Spongiosis: A Short Review

Authors

  • Hanan Rabea Nada Department of Dermatology, Cairo University, Cairo, Egypt

DOI:

https://doi.org/10.17140/DRMTOJ-2-126

Keywords:

Spongiosis, Dermatitis, Fas

Abstract

Spongiosis is the hallmark of eczematous dermatitis. The mechanism underlying it is somewhat
complex and is not fully understood up till now. Many factors interplay to produce spongiosis.
One of these factors is Fas receptor/Fas ligand interaction.

References

Swindells K, Burnett N, Rius-Diaz F, González E, Mihm MC, González S. Reflectance confocal microscopy may dif-ferentiate acute allergic and irritant contact dermatitis in vivo. J Am Acad Dermatol. 2004; 50(2): 220-228. doi: 10.1016/j. jaad.2003.08.005

Astner S, Gonzalez E, Cheung AC, Rius-Diaz F, González S. Pilot study on the sensitivity and specificity of in-vivo reflec-tance confocal microscopy in the diagnosis of allergic contact dermatitis. J Am Acad Dermatol. 2005; 53(6): 986-992. doi: 10.1016/j.jaad.2005.08.026

Wolff K, Kibbi AG, Mihm MC. Basic pathologic reactions of the skin. In: Fitzpatrick TB, ed. Dermatology in General Medi-cine. New York, USA: McGraw-Hill; 1993: 66-84.

Machado-Pinto J, McCalmont TH, Golitz LE. Eosinophilic and neutrophilic spongiosis: Clues to the diagnosis of immuno-bullous diseases and other inflammatory disorders. Semin Cutan Med Surg. 1996; 15: 308-316.

Trautmann A, Akdis M, Bröcker EB, et al. New insights into the role of T cells in atopic dermatitis and allergic contact der-matitis. Trends Immunol. 2001; 22(10): 530-532. doi: 10.1016/ S1471-4906(01)02004-X

Graham J. Basic pathologic changes in the skin. In: Graham JH, Johnson WC, Helwig EB, eds. Dermal Pathology. Hager-stown, MD, USA: Harper & Row, Publishers, Inc.; 1972: 119- 135.

Stenn KS, Balin AK, Higgins T, et al. Spongiosis. J Am Acad Dermatol. 1981; 5(2): 213-214.

Ussing HH, Windhager EE. Nature of shunt path and active sodium transport path through frog skin epithelium. Exp Cell Res. 1964; 61: 484-450.

Voute CL, Ussing HA. Quantitative relation between hydro-static pressure gradient, extracellular volume and active sodium transport in the epithelium of the frog skin. Exp Cell Res. 1970; 62(2-3): 375383. doi: 10.1016/0014-4827(70)90568-9

Carasso N, Favard P, Jard S, Morel F. The isolated frog skin epithelium. I. Preparation and general structure in differ-ent physiological states. J Microscopic. 1977; 10: 315-330. doi: 10.1007/BF00588577

Amagai M. Adhesion molecules. I. Keratinocyte-keratino-cyte interactions; cadherins and pemphigus. J Invest Dermatol. 1995; 104: 146-152.

Koch AW, Bozic D, Pertz O, Engel J. Homophilic adhesion by cadherins. Curr Opin Struct Biol. 1999; 9: 275-281. doi: 10.1016/S0959-440X(99)80038-4

Hakimelahi S, Parker HR, Gilchrist AJ, et al. Plakoglobin regulates the expression of the anti-apoptotic protein BCL-2. J Biol Chem. 2000; 275(15): 10905-10911. doi: 10.1074/ jbc.275.15.10905

Angst BD, Marcozzi C, Magee AI. The cadherin superfam-ily: Diversity in form and function. J Cell Sci. 2001; 114: 629- 641.

Ivanov DB, Philippova MP, Tkachuk VA. Structure and func-tions of classical cadherins. Biochemistry (Mosc). 2001; 66(10): 1174-1186. doi: 10.1023/A:1012445316415

Takeichi M. Structure and functions of classical cadherins. Curr Opin Cell Biol. 1995; 7(5): 619-627. doi: 10.1016/0955- 0674(95)80102-2

Ozawa T, Ringwald M, Kemler R. Uvomorulin-catenin com-plex formation is regulated by a specific domain in the cytoplas-mic region of the cell adhesion molecule. Proc Natl Acad Sci U S A. 1990; 87: 4246-4250. doi: 10.1073/pnas.87.11.4246

Pokutta S, Herrenknecht K, Kemler R, Engel J. Conforma-tional changes of the recombinant extracellular domain of E-cadherin upon calcium binding. Eur J Biochem. 1994; 223(3): 1019-1026. doi: 10.1111/j.1432-1033.1994.tb19080.x

Haussinger D, Ahrens T, Sass HJ, Pertz O, Engel J, Grzesiek S. Calcium-dependent homoassociation of E-cadherin by NMR spectroscopy: Changes in mobility, conformation and mapping of contact regions. J Mol Biol. 2002; 324(4): 823-839. doi: 10.1016/S0022-2836(02)01137-3

Brieher WM, Yap AS, Gumbiner BM. Lateral dimerization is required for the homophilic binding activity of C-cadherin. J Cell Biol. 1996; 135(2): 487-496. doi: 10.1083/jcb.135.2.487

Fujimori T, Takeichi M. Disruption of epithelial cell-cell adhesion by exogenous expression of a mutated nonfunctional N-cadherin. Mol Biol Cell. 1993; 4(1): 37-47. doi: 10.1091/ mbc.4.1.37

Ozawa M, Baribault H, Kemler R. The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 1989; 8(6): 1711-1717.

Yamada S, Pokutta S, Drees F, Weis WI, Nelson WJ. De-constructing the cadherin-catenin-actin complex. Cell. 2005; 123(5): 889-901. doi: 10.1016/j.cell.2005.09.020

Yonemura S, Wada Y, Watanabe T, Nagafuchi A, Shibata M. Alpha-catenin as a tension transducer that induces adherens junction development. Nat Cell Biol. 2010; 12(6): 533-542. doi: 10.1038/ncb2055

Shibamoto S, Hayakawa M, Takeuchi K, et al. Structure and functions of classical cadherins. Cell Adhes Commun. 1994; 1(4): 295-305. doi: 10.3109/15419069409097261

Brabant G, Hoang-Vu C, Behrends J, et al. Regulation of the cell-cell adhesion protein, E-cadherin, in dog and human thyro-cytes in vitro. Endocrinology. 1995; 136: 3113-3119.

Williams SL, Hayes VY, Hummel AM, et al. Regulation of E-cadherin-mediated adhesion by muscarinic acetylcholine re-ceptors in small cell lung carcinoma. J Cell Biol. 1993; 121(3): 643-654. doi: 10.1083/jcb.121.3.643

Yap AS, Brieher WM, Gumbiner BM. Molecular and func-tional analysis of cadherin-based adherens junctions. Ann Rev Cell Dev Biol. 1997; 13: 119-146. doi: 10.1146/annurev.cell-bio.13.1.119

Vestweber D, Gossler A, Boller K, Kemler R. Expression and distribution of cell adhesion molecule uvomorulin in mouse preimplantation embryos. Dev Biol. 1987; 124: 451-456. doi: 10.1016/0012-1606(87)90498-2

Fanjul-Fernández M, Quesada V, Cabanillas R, et al. Cell-cell adhesion genes CTNNA2 and CTNNA3 are tumour sup-pressors frequently mutated in laryngeal carcinomas. Nat Com-mun. 2013; 4: 2531. doi: 10.1038/ncomms3531

Gambichler T, Othlinghaus N, Tomi NS, et al. Medium dose ultraviolet (UV) A1 vs. narrowband UVB phototherapy in atopic eczema: A randomized crossover study. Br J Dermatol. 2009; 160(3): 652-658. doi: 10.1111/j.1365-2133.2008.08984.x

Zeisberg M, Hanai J, Sugimoto H, et al. BMP-7 counteracts TGF-beta1-induced epithelialto- mesenchymal transition and re-verses chronic renal injury. Nat Med. 2003; 9(7): 964-968. doi: 10.1038/nm888

Maddaluno L, Rudini N, Cuttano R, et al. EndMT contrib-utes to the onset and progression of cerebral cavernous mal-formations. Nature. 2013; 498(7455): 492-496. doi: 10.1038/ nature12207

Payne AS, Hanakawa Y, Amagai M, et al. Desmosomes and disease: Pemphigus and bullous impetigo. Curr Opin Cell Biol. 2004; 16(5): 536-543. doi: 10.1016/j.ceb.2004.07.006

Awad MM, Calkins H, Judge DP. Mechanisms of disease: Molecular genetics of arrhythmogenic right ventricular dyspla-sia/ cardiomyopathy. Nat Clin Pract Cardiovasc Med. 5(5): 258- 267. doi: 10.1038/ncpcardio1182

El-Amraoui A, Petit C. Cadherin defects in inherited human diseases. In: van Roy F, ed. The Molecular Biology of Cadher-ins. Amsterdam, Netherlands: Elsevier; 2013: 361-384.

Natbony SF, Phillips ME, Godfrey HP, et al. Histologic stud-ies of chronic idiopathic urticaria. J Allergy ClinImmunol. 1983; 71(2): 177-183.

Hertle K, Mobacken H. Hyperkeratotic dermatitis of the palms. Br J Dermatol. 107: 195-201. doi: 10.1007/978-3-642- 02035-3_19

Kaur P, Li A. Adhesive properties of human basal epidermal cells: an analysis of keratinocyte stem cells, transit amplifying cells, and postmitotic differentiating cells. J Invest Dermatol. 2000; 114(3): 413-420. doi: 10.1046/j.1523-1747.2000.00884.x

Norris DA, Middleton MH, Whang K, et al. Human kerati-nocytes maintain reversible anti-apoptotic defenses in vivo and in vitro. Apoptosis. 1977; 2: 136-148.

Chitaev NA, Troyanovsky SM. Direct Ca2+-dependent het-erophilic interaction between desmosomalcadherins, desmo-glein and desmocollin, contributes to cell-cell adhesion. J Cell Biol. 1997; 138(1): 193-201.

Hanakawa Y, Amagai M, Shirikata Y, Sayama K, Hashimoto K. Different effects of dominant negative mutants of desmocol-lin and desmoglein on the cell-cell adhesion of keratinocytes. J Cell Sci. 2000; 113: 1803-1811.

Vallorosi CJ, Day KC, Zhao X, et al. Truncation of the bcatenin binding domain of E-cadherin precedes epithelial apop-tosis during prostate and mammary involution. J Biol Chem. 2000; 275: 3328-3334.

Schwarz T. No eczema without keratinocyte death. J Clin Invest. 2000; 106: 9-10. doi: 10.1074/jbc.275.5.3328

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Published

2017-08-14

How to Cite

Hanan Rabea Nada. (2017). Spongiosis: A Short Review. Dermatology, 2(2), 36–40. https://doi.org/10.17140/DRMTOJ-2-126

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Vol. 2 No. 2 (2017): Volume 2 Issue 2 2017

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