Skin Autofluorescence a Non-Invasive Biomarker of Advanced Glycation End-Products and Its Association to Metabolic Parameters in a Greek Diabetic Population

Abstract

This cross-sectional study aims to evaluate the association between advanced glycation end-products (AGEs) accumulation, assessed
by skin autofluorescence (SAF) measured using the AGE Reader, and the prevalence of several metabolic variables in a diabetic
population The measurement of SAF has become a non-invasive method of assessing the accumulation of AGEs as a marker of the long-term impact of glycemic and oxidative stress in humans. In contrast to blood glucose and to hemoglobin A1C (HbA1c), which reflect a short period of glucose levels, the AGE is a marker of the metabolic legacy effect and reflect a long period of glucose levels. AGEs play a pivotal role in the development and progression of diabetic complications. SAF has been validated as a simple, non-invasive method for assessment of AGEs accumulation in the body.