The Unfolded Protein Response: A Novel Insight into Chronic Kidney Disease (CKD)

Authors

  • Zijun Liu, MD, PhD
  • Na Liu, MD
  • Shi-Bin Cheng, MD, PhD

Keywords:

accumulating, pathogenesis, abnormalities

Abstract

Chronic kidney disease (CKD) is a clinical syndrome, characterized by a progressive decline of renal function. CKD is associated with a wide range of metabolic abnormalities including hypertension, anemia, acidosis, and mineral bone diseases.1
The progression of
CKD may lead to end-stage renal diseases. CKD affects nearly 500 million people worldwide
and thus has become a global public health concern. While the pathogenesis of CKD remains
poorly understood, accumulating studies have revealed that the endoplasmic reticulum (ER)
stress contributes to the onset and progression of CKD including renal fibrosis, which can lead
to end-stage renal disease, independent of the original cause of CKD

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Published

2017-08-28

How to Cite

Zijun Liu, MD, PhD, Na Liu, MD, & Shi-Bin Cheng, MD, PhD. (2017). The Unfolded Protein Response: A Novel Insight into Chronic Kidney Disease (CKD). Nephrology, 15–17. Retrieved from https://openventio.us/index.php/NOJ/article/view/2290

Issue

Volume 3 Issue 1 2017

Section

Articles

License

All content published in Nephrology – Open Journal (NOJ) is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license allows anyone to copy, distribute, transmit, and adapt the work — including for commercial purposes — provided appropriate credit is given to the original author(s) and source.

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