Determination on the Expression of Activated RANTES G 28 in HIV-1 Infection and in Co Infection with Hepatitis B Virus and Hepatitis C Virus and Its Effect on Leukocytes

Abstract

Human Immunodeficiency Virus (HIV), coinfected with hepatitis B virus and hepatitis C virus challenges the immune system. Regulated on activation normal T cell expressed and secreted (RANTES) is one of the natural ligands for the chemokine, uses receptor which potently suppresses viral infection. We examined possible activation of RANTES G 28 in HIV 1 infection and in coinfection with HBV and HCV and its effect on leukocytes. Leukocytes from HIV-1infected HIV-1/HBV and HCV/HIV co-infected individuals were assessed by flow cytometry and Abacus 5 automated. RANTES G 28 was determined by Polymerase Chain Reaction. RANTES G 28 demonstrated positive correlation with HIV-1, HIV/HBV, HIV-1/HCV coinfection and leukocytes. The association presented difference in coefficient and predication of its occurrence. High expression of RANTES G 28 was indicated with stated the leukocytes. Difference in significance was indicated. There is need of more research to study and under stand the functions of RANTES G 28 with reference to human system and its role in immunity.