CD4:CD8 Ratio and Non-AIDS Defining Events in Virally Suppressed HIV Infected Patients: Need to Look Beyond CD4+ T-Cell Counts

Abstract

Antiretroviral therapy has led to improvement in life-expectancy through viral suppression and improved immune status. This brings in the concern about the non-AIDS defining illnesses which are mostly age associated such as cardiovascular disease, stroke, renal disease, liver disease, neurocognitive disorders, and non-AIDS malignancies. These are reported to be present at comparatively younger ages in HIV-infected patients.