Brunner Gland Cyst: Two Cases of a Rare Entity and Review of the Literature
DOI:
https://doi.org/10.17140/GOJ-1-113Keywords:
Duodenum, Brunner gland, Cystadenoma, Cyst, HamartomaAbstract
Objective: Brunner gland cysts are rare with only 14 cases reported in the literature. The term has been used to consolidate the following entities: Brunner’s gland cyst, cystic Brunner’s gland hamartoma, Brunner’s gland cystadenoma and mucocele of the Brunner gland.
Methods: We present the clinico-pathological features of two cases of Brunner gland cyst along with a review of the literature.
Results: Brunner gland cyst affects slightly more men than women. The age range is 30 to 72 years with an average of 55 years. The lesions range from 1 to 5 cm in size, the average being 2.3 cm in greatest dimension. The majority of lesions are found incidentally in patients with symptoms not specifically related to the lesion. They affect predominantly the first and second portion of duodenum. The majority of the lesions are single and pedunculated filling the sub mucosa. They can be unilocular or contain multiple cysts divided by fineseptae. The epithelial lining is of columnar and clear cells with basally located nuclei.
Conclusion: Brunner gland cysts are benign lesions that are usually not diagnosed pre-operatively. The cases described here add awareness of this entity among pathologists and gastro enterologists allowing for a better recognition of this rare entity.
References
Rankin FW, Newell CE. Benign tumors of the small intestine. Surg Gynec Obstet. 1933; 57: 501-507.
Varnholt H, Gang DL, Desilets DJ, et al. Brunner gland cyst. Int J Surg Pathol. 2007; 15: 64-65.
Powers M, Sayuk GS, Wang HL. Brunner gland cyst: report of three cases. Int J Clin Exp Pathol. 2008; 1: 536-538.
Galiatsatos P. A case of mistaken lipoma. Diagnosis: Brun-ner gland cyst. Gastroenterology. 2011; 141 (4): 1159-1160. doi: 10.1053/j.gastro.2010.07.054
Park BJ, Kim MJ, Lee JH, et al. Cystic Brunner’s gland hama-rtoma in the duodenum: A case report. World J Gastroenterol. 2009; 15: 4980-4983. doi: 10.3748/wjg.15.4980
Yamakawa M, Murata I, Yamao T, et al. Cystic Brunner’s gland hamartoma. Gastrointest Endosc. 2003; 57: 919.
Chatelain D, Maillet E, Boyer L, et al. Brunner gland hama-rtoma with predominant adipose tissue and ciliated cysts. Arch Pathol Lab Med. 2002; 126: 734-735.
Fisher JK. Mucocele of a Brunner gland. Radiology. 1980; 136: 320. doi: 10.1148/radiology.136.2.7403503
Golan J, Dollberg L, Dollberg M, et al. Cystic hamartoma of Brunner’s glands. Int Surg. 1978; 63: 173-175.
Taura M, Taura S, Kummerow FA, et al. An ultrastructural study of the Brunner’s cyst. Gastroenterol Jpn. 1977; 12: 241- 244. doi: 10.1007/BF02781769
Wolk DP, Knapper WH, Farr GH. Brunner’s gland cystade-noma of the duodenum. Am J Surg. 1973; 126: 439-440. doi: 10.1016/S0002-9610(73)80141-2
Hately W. Cyst of Brunner’s glands. Br J Radiol. 1968; 41: 384-385.
Katzin WE, Petras RE. Small Intestine. In: Mills SE, ed. Histology for pathologists, 4th edn. Philadelphia, PA: Lippincott Williams & Wilkins; 2012: 657-659.
Levine JA, Burgart LJ, Batts KP, et al. Brunner’s gland hamartomas: clinical presentation and pathological features of 27 cases. Am J Gastroenterol. 1995; 90: 290-294.
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