Successful Treatment of Autoimmune Hemolytic Anemia Concurrent With Gastric Cancer by Rituximab: A Case Report of Evans Syndrome

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Authors

  • Hitoshi Hanamoto Department of Hematology, Nara Hospital, Kindai University Faculty of Medicine, 1248-1 Otoda-chou, Ikoma City, Nara 630-0293, Japan
  • Keigo Sano Department of Hematology, Nara Hospital, Kindai University Faculty of Medicine, 1248-1 Otoda-chou, Ikoma City, Nara 630-0293, Japan
  • Ryousuke Fujiwara Department of Hematology, Nara Hospital, Kindai University Faculty of Medicine, 1248-1 Otoda-chou, Ikoma City, Nara 630-0293, Japan
  • Aki Fuji Department of Hematology, Nara Hospital, Kindai University Faculty of Medicine, 1248-1 Otoda-chou, Ikoma City, Nara 630-0293, Japan
  • Mariko Fujita Department of Hematology, Nara Hospital, Kindai University Faculty of Medicine, 1248-1 Otoda-chou, Ikoma City, Nara 630-0293, Japan
  • Keiko Yamazaki Department of Hematology, Nara Hospital, Kindai University Faculty of Medicine, 1248-1 Otoda-chou, Ikoma City, Nara 630-0293, Japan
  • Hideo Yagi Department of Hematology, Nara Hospital, Kindai University Faculty of Medicine, 1248-1 Otoda-chou, Ikoma City, Nara 630-0293, Japan
  • Kazuo Tsubaki Department of Hematology, Nara Hospital, Kindai University Faculty of Medicine, 1248-1 Otoda-chou, Ikoma City, Nara 630-0293, Japan

DOI:

https://doi.org/10.17140/IMOJ-1-101

Keywords:

Evans syndrome, Autoimmune hemolytic anemia, Thrombocytopenia, Rituximab, Gastric cancer

Abstract

The concurrence of autoimmune hemolytic anemia (AIHA), thrombocytopenic purpura (Evans syndrome) and solid cancer is rare. In this study, we report a diabetic patient with gastric cancer who developed AIHA and idiopathic thrombocytopenic purpura. Steroid therapy for Evans syndrome restored platelet count; however, no improvement in AIHA was observed. Rituximab administration as a second-line therapy resulted in gradual improvement of anemia.  Our observation suggested rituximab as an effective therapy for steroid-resistant AIHA.

References

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Published

2016-09-14

How to Cite

Hitoshi Hanamoto, Keigo Sano, Ryousuke Fujiwara, Aki Fuji, Mariko Fujita, Keiko Yamazaki, … Kazuo Tsubaki. (2016). Successful Treatment of Autoimmune Hemolytic Anemia Concurrent With Gastric Cancer by Rituximab: A Case Report of Evans Syndrome. Internal Medicine, 1(1), 1–5. https://doi.org/10.17140/IMOJ-1-101

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