Principles and Applications of Deoxyribonucleic Acid Microarray: A Review

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Authors

  • Haben Fesseha Department of Veterinary Surgery and Diagnostic Imaging, School of Veterinary Medicine,Wolaita Sodo University, P. O. Box 138,Wolaita Sodo, Ethiopia
  • Hiwot Tilahun College of Veterinary Science, Mekelle University, P. O. Box 2084, Mekelle, Ethiopia

DOI:

https://doi.org/10.17140/PLMOJ-3-109

Keywords:

Application, DNA, Microarray, Principle

Abstract

Deoxyribonucleic acid (DNA) microarrays are collections of DNA probes arranged on a base pair and the latest commercialized
molecular diagnostic technologies that offer high throughput results, more sensitive and require less time. It is the most reliable
and widely accepted tool facilitating the simultaneous identification of thousands of genetic elements even a single gene. Microarrays
are powerful new tools for the investigation of global changes in gene expression profiles in cells and tissues. The different
types of DNA microarray or DNA chip devices and systems are described along with their methods of fabrication and their
use. The DNA microarrays assembly process is automatized and further miniaturized. DNA microarrays are used in the search
of various specific genes or in gene polymorphism and expression analysis. They will be widely used to investigate the expression
of various genes connected with various diseases in order to find the causes of these diseases and to enable their accurate treatment.
Generally, microarray analysis is not only applied for gene expression studies, but also used in immunology, genotyping,
diagnostics and sequence analysis. Additionally, microarray technology being developed and applied to new areas of proteomics,
cancer research, and cellular analysis.

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Published

2020-01-20

How to Cite

Haben Fesseha, & Hiwot Tilahun. (2020). Principles and Applications of Deoxyribonucleic Acid Microarray: A Review. Pathology and Laboratory Medicine, 3(1), 1–9. https://doi.org/10.17140/PLMOJ-3-109