BCG-Associated Osteomyelitis: A Case Report

Authors

  • Yuko Kobashi Department of Radiology, Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan KEYWORDS: BCG (Mycobacterium bovis BCG); Osteomyelitis; PCR (Polymerase Chain Reaction).
  • Yohei Munetomo Department of Radiology, Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan KEYWORDS: BCG (Mycobacterium bovis BCG); Osteomyelitis; PCR (Polymerase Chain Reaction).
  • Akira Baba Department of Radiology, Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan KEYWORDS: BCG (Mycobacterium bovis BCG); Osteomyelitis; PCR (Polymerase Chain Reaction).
  • Shinji Yamazoe Department of Radiology, Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan KEYWORDS: BCG (Mycobacterium bovis BCG); Osteomyelitis; PCR (Polymerase Chain Reaction).
  • Takuji Mogami Department of Radiology, Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan KEYWORDS: BCG (Mycobacterium bovis BCG); Osteomyelitis; PCR (Polymerase Chain Reaction).

DOI:

https://doi.org/10.17140/PNNOJ-3-117

Keywords:

BCG (Mycobacterium bovis BCG), Osteomyelitis; PCR (Polymerase Chain Reaction).

Abstract

BCG (Mycobacterium bovis BCG) is a vaccine for preventing childhood tuberculosis (TB).
The World Health Organization registered freeze-dried Tokyo-172 seed lot as an international
reference vaccine strain in 1965, and ever since, the Tokyo-172 BCG has been used, not only
in Japan, but also all over the world. However, there are some severe adverse reactions that
developed beyond vaccination site and regional ipsilateral axillary lymph-nodes. Osteomyelitis
is a very rare but serious late complication of BCG-immunization and results from generalized
dissemination of BCG.1 We present a case of a 23-month-old boy with a mass lesion in the right
shoulder.

 

References

Kwon HJ, Chung BH, Choi BM, Park KU, Kim YK. Severe osteomyelitis as a complication of Tokyo-172 BCG vaccination. J Korean Med Sci. 2012; 27(2): 221-224. doi: 10.3346/jkms. 2012.27.2.221

Ushio M. Amendment of tuberculosis prevention low and prospect of tuberculosis control program [In Japanese]. Kekkaku. 2005; 80(7): 541-546. doi: 10.11400/kekkaku1923.80.541

Toida I, Nakata S. Severe adverse reactions after vaccination with Japanese BCG vaccine: a review [In Japanese]. Kekkaku. 2007; 82(11): 809-824. doi: 10.11400/kekkaku1923.82.809

Norouzi S, Aghamohammadi A, Mamishi S, Rosenzweig SD, Rezaei N. Bacillus Calmette-Guérin (BCG) complications associated with primary immunodeficiency diseases. J Infect. 2012; 64(6): 543-554. doi: 10.1016/j.jinf.2012.03.012

Lee WI, Huang JL, Yeh KW, et al. Immune defects in active mycobacterial diseases in patients with primary immunodeficiency diseases (PIDs). J Formos Med Assoc. 2011; 110(12): 750-758. doi: 10.1016/j.jfma.2011.11.004

Hoshina T, Takada H, Sasaki Y, Kusuhara K, Hara T. Analysis of 27 patients with BCG osteomyelitis. The Journal of Pediatric Infectious Disease and Immunology. 2011; 23(3): 227-232. Web site. http://www.jspid.jp/journal/2011/023030227e.html. Accessed April 26, 2016.

Vasa M, Ohikhuare C, Brickner L. Primary sternal tuberculosis osteomyelitis: A case report and discussion. Can J Infect Dis Med Microbiol. 2009; 20(4): e181-e184. doi: 10.1155/2009/484712

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Published

2016-05-13

How to Cite

Yuko Kobashi, Yohei Munetomo, Akira Baba, Shinji Yamazoe, & Takuji Mogami. (2016). BCG-Associated Osteomyelitis: A Case Report. Pediatrics and Neonatal Nursing, 3(1), 6–8. https://doi.org/10.17140/PNNOJ-3-117

Issue

Vol. 3 No. 1 (2016): Volume 3 Issue 1 2016

Section

Articles

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All content published in Pediatrics and Neonatal Nursing (PNN) is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license allows anyone to copy, distribute, transmit, and adapt the work — including for commercial purposes — provided appropriate credit is given to the original author(s) and source.