Percutaneous Endoscopic Gastrostomy: Use and Abuse in Clinical Practice
DOI:
https://doi.org/10.17140/GOJ-1-110Keywords:
Percutaneous Endoscopic Gastrostomy (PEG), Indications, Contraindications, Clinical practice, Ethical IssuesAbstract
Nowadays, Percutaneous Endoscopic Gastrostomy (PEG) is considered the method of choice for long-term enteral feeding, and is spreading all over the world because of its effectiveness and easy carrying out. This review encompasses indications and contraindications of PEG tube placement, and deals with the problem of the growing disconnect between scientific evidence and clinical practice. Despite the evidence shows an advantage in the outcome from PEG placement only in selected subgroups of patients, this technique is also used for questionable indications in clinical practice, such as advanced dementia, permanent vegetative state, and even in end-life patients. Such an overuse is indirectly confirmed by several studies reporting a high 30-day mortality rate after PEG placement in elderly patients. The decision of placing PEG in end-stage patients involves very complex ethical issues, and the authors of this review are not so pretentious as to think themselves capable of dealing with and solving such a dramatic issue. However, patients’ interests should be better protected by a case-by-case decision making, based not only on technical competence, but also on sympathetic awareness, avoiding to perform procedures that can be disadvantageous for the patients.
References
McWhirter JP, Penninglon CR. Incidence and recognition of malnutrition in hospital. BMJ. 1994; 308: 945-948. doi: 10.1136/ bmj.308.6934.945
Volkert D, Berner YN, Berry E, et al. ESPEN Guidelines on Enteral Nutrition: Geriatrics. Clin Nutr. 2006; 25: 330-360. doi: 10.1016/j.clnu.2006.01.012
National Institute for Health and Clinical Excellence. Nutri-tion support in adults: oral nutrition support, enteral tube feeding and parenteral nutrition, 2006. Available at: www.nice.org.uk/ cg32. Accessed May 2014.
Gauderer MWL, Ponsky JL, Izant RJ Jr. Gastrostomy with-out laparotomy: a percutaneous endoscopic technique. J Pediatr Surg. 1980; 15: 872-875.
Sacks BA, Vine HS, Palestrant AM, Ellison HP, Shropshire D, Lowe R. A nonoperative technique for establishment of a gas-trostomy in the dog. Invest Radiol. 1983; 18: 485-487.
Russell TR, Brotman M, Norris F. Percutaneous gastrostomy, a new simplified and cost-effective technique. Am J Surg. 1984; 148: 132-137. doi: 10.1016/0002-9610(84)90300-3
Wills JS, Oglesby JT. Percutaneous gastrostomy. Radiology. 1983; 149: 449-452.
Roche V. Percutaneous endoscopic gastrostomy: clinical care of PEG tubes in older adults. Geriatrics. 2003; 58: 22-29.
McClave SA, Ritchie CS. The role of endoscopically placed feeding or decompression tubes. Gastroenterol Clin North Am. 2006; 35: 83-100. doi: 10.1016/j.gtc.2005.12.003
Othman AA, Dutta S. Population pharmacokinetics of levodopa in subjects with advanced Parkinson’s disease: levodo-pa-carbidopa intestinale gel infusion vs. oral tablets. Br J Clin Pharmacol. 2014; 78: 94-105. doi: 10.1111/bcp.12324
Ramage JI Jr, Baron TH. Percutaneous endoscopic cecosto-my: a case series. Gastrointest Endosc. 2003; 57: 752-755. doi: 10.1067/mge.2003.197
Dhooge M, Gaudric M. Non-surgical access for enteral nutritional: gastrostomy and jejunostomy, technique and re-sults. J Visceral Surg. 2013; 150S: S19-S26. doi: 10.1016/j. jviscsurg.2013.05.003
Stewart JA, Hagan P. Failure to transilluminate the stomach is not an absolute contraindication to PEG insertion. Endoscopy. 1998; 30: 621-622. doi: 10.1055/s-2007-1001367
Schrag SP, Sharma R, Jaik NP, et al. Complications related to percutaneous endoscopic gastrostomy (PEG) tubes. A com-prehensive clinical review. J Gastrointest Liver Dis. 2007; 16: 407-418.
McClave SA, Neff RL. Care and long-term maintenance of percutaneous endoscopic gastrostomy tubes. JPEN. 2006; 30: S27-S38. doi: 10.1177/01486071060300S1S27
Norton B, Homer-Ward M, Donnelly MT, Long RG, Hol-mes GK. A randomised prospective comparison of percutane-ous endoscopic gastrostomy and nasogastric tube feeding after acute dysphagic stroke. BMJ. 1996; 312: 13-16. doi: 10.1136/ bmj.312.7022.13
Geeganage C, Beavan J, Ellender S, Bath PM. Interven-tions for dysphagia and nutritional support in acute and subacute stroke. Cochrane Database Syst Rev. 2012; 10: CDooo323. doi: 10.1002/14651858.CD000323.pub2
Mekhail TM, Adelstein DJ, Rybicki LA, Larto MA, Sax-ton JP, Lavertu P. Enteral nutrition during the treatment of head and neck carcinoma: is a percutaneous endoscopic gastrostomy tube preferable to a nasogastric tube? Cancer. 2001; 91: 1785- 1790. doi: 10.1002/1097-0142(20010501)91:9<1785::AID-CNCR1197>3.0.CO;2-1
Nugent B, Lewis S, O’Sullivan JM. Enteral feeding methods for nutritional management in patients with head and neck cancers being treated with radiotherapy and/or chemotherapy. Cochrane Database Syst Rev. 2010; 3: CD007904. doi: 10.1002/14651858. CD007904.pub3
Katzberg HD, Benatar M. Enteral tube feeding for amyo-trophic lateral sclerosis/motor neuron disease. Cochrane Da-tabase Syst Rev. 2011; 1: CD004030. doi: 10.1002/14651858. CD004030.pub3
Humbert IA, Robbins J. Dysphagia in the elderly. Phys Med Rehabil Clin N Am. 2008; 19: 853-866.
Kayser-Jones J, Pengilly K. Dysphagia among nursing home residents. Geriatr Nurs. 1999; 20: 77-84. doi: 10.1053/gn.1999. v20.97011
Mendiratta P, Tilford JM, Prodhan P, Curseen K, Azhar G, Wei JY. Trends in Percutaneous endoscopic gastrostomy place-ment in the elderly from 1993 to 2003. Am J Alzheimers Dis Other Demen. 2012; 27: 609-613. doi: 10.1177/1533317512460563
Teno JM, Mor V, De Silva D, Kabumoto G, Roy J, Wetle T. Use of feeding tubes in nursing home residents with severe cog-nitive impairment. JAMA. 2002; 287: 3211-3212. doi: 10.1001/ jama.287.24.3206
Gessert CE, Mosier MC, Brown EF, Frey B. Tube feeding in nursing home residents with severe and irreversible cognitive impairment. J Am Geriatr Soc. 2000; 48: 1593-1600.
Mitchell SL, Teno JM, Roy J, Kabumoto G, Mor V. Clini-cal and organizational factors associated with feeding tube use among nursing home residents with advanced cognitive impair-ment. JAMA. 2003; 290: 73-80. doi: 10.1001/jama.290.1.41
Teno JM, Mitchell SL, Gozalo PL, et al. Hospital character-istics associated with feeding tube placement in nursing home residents with advanced cognitive impairment. JAMA. 2010; 303: 544-550. doi: 10.1001/jama.2010.79
Wirth R, Bauer JM, Willschrei HP, Volkert D, Sieber CC. Prevalence of percutaneous endoscopic gastrostomy in nursing home residents. A nationwide survey in Germany. Gerontology. 2010; 56: 371-377. doi: 10.1159/000265998
Johnston SD, Tham TC, Mason M. Death after PEG: results of a National Confidential Enquiry into patient outcome and death. Gastrointest Endosc. 2008; 68: 223-227. doi: 10.1016/j. gie.2007.10.019
Sampson EL, Candy B, Jones L. Enteral tube feeding for older people with advanced dementia. Cochrane Database Syst Rev. 2009; 2: CD007209. doi: 10.1002/14651858.CD007209. pub2
Malmgren A, Hede GW, Karlstrom B, et al. Indications for percutaneous endoscopic gastrostomy and survival in old adults. Food Nutr Res. 2011; 55. doi: 10.3402/fnr.v55i0.6037
Franceschi M, Busellato V, Borriero B, et al. Short and long-term mortality after percutaneous endoscopic gastrostomy. Ab-str XVII National Congress of Digestive Disease. Dig Liv Dis. 2011; 43(S3): S260.
Lesi C, Fabozzi M, Valeriani L, Zoni L. Artificial nutrition and aspects of bioethics: medical therapy or basic care? Italian J Medicine. 2010; 4: 63-69.
Ganzini L. Artificial nutrition and hydration at the end of life: ethics and evidence. Palliat Support Care. 2006; 4: 135-143.
Clarfield AM, Monette J, Bergman H, et al. Enteral feeding in end-stage dementia: a comparison of religious, ethnic and na-tional differences in Canada and Israel. J Gerontol A Biol Med Sci. 2006; 61: 621-627.
Geppert CM, Andrews MR, Druyan ME. Ethical issues in artificial nutrition and hydration: A Review. JPEN. 2010; 34: 79- 88. doi: 10.1177/0148607109347209
McNamara EP, Kennedy NP. Tube feeding patients with ad-vanced dementia: an ethical dilemma. Proc Nutr Soc. 2001; 60: 179-185. doi: 10.1079/PNS200083
Gauderer M. Twenty years of percutaneous endoscopic gas-trostomy: origin and evolution of a concept and its expanded applications. Gastrointest Endosc. 1999; 50: 879-883. doi: 10.1016/S0016-5107(99)70186-0
Brody H, Hermer LD, Scott LD, Grumbles LL, Kutac JE, McCammon SD. Artificial nutrition and hydration: the evolu-tion of ethics, evidence, and policy. J Gen Intern Med. 2011; 26: 1053-1058. doi: 10.1007/s11606-011-1659-z
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