The Unfolded Protein Response: A Novel Insight into Chronic Kidney Disease (CKD)

Abstract

Chronic kidney disease (CKD) is a clinical syndrome, characterized by a progressive decline of renal function. CKD is associated with a wide range of metabolic abnormalities including hypertension, anemia, acidosis, and mineral bone diseases.1
The progression of
CKD may lead to end-stage renal diseases. CKD affects nearly 500 million people worldwide
and thus has become a global public health concern. While the pathogenesis of CKD remains
poorly understood, accumulating studies have revealed that the endoplasmic reticulum (ER)
stress contributes to the onset and progression of CKD including renal fibrosis, which can lead
to end-stage renal disease, independent of the original cause of CKD