Primary Skeletal Muscle Lymphoma: A Case Report and Literature Review
DOI:
https://doi.org/10.17140/roj-7-139Keywords:
Extranodal lymphoma, Muscle lymphoma, Intramuscular mass, non-Hodgkin lymphoma (NHL)Abstract
Background
Lymphomatous involvement of the muscle is a rarely seen disorder, constituting 0.1-1.4% of all extranodal lymphomas. It may
be seen as the intramuscular involvement of disseminated disease, as an extension from adjacent bone or lymph nodes, or as
primary extranodal lymphoma. Primary lymphoma of the skeletal muscle mainly consists of B-cell non-Hodgkin lymphoma
(NHL) (>95%).
Case Presentation
A 50-year-old male patient presented with progressive swelling and pain in his right flank area over a period of one year. Ultrasound
(US) was done, and it showed diffuse enlargement of pelvic and limb muscles with hypoechoic regions that irregularly
infiltrated normal muscle tissue. An incisional biopsy was done, and the histopathologic diagnosis was diffuse large B-cell lymphoma
(DLBCL).
Conclusion
Primary intramuscular lymphoma is extremely rare. Nevertheless, it should be considered a differential diagnosis in patients
presenting with intramuscular tumors.
References
Shirzadi A. Diagnosis of B-cell lymphoma from gluteal mus-cle mass. Clin Case Reports. 2019; 7(7): 1316-1318. doi: 10.1002/ ccr3.2206
Ozturk M, Cinka H, Polat AV, Say F, Selcuk MB. Primary muscle lymphoma in an elderly patient: Ultrasound and mag-netic resonance imaging findings. 2019; 5(1): 1-3. doi: 10.5455/ ajdi.20181001021931
Burton E, Schafernak K, Morgan E, Samet J. Skeletal muscle involvement in B-cell lymphoma: Two cases illustrating the con-tribution of imaging to a clinically unsuspected diagnosis. Case Rep Radiol. 2017; 2017: 2068957. doi: 10.1155/2017/2068957
Choudhury J, Yalamanchili M, Friedenberg W. Skeletal mus-cle lymphoma. Med Oncol. 2002; 19(2): 125-129. doi: 10.1385/ mo:19:2:125
Bulgular MRG, Ba R. Primary Skeletal Muscle Lymphoma : Ul-trasound and MRI Findings. CausaPedia. 2013; 2: 286 1-7.
Campo E, Swerdlow SH, Harris NL, Pileri S, Stein H, Jaffe ES. The 2008 WHO classification of lymphoid neoplasms and beyond: Evolving concepts and practical applications. Blood. 2011; 117(19): 5019-5032. doi: 10.1182/blood-2011-01-293050
Akuzawa N, Hatori T, Takase A, Aoki J, Sakurai S, Kurabayashi M. Malignant lymphoma in the psoas major muscle. Case Rep He-matol. 2017; 2017: 3902748. doi: 10.1155/2017/3902748
Cases WJC. World Journal of Clinical Cases. WJCC, World J Clin Cases. 2021. Website. https://www.wjgnet.com/2307-8960. Ac-cessed February 1, 2024.
Jackson D, Ryan AG, Walsh E, et al. Musculoskeletal mani-festations of lymphoma: A case series. BJR Case Rep. 2022; 8(5): 20210182. doi: 10.1259/bjrcr.20210182
Hongsakul K, Laohawiriyakamol T, Kayasut K. A rare case of primary muscular non-Hodgkin’s lymphoma and a review of how imaging can assist in its diagnosis. Singapore Med J. 2013; 54(9): e179-e182. doi: 10.11622/smedj.2013179
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
All content published in Radiology (ROJ) is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license allows anyone to copy, distribute, transmit, and adapt the work — including for commercial purposes — provided appropriate credit is given to the original author(s) and source.