Effect of Diethylenetriaminepentaacetic Acid (DTPA) on Crystal Growth and Morphology of Calcium Oxalate

Abstract

Introduction: One of the most common and painful diseases observed in the tropical regions
is kidney stone formation. This can be due to various factors such as the amount of water
consumption, climatic conditions, lifestyle and diet. Although, kidney stones are composed of
calcium phosphate were only found to be 10%, it has been observed that the deposition of such
stones have been increasing steadily for the past 30 years in females.
Aim: To study the effects of diethylenetriaminepentaacetic acid (DTPA) on crystal growth and
morphology of calcium oxalate.
Materials and Methods: Calcium oxalate was synthesized from calcium chloride solution using
oxalic acid in the presence of DTPA at different concentrations. The experiments were carried
out at 60 °C. The samples were characterized using powder X-ray diffraction analysis (XRD),
Fourier transform infrared spectroscopy (FTIR) and scanning electron microscope (SEM) techniques.
Results: The study revealed that in the absence of DTPA, samples exhibited flower like morphology by agglomeration of rod like basic blocks and the tendency for agglomeration decreases with increase in DTPA concentration.
Conclusion: Interpretation of XRD pattern confirmed that whewellite with a monoclinic structure is the most favoured structure in the absence of DTPA where as calcium oxalate hydrate
having orthorhombic structure is most favoured structure in the presence of DTPA