Palliative Care for Nephropathic Patients
DOI:
https://doi.org/10.17140/PMHCOJ-1-104Keywords:
Palliative care, Hospice care, Chronic Kidney Disease, End-Stage Renal Disease, Acute Kidney Injury, Renal Replacement TherapyAbstract
A new light has recently been shed on palliative care, especially, on its multidisci-plinary approach developed to improve the Quality of life of seriously ill patients and their families. However, palliative care is still often mistakenly referred to as an end-of-life care and wrongly interchanged with hospice care. Nephropathic patients usually present a decrease in expectancy and Quality of life and may benefit from palliative care as opposed to hospice care. Palliative care requires a tight collaboration among different health care professionals, patients and their families, to share diagnosis, prognosis, realistic goals of treatment and therapeutic decisions. Several approaches may be attempted to improve the Quality of life of chronic neph-ropathic patients, such as palliative dialysis, conservative management and peritoneal dialysis. For example, personalized goals and a wider concept of adequacy of extracorporeal treatment are the bases of palliative dialysis. In specific subgroups of frail patients, the pharmacological conservative management could be more appropriate than extracorporeal treatment, as the for-mer reduces the burdens derived from invasive procedures. Finally, peritoneal dialysis could be an important option for frail patients to avoid an aggressive extracorporeal treatment while maintaining a gentle solute and fluid control. However, only limited evidences are available on palliative and hospice care performed on patients with Acute Kidney Injury (AKI). Herein, the main variables affecting the medical decision-making on palliative care in nephropathic patients are described, and the different approaches available to improve quality of palliative care during Chronic and Acute Kidney Injury are analyzed.
References
Aslakson RA, Curtis JR, Nelson JE. The changing role of pal-liative care in the ICU. Crit Care Med. 2014; 42: 2418-2428. doi: 10.1097/CCM.0000000000000573
Parikh R, Kirch R, Smith T, Temel J. Early specialty palliative care-translating data in oncology into practice. N Eng J Med. 2013; 369: 2347-2351. doi: 10.1056/NEJMsb1305469
Zamperetti N, Bellomo R, Ronco C. Bioethical aspects of end-of-life care. Eur J Anaesthesiol. 2008; 42: 51-57.
Greer J, Jackson V, Meier D, Temel J. Early integration of palliative care services with standard oncology care for patients with advanced cancer. CA Cancer J Clin. 2013; 63: 349-363. doi: 10.3322/caac.21192
Higginson I, Costantini M, Silber E, Burman R, Edmonds P. Evaluation of a new model of short-term palliative care for people severely affected with multiple sclerosis: a randomised fast-track trial to test timing of referral and how long the effect is maintained. Postgrad Med J. 2011; 87: 769-775.
Hauptman P, Havranek E. Integrating palliative care into heart failure care. Arch Intern Med. 2005; 165: 374-378. doi: 10.1001/ archinte.165.4.374
Brumley R, Enguidanos S, Jamison P, et al. Increased satisfac-tion with care and lower costs: results of a randomized trial of in-home palliative care. J Am Geriatr Soc. 2007; 55: 993-1000. doi: 10.1111/j.1532-5415.2007.01234.x
Moss A, Holley J, Davison S, et al. Palliative care. Am J Kid-ney Dis. 2004; 43: 172-173.
Douglas C, Murtagh F, Chambers E, Howse M, Ellershaw J. Symptom management for the adult patient dying with ad-vanced chronic kidney disease: a review of the literature and development of evidence-based guidelines by a United King-dom Expert Consensus. Palliat Med. 2009; 23: 103-110. doi:
1177/0269216308100247 10. Greaves C, Bailey E, Storey L, Nicholson A. Implementing end of life care for patients with renal failure. Nurs Stand. 2009; 23: 35-41.
Davison SN, Jhangri GS, Holley JL, Moss AH. Nephrolo-gists’ reported preparedness for end-of-life decision-making. Clin J Am Soc Nephrol. 2006; 1: 1256-1262. doi: 10.2215/ CJN.02040606
Holley JL, Davison SN, Moss AH. Nephrologists’ changing practices in reported end-of-life decision-making. Clin J Am Soc Nephrol. 2007; 2: 107-111. doi: 10.2215/CJN.03080906
Collins AJ, Kasiske B, Herzog C, et al. Excerpts from the United States Renal Data System 2006 Annual Data Report. Am J Kidney Dis. 2007; 49(1 Suppl 1): A6-A7: S1-S296. doi: http:// dx.doi.org/10.1053/j.ajkd.2006.11.019
Jager K, van Dijk P, Dekker F, et al. The epidemic of aging in renal replacement therapy: an update on elderly patients and their outcomes. Clin Nephrol. 2003; 60: 352-360.
Romano T, Palomba H. Palliative Dialysis: A Change of Per-spective. J Clin Med Res. 2014; 6: 234-238.
Cohen L, Germain M, Poppel D. Practical considerations in dialysis withdrawal: “to have that option is a blessing”. JAMA. 2003; 289: 2113-2120. doi: 10.1001/jama.289.16.2113
Hamer R, El Nahas A. The burden of chronic kidney disease. BMJ. 2006; 332: 563-564.
Kurella Tamura M, Covinsky K, et al. Functional status of el-derly adults before and after initiation of dialysis. N Engl J Med. 2009; 361: 1539-1547. doi: 10.1056/NEJMoa0904655
Weisbord SD, Carmody SS, Bruns FJ, et al. Symptom bur-den, quality of life, advance care planning and the potential value of palliative care in severely ill haemodialysis patients. Nephrol Dial Transplant. 2003; 18: 1345-1352. doi: 10.1093/ndt/gfg105
Parlevliet JL, Buurman BM, Pannekeet MMH, et al. Syste-matic comprehensive geriatric assessment in elderly patients on chronic dialysis: a cross-sectional comparative and feasibility study. BMC Nephrol. 2012; 13: 30. doi: 10.1186/1471-2369-13-
Davison S. End-of-life care preferences and needs: percep-tions of patients with chronic kidney disease. Clin J Am Soc Ne-phrol. 2010; 5: 195-204. doi: 10.2215/CJN.05960809
ERA-EDTA Registry. ERA-EDTA Registry Annual Report 2012. Academic Medical Center, Department of Medical Infor-matics, Amsterdam, The Netherlands. 2014.
Canaud B, Tong L, Tentori F, et al. Clinical practices and out-comes in elderly hemodialysis patients: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Clin J Am Soc Nephrol. 2011; 6: 1651-1662. doi: 10.2215/CJN.03530410
Okon T, Evans J, Gomez C, Blackhall L. Palliative edu-cational outcome with implementation of PEACE tool inte-grated clinical pathway. J Palliat Med. 2004; 7: 279-295. doi: 10.1089/109662104773709404
Murtagh F, Addington-Hall J, Edmonds P, et al. Symptoms in advanced renal disease: a cross-sectional survey of symptom prevalence in stage 5 chronic kidney disease managed without dialysis. J Palliat Med. 2007; 10: 1266-1276. doi: 10.1089/ jpm.2007.0017
Johansen KL, Chertow GM, Jin C, Kutner NG. Significance of frailty among dialysis patients. J Am Soc Nephrol. 2007; 18: 2960-2967. doi: 10.1681/ASN.2007020221
Bortz W. A Conceptual Framework of Frailty: A Review. J Gerontol A Biol Sci Med Sci. 2002; 57: 283-288. doi: 10.1093/ gerona/57.5.M283
Fried L, Tangen C, Walston J, et al. Frailty in older adults evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001; 56: M146-M157. doi: 10.1093/gerona/56.3.M146
Burns A, Davenport A. Maximum conservative management for patients with chronic kidney disease stage 5. Hemodial Int. 2010; 14: 32-37. doi: 10.1111/j.1542-4758.2010.00488.x
Smith C, Da Silva-Gane M, Chandna S, et al. evaluation of planned non-dialytic management in a cohort of patients with end-stage renal failure. Nephron Clin Pr. 2003; 95: 40-46. doi: 10.1159/000073708
François K, Bargman J. Evaluating the benefits of home-based peritoneal dialysis. Int J Nephrol Renov Dis. 2014; 7: 447- 455. doi: 10.2147/IJNRD.S50527
Covic A, Bammens B, Lobbedez T, et al. Educating end-stage renal disease patients on dialysis modality selection. Clin Kidney J. 2010; 3: 225-233. doi: 10.1093/ndt/gfq206
Moss AH. To dialyze or not: the patient with metastatic can-cer and AKI in the intensive care unit. Clin J Am Soc Nephrol. 2012; 7: 1507-1512. doi: 10.2215/CJN.02030212
Ostermann M, Chang RWS. Acute kidney injury in the in-tensive care unit according to RIFLE. Crit Care Med. 2007; 35: 1837-1843; quiz 1852.
Dennen P, Douglas IS, Anderson R. Acute kidney inju-ry in the intensive care unit: an update and primer for the in-tensivist. Crit Care Med. 2010; 38: 261-275. doi: 10.1097/ CCM.0b013e3181bfb0b5
Mehta R, PASCUAL M, Soroko S, et al. Spectrum of acute renal failure in the intensive care unit: the PICARD experien-ce. Kidney Int. 2004; 66: 1613-1621. doi: 10.1111/j.1523-1755- .2004.00927.x
Liaño F, Felipe C, Tenorio MT, et al. Long-term outcome of acute tubular necrosis: a contribution to its natural history. Kid-ney Int. 2007; 71: 679-686. doi: 10.1038/sj.ki.5002086
Uchino S, Kellum J, Bellomo R, et al. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA. 2005; 294: 813-818. doi: 10.1001/jama.294.7.813
Okon TR, Vats HS, Dart RA. Palliative medicine referral in patients undergoing continuous renal replacement therapy for acute kidney injury. Ren Fail. 2011; 33: 707-717. doi: 10.3109/0886022X.2011.589946
Johnson RF, Gustin J. Acute renal failure requiring renal re-placement therapy in the intensive care unit: impact on progno-stic assessment for shared decision making. J Palliat Med. 2011; 14: 883-889. doi: 10.1089/jpm.2010.0452
Draper H. Ethical aspects of withdrawing/withholding renal replacement therapies on patients in acute renal failure in an in-tensive care unit. EDTNA-ERCA J. 2002; S2: 39-42.
Patel S, Holley J. Withholding and withdrawing dialysis in the intensive care unit: benefits derived from consulting the re-nal physicians association/american society of nephrology clini-cal practice guideline, shared decision-making in the appropriate initiation of and with. Clin J Am Soc Nephrol. 2008; 3: 587-593. doi: 10.2215/CJN.04040907
Maynard S, Whittle J, Chelluri L, Arnold R. Quality of life and dialysis decisions in critically ill patients with acute renal failure. Intensive Care Med. 2003; 29: 1589-1593. doi: 10.1007/ s00134-003-1837-5
Van Niekerk L, Raubenheimer P. A point-prevalence survey of public hospital inpatients with palliative care needs in Cape Town, South Africa. S Afr Med J. 2014; 103: 138-141.
Sykes E, Cosgrove J. Acute renal failure and the critically ill surgical patient. Ann R Coll Surg Engl. 2007; 89: 22-29.
Price C. Resources for planning palliative and end-of-life care for patients with kidney disease. Nephrol Nurs J. 2003; 30: 649-656.
Granado C, Mehta R. Withholding and withdrawing renal support in acute kidney injury. Semin Dial. 2011; 24: 208-214.
Hartog CS, Peschel I, Schwarzkopf D, et al. Are written ad-vance directives helpful to guide end-of-life therapy in the in-tensive care unit? A retrospective matched-cohort study. J Crit Care. 2014; 29: 128-133. doi: 10.1016/j.jcrc.2013.08.024
Villa G, Di Maggio P, Baccelli M, Romagnoli S, De Gaudio AR. Outcome prediction models in end-of-life decison making. Trends Anaesth Crit Care. 2014; 4: 170-174.
Ricci Z, Ronco C, D’Amico G, et al. Practice patterns in the management of acute renal failure in the critically ill patient: an international survey. Nephrol Dial Transplant. 2006; 21: 690- 696. doi: 10.1093/ndt/gfi296
Overberger P, Pesacreta M, Palevsky PM, VA/NIH Acute Renal Failure Trial Network. Management of renal replacement therapy in acute kidney injury. a survey of practitioner prescri-bing practices. Clin J Am Soc Nephrol. 2007; 2: 623-630.
Gatward JJ, Gibbon GJ, Wrathall G, Padkin A. Renal repla-cement therapy for acute renal failure: a survey of practice in adult intensive care units in the United Kingdom. Anaesthesia. 2008; 63: 959-966. doi: 10.1111/j.1365-2044.2008.05514.x
Giannoni C, Chelazzi C, Villa G, De Gaudio AR. Organ dy-sfunction scores in ICU. Trends Anaesth Crit Care. 2013; 3: 89- 96. doi: 10.1016/j.tacc.2013.01.008
Frost L, Pedersen R, Hansen H. Prognosis in septicemia complicated by acute renal failure requiring dialysis. Scand J Urol Nephrol. 1991; 25: 307-310.
Hamel M, Phillips R, Davis R, et al. Outcomes and cost-ef-fectiveness of initiating dialysis and continuing aggressive care in seriously ill hospitalized adults. SUPPORT Investigators. Stu-dy to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. Ann Intern Med. 1997; 127: 195-202. doi: 10.7326/0003-4819-127-3-199708010-00003
Abosaif NY, Tolba YA, Heap M, Russell J, El Nahas AM. The outcome of acute renal failure in the intensive care unit ac-cording to RIFLE: model application, sensitivity, and predicta-bility. Am J Kidney Dis. 2005; 46: 1038-1048. doi: http://dx.doi. org/10.1053/j.ajkd.2005.08.033
Choi A, Li Y, Parikh C, Volberding P, Shlipak M. Long-term clinical consequences of acute kidney injury in the HIV-infected. Kidney Int. 2010; 78: 478-485. doi: 10.1038/ki.2010.171
Swaminathan M, Hudson C, Phillips-Bute B, et al. Impact of early renal recovery on survival after cardiac surgery-associated acute kidney injury. Ann Thorac Surg. 2010; 89: 1098-1104. doi: 10.1016/j.athoracsur.2009.12.018
Thakar C V, Quate-Operacz M, Leonard AC, Eckman MH. Outcomes of hemodialysis patients in a long-term care hospital setting: a single-center study. Am J Kidney Dis. 2010; 55: 300- 306. doi: 10.1053/j.ajkd.2009.08.021
Ahlström A, Tallgren M, Peltonen S, Räsänen P, Pettilä V. Survival and quality of life of patients requiring acute renal re-placement therapy. Intensive Care Med. 2005; 31: 1222-1228. doi: 10.1007/s00134-005-2681-6
Noble J, Simpson K, Allison M. Long-term quality of life and hospital mortality in patients treated with intermittent or continuous hemodialysis for acute renal and respiratory failure. Ren Fail. 2006; 28: 323-330.
Teno J, Lynn J, Wenger N, et al. Advance directives for se-riously ill hospitalized patients: effectiveness with the patient self-determination act and the SUPPORT intervention. SUP-PORT Investigators. Study to Understand Prognoses and Pre-ferences for Outcomes and Risks of Treatment. J Am Geriatr Soc.1997; 45: 500-507.
Galla J. Clinical practice guideline on shared decision-ma-king in the appropriate initiation of and withdrawal from dialy-sis. The Renal Physicians Association and the American Society of Nephrology. J Am Soc Nephrol. 2000; 11: 1340-1342.
Ishikawa H, Sakamoto J. Nondialytic Therapy for Elderly Patients in a Critical Care Setting. Case Rep Nephrol Urol. 2014; 4: 126-130.
Ryder-Lewis M. Going home from ICU to die: a celebration of life. Nurs Crit Care. 2005; 10: 116-121. doi: 10.1111/j.1362- 1017.2005.00117.x
The SUPPORT Investigators. A controlled trial to improve care for seriously ill hospitalized patients. The study to under-stand prognoses and preferences for outcomes and risks of treat-ments (SUPPORT). JAMA. 1995; 274: 1591-1598. doi: 10.1001/ jama.1995.03530200027032
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