Overriding Elements in Colon Cancer Progression: Some Less Known Facts

Abstract

Colorectal cancer (CRC) is one of the most life threatening disease with escalating mortality and morbidity. Some known causative factors include lifestyle, alcohol etc. but there are other aspects like long standing colitis, inhibition of apoptotic proteins, chemokines and their receptors and inflammasomes which increase the chances of CRC progression. In a clinical setting of diseases like colitis and Crohn’s disease, the risk of CRC varies on degree of inflammation, expression of chemokines and cytokines and other molecular alterations. Hence, the underlying molecular inductions determine the fate of CRC progression through extent of epithelial mesenchymal transition, metastasis and invasive ability. The present view point will showcase some of the latent and notable considerations in CRC progression.