Rare Case of Metastatic Cholangiocarcinoma leading to Panhypopituitarism

Crossmark: check for updates

Authors

  • Emilia Surzyn West Virginia University (WVU),Wheeling Hospital,Wheeling,WV 26003, USA
  • Sathyanarayana Machani West Virginia University (WVU),Wheeling Hospital,Wheeling,WV 26003, USA

DOI:

https://doi.org/10.17140/IMOJ-7-122

Keywords:

Cholangiocarcinoma, Metastasis, Panhypopituitarism, Hospital Medicine

Abstract

Metastasis is a common complication of malignancy, however, researchers are constantly investigating and trying to better understand the way and pattern in which cancer spreads. Neuro-ophthalmologic and ocular presentations are rare in cholangiocarcinoma, with only one known confirmed case reported in 2020. This case features a patient with a known diagnosis of cholangiocarcinoma with bone metastasis; complicated by newly discovered subdural hematoma and suspected pituitary metastasis; with radiological evidence of abnormally large and enhancing pituitary, clinical features of left-sided cranial nerve 6th palsy and laboratory features of panhypopituitarism.

References

Castro FA, Koshiol J, Hsing AW, Devesa SS. Biliary tract cancer incidence in the United States-demographic and temporal varia-tions by anatomic site. Int J Cancer. 2013; 133(7): 1664-1671. doi: 10.1002/ijc.28161

Abou-Alfa GK. Cholangiocarcinoma - symptoms, causes, treat-ment: Nord. National Organization for Rare Disorders. https:// rarediseases.org/rare-diseases/cholangiocarcinoma/. Accessed December 24, 2022.

Nakeeb A, Pitt HA, Sohn TA, et al. Cholangiocarcinoma. An-nals of Surgery, 1996; 224(4): 463-475. doi: 10.1097/00000658- Submit your article to this journal | https://openventio.org/submit-manuscript/ Case Report | Volume 7 | Number 1 | Machani S, et al 199610000-00005

Gerstenmaier J. Intrahepatic cholangiocarcinoma. Radiopaedia. org. 2014; doi: 10.53347/rid-31274

Key statistics. Cholangiocarcinoma Foundation. https://cholan-giocarcinoma.org/key-statistics/2022. Retrieved October 6, 2022. Accessed December 24, 2022.

Sripa B, Pairojkul C. Cholangiocarcinoma: Lessons from Thai-land. Curr Opin Gastroenterol. 2008; 24(3): 349-356. doi: 10.1097/ mog.0b013e3282fbf9b3

Fowler BJ, Lam BL. Sixth cranial nerve palsy as the presenting sign of metastatic cholangiocarcinoma. Int Med Case Rep J. 2020; 13: 667-671. doi: 10.2147/imcrj.s272818

Cancer.Net®. Bile duct cancer (cholangiocarcinoma): Coping with treatment. https://www.cancer.net/cancer-types/bile-duct-cancer-cholangiocarcinoma/coping-with-treatment. Retrieved October 15, 2022. Accessed December 24, 2022.

Downloads

Published

2023-08-04

How to Cite

Emilia Surzyn, & Sathyanarayana Machani. (2023). Rare Case of Metastatic Cholangiocarcinoma leading to Panhypopituitarism. Internal Medicine, 7(1), 1–3. https://doi.org/10.17140/IMOJ-7-122