The Evolving Field of Stereotactic Body Radiation Therapy in Pancreatic Cancer
Keywords:
Pancreatic neoplasms, Pancreas cancer; Radiosurgery, Stereotactic, Stereotactic body radiation therapy (SBRT)Abstract
Pancreatic cancer remains a devastating disease with dismal outcomes despite the development of novel chemotherapeutic regi
mens and radiation techniques. Stereotactic body radiation therapy (SBRT) offers an advantage both in image guidance and
radiation dose delivery to direct ablative doses to tumors with acceptable toxicity compared to conventional techniques. Recent
literature is clustered with data pertaining to SBRT in patients with resectable, borderline resectable and locally advanced pancre
atic tumors. We here present a summary of the current data and highlight the limitations and potential for future growth. Further
clinical study in the form of multi-institutional trials is warranted to establish the role of SBRT in combination with new chemo
therapeutic agents as well as a non-invasive alternative to surgery
