β-cell Heterogeneity: The Key to β-cell Replacement Therapy
DOI:
https://doi.org/10.17140/POJ-2-e009Keywords:
insulin secreting β-cells, glucagon secret-ing α-cells, somatostatin secreting δ-cells, pancreatic polypeptide secreting PP-cells, and ghrelin secreting ε-cellsAbstract
Pancreatic islets of Langerhans are cell clusters that play a key role in glucose homeostasis. Among the five hormone secret-ingislet endocrine cells (insulin secreting β-cells, glucagon secret-ing α-cells, somatostatin secreting δ-cells, pancreatic polypeptide secreting PP-cells, and ghrelin secreting ε-cells), β-cells are special-ized glucose sensors that respond to increased insulin demand dur-ing physiological (i.e. pregnancy) or pathophysiological (i.e. type 2 diabetes) conditions.
References
Butler AE, Cao-Minh L, Galasso R, et al. Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy. Diabetologia. 2010; 53(10): 2167-2176. doi: 10.1007/ s00125-010-1809-6
Rieck S, Kaestner KH. Expansion of beta-cell mass in response to pregnancy. Trends Endocrinol Metab. 2010; 21(3): 151-158. doi: 10.1016/j.tem.2009.11.001
El Ouaamari A, Dirice E, Gedeon N, et al. Serpin B1 promotes pancreatic beta cell proliferation. Cell Metab. 2016; 23(1): 194-205. doi: 10.1016/j.cmet.2015.12.001
Hellerstrom C, Petersson B, Hellman B. Some properties of the B cells in the islet of Langerhans studied with regard to the posi-tion of the cells. Acta Endocrinol (Copenh). 1960; 34: 449-456. doi: 10.1530/acta.0.XXXIV0449
Salomon D, Meda P. Heterogeneity and contact-dependent regu-lation of hormone secretion by individual B cells. Exp Cell Res. 1986; 162(2): 507-520.
Avrahami D, Klochendler A, Dor Y, Glaser B. Beta cell hetero-geneity: An evolving concept. Diabetologia. 2017; 60(8): 1363-1369. doi: 10.1007/s00125-017-4326-z
Gutierrez GD, Gromada J, Sussel L. Heterogeneity of the pancreatic beta cell. Front Genet. 2017; 8-22. doi: 10.3389/ fgene.2017.00022
Liu JS, Hebrok M. All mixed up: defining roles for beta-cell subtypes in mature islets. Genes Dev. 2017; 31(3): 228-240. doi: 10.1101/gad.294389.116 Submit your article to this journal | https://openventio.org/submit-manuscript/ e11 Dirice E PUBLISHERS
Bader E, Migliorini A, Gegg M, et al. Identification of prolif-erative and mature beta-cells in the islets of Langerhans. Nature. 2016; 535(7612): 430-434. doi: 10.1038/nature18624
Johnston NR, Mitchell RK, Haythorne E, et al. Beta cell hubs dictate pancreatic islet responses to glucose. Cell Metab. 2016; 24(3): 389-401. doi: 10.1016/j.cmet.2016.06.020
Rui J, Deng S, Arazi A, Perdigoto AL, Liu Z, Herold KC. Beta cells that resist immunological attack develop during progression of autoimmune diabetes in NOD mice. Cell Metab. 2017; 25(3): 727-738. doi: 10.1016/j.cmet.2017.01.005
Wang YJ, Golson ML, Schug J, et al. Single-cell mass cytometry analysis of the human endocrine pancreas. Cell Metab. 2016; 24(4): 616-626. doi: 10.1016/j.cmet.2016.09.007
Dorrell C, Schug J, Canaday PS, et al. Human islets contain four distinct subtypes of beta cells. Nat Commun. 2016; 7:11756. doi: 10.1038/ncomms11756
Wang P, Alvarez-Perez JC, Felsenfeld DP, et al. A high-through-put chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication. Nat Med. 2015; 21(4): 383-388. doi: 10.1038/nm.3820
Dirice E, Walpita D, Vetere A, et al. Inhibition of DYRK1A stimulates human beta-cell proliferation. Diabetes. 2016; 65(6): 1660-1671. doi: 10.2337/db15-1127
Dhawan S, Dirice E, Kulkarni RN, Bhushan A. Inhibition of TGF-beta signaling promotes human pancreatic beta-cell replica-tion. Diabetes. 2016; 65(5): 1208-1218. doi: 10.2337/db15-1331
Bonner-Weir S, Inada A, Yatoh S, et al. Transdifferentiation of pancreatic ductal cells to endocrine beta-cells. Biochem Soc Trans. 2008; 36(Pt 3):353-356. doi: 10.1042/BST0360353
Pagliuca FW, Millman JR, Gurtler M, et al. Generation of func-tional human pancreatic beta cells in vitro. Cell. 2014; 159(2): 428- 439. doi: 10.1016/j.cell.2014.09.040
Xiao X, Guo P, Shiota C, et al. Endogenous reprogramming of alpha cells into beta cells, induced by viral gene therapy, re-verses autoimmune diabetes. Cell Stem Cell. 2018; 22(1): 78-90. doi: 10.1016/j.stem.2017.11.020 Editorial | Volume 2 | Number 1|
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
All content published in Pancreas (POJ) is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license allows anyone to copy, distribute, transmit, and adapt the work — including for commercial purposes — provided appropriate credit is given to the original author(s) and source.