Aquagenic Pruritus: First Manifestation of Polycythemia Vera

Abstract

Aquagenic Pruritus (AP) can be a first symptom of systemic disease; especially strong
correlation with myeloproliferative disorders was described. In Polycythemia Vera (PV) patients
its prevalence varies from 31% to 69%. In almost half of the cases AP precedes the
diagnosis of PV and has significant influence on sufferers’ quality of life. Due to the lack of
the insight in pathogenesis of AP the treatment is still largely experiential. However, the new
JAK1/2 inhibitors showed promising results in management of AP among PV patients.