Report on a Case of Blighted Ovum

Crossmark: check for updates

Authors

  • Ryan R. Sanni, MD
  • Sandeep Mellacheruvu, MD, MPH
  • Frederick M. Tiesenga, MD
  • Aqsaa N. Chaudhry, MBA

DOI:

https://doi.org/10.17140/whoj.2024.v10.i01.pp03-04.9

Keywords:

deficiency anemia, urinary frequency

Abstract

Presenting in her late twenties, this case report examines a G6P2 patient at 11-weeks gestation that was diagnosed with a blighted
ovum, as well as the subsequent outcome and methods of additional management. A blighted ovum refers to a fertilized egg that
does not develop, despite the formation of a gestational sac. The most common cause of a blighted ovum is of genetic origin.
Trisomies account for most first trimester miscarriages, while consanguineous marriages result in recurrent miscarriages due to
a blighted ovum. Additionally, a higher percentage of deoxyribonucleic acid (DNA) damage in sperm carries a higher rate of
miscarriage. Nutritional factors that may lead to a blighted ovum include low-levels of copper, prostaglandin E2, and anti-oxidative
enzymes. High body mass index (BMI), especially in women with a BMI≥30 kg/m2
has been shown to be linked to a blighted
ovum. Globally, it has been shown that a blighted ovum is a serious adverse event related to vaccination against dengue fever

References

Barash JH, Buchanan EM, Hillson C. Diagnosis and manage-ment of ectopic pregnancy. Am Fam Physician. 2014; 90(1): 34-40.

PDQ Adult Treatment Editorial Board. Gestational Trophoblastic Disease Treatment (PDQ®): Health Professional Version. Bethesda, MD, USA: PDQ Cancer Information Summaries; 2019.

Chaudhry K, Siccardi MA. Blighted Ovum (Anembryonic Pregnancy). Bethesda, MD, USA: StatPearls Publishing LLC; 2019.

Henderson DJ, Bennett PR, Moore GE. Expression of hu-man chorionic gonadotrophin α and β subunits is depressed with early embryonic failure. Hum Reprod. 1992; 7(10): 1474-1478. doi: 10.1093/oxfordjournals.humrep.a137597

Al-Ma’ani W, Solomayer E-F, Hammadeh M. Expectant versus surgical management of first-trimester miscarriage: A randomized controlled study. Arch Gynecol Obstet. 2014; 289(5): 1011-1015. doi: 10.1007/s00404-013-3088-1

Downloads

Published

2024-02-24

How to Cite

Ryan R. Sanni, MD, Sandeep Mellacheruvu, MD, MPH, Frederick M. Tiesenga, MD, & Aqsaa N. Chaudhry, MBA. (2024). Report on a Case of Blighted Ovum. Women’s Health, 3–4. https://doi.org/10.17140/whoj.2024.v10.i01.pp03-04.9

Issue

Volume 10 Issue 1 2024

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

All content published in Women's Health (WH) is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license allows anyone to copy, distribute, transmit, and adapt the work — including for commercial purposes — provided appropriate credit is given to the original author(s) and source.

Most read articles by the same author(s)