Shaping Up Mitochondrion in Motion
DOI:
https://doi.org/10.17140/DRMTOJ-1-111Keywords:
Mitochondria, Morphology, Lymphocytes, Dermal papilla, Migration, OPA1Abstract
We previously reported that hair follicle dermal papilla cells (HFDPCs) show two types of
mitochondria, which are filamentous (untangled) and rounded (tangled) mitochondria. Plateletderived
growth factor-AA (PDGF-AA) shifts the population balance toward the filamentous
type that produces more adenosine triphosphate (ATP) than the other. In addition, the cells
show filamentous mitochondria during the process of cellular migration. Furthermore, here
we demonstrated that an inner membrane protein, optic atrophy 1 (OPA1), is involved in the
filamentous-rounded transition of the organelle. We suggest that OPA1 confers longitudinal
rigidity on the filamentous mitochondria. Other cells such as breast cancer cells utilize small
fragmented mitochondria, instead of a filamentous form, in the migration process. Regarding
the apparent inconsistency with those other reports on the morphological change upon the onset
of cellular migration, we discuss communal feature of the regulation of mitochondrial morphology
in different cellular systems: all previous reports showed that the organelle become slender
or smaller in the energy-demanding activity.
References
Patrushev MV, Mazunin IO, Vinogradova EN, Kamenski PA. Mitochondrial fission and fusion. Biochemistry (Mosc). 2015; 80(11): 1457-1464. doi: 10.1134/S0006297915110061
Mishra P, Chan DC. Metabolic regulation of mitochondrial dynamics. J Cell Biol. 2016; 212(4): 379-387. doi: 10.1083/ jcb.201511036
Wai T, Langer T. Mitochondrial dynamics and metabolic reg-ulation. Trends Endocrinol Metab. 2016; 27(2): 105-117. doi: 10.1016/j.tem.2015.12.001
Liesa M, Palacín M, Zorzano A. Mitochondrial dynamics in mammalian health and disease. Physiol Rev. 2009; 89(3): 799- 845. doi: 10.1152/physrev.00030.2008
Youle RJ, van der Bliek AM. Mitochondrial fission, fusion, and stress. Science. 2012; 337(6098): 1062-1065. doi: 10.1126/ science.1219855
Chen L, Winger AJ, Knowlton AA. Mitochondrial dynamic changes in health and genetic diseases. Mol Biol Rep. 2014; 41(11): 7053-7062. doi: 10.1007/s11033-014-3663-y
López-Lluch G, Irusta PM, Navas P, de Cabo R. Mitochon-drial biogenesis and healthy aging. Exp Gerontol. 2008; 43(9): 813-819. doi: 10.1016/j.exger.2008.06.014
Campello S, Scorrano L. Mitochondrial shape changes: Or-chestrating cell pathophysiology. EMBO Rep. 2010; 11(9): 678- 684. doi: 10.1038/embor.2010.115
Hudson L, Bowman A, Rashdan E, Birch-Machin MA. Mito-chondrial damage and ageing using skin as a model organ. Ma-turitas. 2016. doi: 10.1016/j.maturitas.2016.04.021 Dermatol Open J
Feichtinger RG, Sperl W, Bauer JW, Kofler B. Mitochondrial dysfunction: A neglected component of skin diseases. Exp Der-matol. 2014; 23(9): 607-614. doi: 10.1111/exd.12484
Kandola K, Bowman A, Birch-Machin MA. Oxidative stress a key emerging impact factor in health, ageing, lifestyle and aes-thetics. Int J Cosmet Sci. 2015; 37(Suppl 2): 1-8. doi: 10.1111/ ics.12287
Mifude C, Kaseda K. PDGF-AA-induced filamentous mito-chondria benefit dermal papilla cells in cellular migration. Int J Cosmet Sci. 2015; 37(3): 266-271. doi: 10.1111/ics.12190
da Silva AF, Mariotti FR, Máximo V, Campello S. Mitochon-dria dynamism of shape, transport and cell migration. Cell Mol Life Sci. 2014; 71(12): 2313-2324. doi: 10.1007/s00018-014- 1557-8
Zhao J, Zhang J, Yu M, et al. Mitochondrial dynamics regu-lates migration and invasion of breast cancer cells. Oncogene. 2013; 32(40): 4814-4824. doi: 10.1038/onc.2012.494
Campello S, Lacalle RA, Bettella M, Mañes S, Scorrano L, Viola A. Orchestration of lymphocyte chemotaxis by mito-chondrial dynamics. J Exp Med. 2006; 203(13): 2879-2886. doi: 10.1084/jem.20061877
van der Bliek AM, Shen Q, Kawajiri S. Mechanisms of mi-tochondrial fission and fusion. Cold Spring Harb Perspect Biol. 2013; 5(6): 1-16.
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