Effect of GlucoSEB™ Supplement on the Blood Glucose Level in Diabetic Patients: A Case Study
Keywords:
Diabetes; GlucoSEB™; Blood glucose level, Continuous glucose monitoring; Safety; Tolerance.Abstract
Diabetes is becoming a globally prevalent disease that puts a burden on healthcare systems and poses challenges to risk management.
Diabetes leads to microvascular and macrovascular complications. Therefore, maintaining normoglycemia is essential to improving
the quality of life and preventing morbidity and mortality in people with diabetes (PwD). A current study was performed
to check the effect of GlucoSEB™ supplement on the blood glucose level of Type 2 diabetes mellitus (T2DM) patients. Subjects
in this study were blinded to the treatment; they received a placebo for the initial seven days, followed by GlucoSEB™ for the next
seven days. Blood glucose was monitored with a continuous glucose monitoring (CGM) device. Administration of GlucoSEB™
caused a decrease in blood glucose level, glucose area under the curve (AUC), and an improvement in time in range (TIR). Also,
GlucoSEB™ was well tolerated by all the patients, indicating the safety of the supplement. Thus, GlucoSEB™ supplementation
positively influenced blood glucose parameters and helped curb blood glucose excursions.
References
Caturano A, D’Angelo M, Mormone A, et al. Oxidative stress in type 2 diabetes: Impacts from pathogenesis to lifestyle modifi-cations. Curr Issues Mol Biol. 2023; 45(8): 6651-6666. doi: 10.3390/ cimb45080420
Sun H, Saeedi P, Karuranga S, et al. IDF diabetes atlas: Glob-al, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022; 183: 109119. doi: 10.1016/j.diabres.2021.109119
Anjana RM, Unnikrishnan R, Deepa M, et al. Metabolic non-communicable disease health report of India: the ICMR-INDIAB national cross-sectional study (ICMR-INDIAB-17). Lancet Diabetes Endocrinol. 2023; 11: 474-489. doi: 10.1016/S2213- 8587(23)00119-5
Ong KL, Stafford LK, McLaughlin SA, et al. Global, regional, and national burden of diabetes from 1990 to 2021, with projec-tions of prevalence to 2050: A systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2023; 402: 203-234. doi: 10.1016/S0140-6736(23)01301-6
Schreck K, Melzig MF. Traditionally used plants in the treat-ment of diabetes mellitus: Screening for uptake inhibition of glu-cose and fructose in the caco2-cell model. Front. Pharmacol. 2021; 12: 692566. doi: 10.3389/fphar.2021.692566
Modak M, Dixit P, Londhe J, Ghaskadbi S, Devasagayam TP. Indian herbs and herbal drugs used for the treatment of diabetes. J Clin Biochem Nutr. 2007; 40(3): 163-173. doi: 10.3164/jcbn.40.163
Breton C, Snajdrová L, Jeanneau C, Koca J, Imberty A. Struc-tures and mechanisms of glycosyltransferases. Glycobiology. 2005; 16(2): 29-34. doi: 10.1093/glycob/cwj016 Submit your article to this journal | https://openventio.org/submit-manuscript/ Case Study | Volume 10 | Number 1 | Rathi A, et al
Taniguchi N, Honke K, Fukuda M. Handbook of GlycosylTrans-ferases and Related Genes. 2nd ed. Tokyo, Japan: Springer Publishers; 2002.
Majeed M, Majeed A, Nagabhusahnam K, Mundkar L, Paulose S. A randomized, double-blind clinical trial of a herbal formu-lation (GlycaCare-II) for the management of type 2 diabetes in comparison with metformin. Diabetol Metabol Syndr. 2021; 13(1): 132. doi: 10.1186/s13098-021-00746-0
Gheldof N, Francey C, Rytz A, et al. Effect of different nu-tritional supplements on glucose response of complete meals in two crossover studies. Nutrients. 2022; 14(13): 2674. doi: 10.3390/ nu14132674
Golovinskaia O, Wang C.K. The hypoglycemic poten-tial of phenolics from functional foods and their mechanisms. Food Sci Hum Wellness. 2023; 12(4): 986-1007. doi: 10.1016/j. fshw.2022.10.020
Plou FJ, Martín MT, deSegura AG, Alcade M, Ballesteros A. Glucosyltransferases acting on starch or sucrose for the synthe-sis of oligosaccharides. Can J Chem. 2002; 80(6): 743-752. doi: 10.1139/v02-104
Wei B, Wang L, Su L, et al. Structural characterization of slow digestion dextrin synthesized by a combination of α-glucosidase and cyclodextrin glucosyltransferase and its prebiotic potential on the gut microbiota in vitro. Food Chem. 2023; 426: 136554. doi: 10.1016/j.foodchem.2023.136554
Song JY, Kim YM, Lee BH, Yoo SH. Increasing the dietary fiber contents in isomaltooligosaccharides by dextransucrase re-action with sucrose as a glucosyl donor. Carbohydr Polym. 2020; 230: 115607. doi: 10.1016/j.carbpol.2019.115607
Sanz ML, Côté GL, Gibson GR, Rastall RA. Prebiotic proper-ties of Alternansucrase maltose-acceptor oligosaccharides. J Agric Food Chem. 2005; 53(15): 5911-5916. doi: 10.1021/jf050344e
Li Y, Ren J, Liu J, et al. Modification by α-D-glucan branching enzyme lowers the in vitro digestibility of starch from different sources. Int J Biol Macromol. 2018; 107: 1758-1764. doi: 10.1016/j. ijbiomac.2017.10.049
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
All content published in Diabetes Research (DR) is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license allows anyone to copy, distribute, transmit, and adapt the work — including for commercial purposes — provided appropriate credit is given to the original author(s) and source.
