Model Based vs. Rule Based Designs in Phase I Dose Finding Clinical Trials

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Authors

  • Yunfei Wang
  • Jichuan Wang

DOI:

https://doi.org/10.17140/CTPOJ-1-e001

Abstract

A phase I clinical trial is needed when a new drug or treatment is first used in human subjects. For ethnic reason, in such a trial, we have to carefully balance the possible benefit and harm so that the benefit is maximized and harm is minimized, which deems that the design is adaptive with small sample size, and is primarily focusing on safety end-points with efficacy end-points as secondary ones.

References

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Published

2016-06-07

How to Cite

Yunfei Wang, & Jichuan Wang. (2016). Model Based vs. Rule Based Designs in Phase I Dose Finding Clinical Trials. Clinical Trials and Practice – Open Journal, 1(1), e1-e2. https://doi.org/10.17140/CTPOJ-1-e001

Issue

Vol. 1 No. 1 (2017): Volume 1 Issue 1 2017

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

All content published in Clinical Trials and Practice – Open Journal (CTP) is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license allows anyone to copy, distribute, transmit, and adapt the work — including for commercial purposes — provided appropriate credit is given to the original author(s) and source.