methods: This study was carried out between January and April 2016. Blood and
fecal samples were collected from 22 cattles with naturally acquired bovine fascioliasis and
no other disease out of 150 cattles and 10 non-infected cattles were brought to the Veterinary
Clinic, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt. Blood was
drawn from all the examined animals to measure the respective levels of hematological and
biochemical parameters.
Results: Investigation of the animals infected with fascioliasis showed paleness of mucous
membranes, loss in weight, watery diarrhea, visible submandibular edema and normal rectal
temperatures. Normocytic normochromic anemia with a significant decrease (p<0.05) in red
blood cells count (RBCs), hemoglobin (Hb) concentration, percentage of packed cell volume
(PCV %) were observed in an infected cattle compared to the uninfected control. In addition,
leukocytosis, neutrophilia, eosinophilia, lymphopenia and monocytopenia were reported.
Moreover, significant changes in the biochemical parameters were recorded.
Conclusion: From this study, it could be concluded that the determination of hematological and
biochemical parameters are useful in early diagnosis and prognosis of cattle fascioliasis.
References
Valeroa MA, Barguesa MD, Khoubbanea M, et al. Higher physiopathogenicity by Fasciola gigantica than by the genetically close F. hepatica: experimental long-term follow-up of biochemical markers. Trans R Soc Trop Med Hyg. 2016; 110(1): 55-66. doi: 10.1093/trstmh/trv110
Egbu FMI, Ubachukwu PO, Okoye IC. Haematological changes due to bovine fascioliasis. J Biotechnol. 2013; 12(15): 1828-1835. Web site. http://www.ajol.info/index.php/ajb/ article/view/128928. Accessed December 4, 2016.
Hassan K, Mohsen A, Mahmood MO, Mahdi D, Hossein H, Mohammarreza A. Prevalence of ruminants fascioliasis and their economic effects in Kashan, center of Iran. Asian Pac J Trop Biomed. 2014; 4(11): 918-922. doi: 10.12980/ APJTB.4.2014APJTB-2014-0157
Betül T, Ikbal O-B, Hasan T, Bahattin T. Severe iron deficiency anemia and marked eosinophilia in adolescent girls with the diagnosis of human fascioliasis. Turk J Pediatr. 2014; 56(3): 307- 309. Web site. http://search.proquest.com/openview/225f99d4a 575af4093f51f67a88abfe6/1?pq-origsite=gscholar&cbl=35236. Accessed December 4, 2016.
Mas-Coma S, Bargues MD, Esteban JG. Human Fascioliasis, In: Dalton JP. Fascioliasis. Wallingford, Oxon, United Kingdom; CAB Internatioal Publishers; 1999: 411-429.
Boone L, Meyer D, Cusick P, et al. Selection and interpretation of clinical pathology indicators of hepatic injury in preclinical studies. Vet Clin Pathol. 2005; 34(3): 182-188. doi: 10.1111/j.1939-165X.2005.tb00041.x
Teleb DF, Soliman EK, Abd EL- Khalek TMM. Effect of Fascioliasis on hematological, serum biochemical and histopathological changes in sheep. Egyptian J Sheep Goat Sci. 2007; 2(2): 15-34. Web site. https://www.cabdirect.org/ cabdirect/abstract/20113231953. Accessed December 4, 2016.
Okoye IC, Egbu FMI, Ubachukwu PO, Okafor FC. Biochemical alterations due to Bovine Fascioliasis. Intern J Sc Res. 2013; 2(11): 503-507.
Predescu G, Cozma V. Blood haematological and biochemical changes before and after treatment with Tolzan in bovine with chronic infestation with Fasciola spp. Sc Parasit. 2009; 10(1-2): 59-62. Web site. http://www.zooparaz. net/scientia/2009_10_01/2009_01_059-062.pdf. Accessed December 4, 2016.
Matanović K, Severin K, Martinković F, Šimpraga M, Janicki Z, Barišić J. Hematological and biochemical changes in organically farmed sheep naturally infected with Fasciola hepatica. J Parasitological Res. 2007; 101(6): 1463-1731. doi: 10.1007/s00436-007-0709-2
Urquhart GM, Armour J, Duncan JL, Dunn AM, Jennings FW. Veterinary Parasitology, 2nd ed. Blackwell Science, London; Wiley; 1996: 110-307.
Talukder S, Bhuiyan MJ, Hossain MM, Uddin MM, Paul S, Howlader MMR. Pathological investigation of liver fluke infection of slaughtered Black Bengal Goat in a selected area of Bangladesh. Bangladesh J Vet Med. 2010; 8(1): 35-40. doi: 10.3329/bjvm.v8i1.7717
Olu OS, Salami O, samaila D, Isreal O, Lusharkiah A. Clinical, gross and histopathological changes associated with chronic fasciolosis infection in a dairy farm. J Vet Adv. 2012; 2(8): 444-448. Web site. http://www.scopemed. org/?jft=74&ft=74-1338995779. Accessed December 4, 2016.
Torgerson P, Claxton J. “Epidemiology and Control” In Dalton, JP. Fasciolosis. Wallingford, Oxon, UK; CABI Publisher; 1999: 113-149.
Dalton JP. Fasciolosis. Reproductive Technologies in Farm Animals. Dublin City University, Ireland; CABI Publishing; 2004: 191-201.
Lotfollahzadeh S, Mohri M, Bahadori SR, Dezfouly MR, Tajik P. The relationship between normocytic, hypochromic anaemia and iron concentration together with hepatic enzyme activities in cattle infected with Fasciola hepatica. J Helminthol. 2008; 82(1): 85-88. doi: 10.1017/S0022149X07874232
Kaneko JJ, Harvey JW, Bruss ML. Clinical Biochemistry of Domestic Animals. 5th ed. New York, USA; Academic Press; 1997.
Kramer JW. Schalm’s Veterinary Haematology. 5th ed. New York, USA; Wiley; 2000.
Lotfy HS, Mahmoud SM, Abdel-Gawad MA. Some studies on Fascioliasis in Mid-Egypt. Agric Res. 2003; 81(2): 209-227.
Molina EC, Lozano SP, Barraca AP. The relationship between haematological indices, serum gamma-glutamyl transferase and glutamate dehydrogenase, visual hepatic damage and worm burden in cattle infected with Fasciola gigantica. J Helminthol. 2006; 80(3): 277-279. doi: 10.1079/JOH2006337
Haroun EM, Hussein MF. Clinico-pathological studies on naturally-occurring bovine fascioliasis in the Sudan.J Helminthol. 1975; 49(3): 143-152. doi: 10.1017/S0022149X00023567
Waweru JG, Kanyari PWN, Mwangi DM, Ngatia TA, Nansen P. Comparative parasitological and haematological changes in two breeds of sheep infected with Fasciola gigantica. Trop Anim Health Prod. 1999; 31(6): 363-372. doi: 10.1023/A:1005221108013
El-Aziz MZA, Emara SA, Salem FS. Clinico-pathological studies on fascioliasis among sheep in Giza province. Egyptian J Vet Sci. 2002; 36: 75-86.
Ahmed MI, Ambali AG, Baba SS. Hematological and biochemical responses of Balami sheep to experimental Fasciola gigantica infection. J Food Agric Environ. 2006; 4(2): 71-74.
Rowlands D, Clampitt RB. Plasma enzyme levels in ruminants infected with Fasciola hepatica. Vet Parasitol. 1979; 5(2-3): 155-175. doi: 10.1016/0304-4017(79)90007-4
Penny JW, Scott, PR, LowJC, Honeyman PC. Bovine Fascioliasis in Nigeria. Tropical Animal Health and Production. 1996; 14(2): 121-124.
Widjajanti S, Estuningsih SE, Partoutomo S, et al. The responses of eosinophil and packed cell volume (PCV) in sheep infected with Fasciola gigantica. J Ilmu Ternak dan Veteriner. 2002; 7(3): 200-206.
Radostits OM, Gay CC, Blood DC, Hinchcliff KW. Veterinary Medicine. 9th ed. W.B. Saunders Company Ltd, London, USA; 2007.
Vengust G, Klinkon M, Bidovec A, Vengust A. Fasciola hepatica: effects on blood constituents and liver minerals in fallow deer (Dama dama). Vet Parasitol. 2003; 112(1-2): 51-61. doi: 10.1016/S0304-4017(02)00413-2
Hodžić A, Zuko A, Avdić R, Alić A, Omeragić J, Jažić A. Influence of Fasciola hepatica on Serum Biochemical Parameters and Vascular and Biliary System of Sheep Liver. Iranian J Parasitol. 2013; 8(1): 92-98. Web site. http://ijpa.tums. ac.ir/index.php/ijpa/article/view/520/0. Accessed December 4, 2016.
Sayed AS, Abd El-Salam MN, Elissa NA, Abd El-Ghafar SK. Clinical laboratory studies on Fascioliasis in cattle and buffaloes. Beni-Suef Vet Med Res. 1998; 2: 151- 179.
Gajewska A, Smaga-Kozłowska K, Wiśniewski M. Pathological changes of liver in infection of Fasciola hepatica. Wiad Parazytol. 2005; 51(2): 115-123. Web site. http:// europepmc.org/abstract/med/16838620. Accessed December 4, 2016.
Amer SA, Osman SA, Harfoush MA. Epizootical and serological studies on fascioliasis in cattle. Zag Vet J. 2002; 30(1): 107-116.
Duncan JR, Prasse KW, Mahaffey EA. Veterinary Laboratory Medicine. 3rd ed. Ames, IA, USA: Iowa State University Press; 1994.
Soulsby EJL. Helminths, Arthropods and Protozoa of Domesticated Animals. 7th ed. Balliere Tindall, London, UK; Lea & Febiger Publisher; 1982.
SandraM,TietzM,MariaLSB,MariaIAE.Glomerulonephritis in water buffaloes (Bubalus bubalis) naturally infected by Fasciola hepatic. Vet Parasitol. 2004; 123(1-2): 83-91.
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