Determination on the Expression of Activated RANTES G 28 in HIV-1 Infection and in Co Infection with Hepatitis B Virus and Hepatitis C Virus and Its Effect on Leukocytes

Authors

  • Catherine M. Tsuma Jomo Kenyatta University of Agriculture and Technology, Institute of Biotechnology Research, Nairobi, Kenya
  • Rebecca Waihenya Jomo Kenyatta University of Agriculture and Technology, Institute of Biotechnology Research, Nairobi, Kenya
  • Matilu Mwau Jomo Kenyatta University of Agriculture and Technology, Institute of Biotechnology Research, Nairobi, Kenya

DOI:

https://doi.org/10.17140/HARTOJ-2-110

Keywords:

HIV-1 infection, HIV-1/HBV coinfection, HIV-1/HCV coinfection, Leukocytes, Rantes G 28

Abstract

Human Immunodeficiency Virus (HIV), coinfected with hepatitis B virus and hepatitis C virus challenges the immune system. Regulated on activation normal T cell expressed and secreted (RANTES) is one of the natural ligands for the chemokine, uses receptor which potently suppresses viral infection. We examined possible activation of RANTES G 28 in HIV 1 infection and in coinfection with HBV and HCV and its effect on leukocytes. Leukocytes from HIV-1infected HIV-1/HBV and HCV/HIV co-infected individuals were assessed by flow cytometry and Abacus 5 automated. RANTES G 28 was determined by Polymerase Chain Reaction. RANTES G 28 demonstrated positive correlation with HIV-1, HIV/HBV, HIV-1/HCV coinfection and leukocytes. The association presented difference in coefficient and predication of its occurrence. High expression of RANTES G 28 was indicated with stated the leukocytes. Difference in significance was indicated. There is need of more research to study and under stand the functions of RANTES G 28 with reference to human system and its role in immunity.

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Published

2015-06-26

How to Cite

Catherine M. Tsuma, Rebecca Waihenya, & Matilu Mwau. (2015). Determination on the Expression of Activated RANTES G 28 in HIV-1 Infection and in Co Infection with Hepatitis B Virus and Hepatitis C Virus and Its Effect on Leukocytes. HIV/AIDS/Research/and/Treatment, 2(2), 65–71. https://doi.org/10.17140/HARTOJ-2-110

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Vol. 2 No. 2 (2015): Volume 2 Issue 2 2015

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