Reduced Sampling Schedules for Calculation of an Insulin Sensitivity Index from the Liquid Meal Tolerance Test

Authors

  • Chad M. Cook Mary R. Dicklin and Kevin C. Maki Biofortis Clinical Research, 211 East Lake Street, Addison, IL 60101, USA
  • Tia M. Rains Mary R. Dicklin and Kevin C. Maki Biofortis Clinical Research, 211 East Lake Street, Addison, IL 60101, USA
  • Kathleen Kelley Mary R. Dicklin and Kevin C. Maki Biofortis Clinical Research, 211 East Lake Street, Addison, IL 60101, USA
  • Andrea Lawless Mary R. Dicklin and Kevin C. Maki Biofortis Clinical Research, 211 East Lake Street, Addison, IL 60101, USA
  • Arianne L. Schild Mary R. Dicklin and Kevin C. Maki Biofortis Clinical Research, 211 East Lake Street, Addison, IL 60101, USA

DOI:

https://doi.org/10.17140/DROJ-1-104

Keywords:

Type 2 diabetes mellitus, Insulin resistance, Insulin sensitivity, Glucose tolerence test

Abstract

Background: The objective of this study was to evaluate the performance of the Matsuda index of insulin sensitivity (MISI) calculated using reduced sampling schedules. Methods: Relationships between MISI values from a Liquid Meal Tolerance Test (LMTT) and
insulin sensitivity (SI) derived from an intravenous glucose tolerance test were assessed in 24 overweight/obese subjects (67% women) without diabetes. Results: Significant correlations were found between SI and 1) MISI calculated from 0, 30, 60, 90, and 120 min (r=0.776, p<0.0001); 2) MISI calculated from 0, 60, and 120 min (r=0.815, p<0.0001); and 3) MISI calculated from and 0 and 120 min (r=0.848, p<0.0001). Conclusion: MISI from LMTTs calculated using reduced sampling schedules (0, 60, 120 min or 0, 120 min) may be useful, lower cost options for assessment of insulin sensitivity in population studies and large clinical trials.

References

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Published

2015-03-25

How to Cite

Chad M. Cook, Tia M. Rains, Kathleen Kelley, Andrea Lawless, & Arianne L. Schild. (2015). Reduced Sampling Schedules for Calculation of an Insulin Sensitivity Index from the Liquid Meal Tolerance Test. Diabetes Research, 1(1), 24–26. https://doi.org/10.17140/DROJ-1-104

Issue

Vol. 1 No. 1 (2015): Volume 1 Issue 1 2015

Section

Articles

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