Testicular Adult Type Granulosa Cell Tumor: A Very Rare Case Report and Review of Literature

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Authors

  • Wei-Chieh Chen Department of Urology, Taipei Medical University Hospital, Taipei, Taiwan
  • Yun-Ho Lin Department of Dentistry, Taipei Medical University Hospital, Taipei, Taiwan; School of Dentistry, College of Oral Medicine, Taipei Medical University Hospital, Taipei, Taiwan
  • Shauh-Der Yeh Department of Urology, Taipei Medical University Hospital, Taipei, Taiwan
  • Chien-Chih Wu Department of Urology, Taipei Medical University Hospital, Taipei, Taiwan; Department of Urology, School of Medicine, Taipei Medical University, Taipei, Taiwan

DOI:

https://doi.org/10.17140/UAOJ-1-103

Keywords:

Testis tumor, Radical orchiectomy, Adult type granulosa cell tumor

Abstract

Granulosa Cell Tumors (GrCT) are rare sex cord-stromal neoplasms of the gonads and can be classified into adult and juvenile types. GrCT arise more commonly from the ovary than the testis; and juvenile type Granulosa Cell Tumors (jGrCT) are more prevalent among male than female. A review of the literature shows less than 50 reported cases of adult Granulosa Cell Tumor (aGrCT) and it is still an extremely rare type of testis tumors. We report an elderly male diagnosed of aGrCT in the left testis. Radical orchiectomy was performed and no further treatment. Pathology report confirmed GrCT. Immunoprofile of the tumor was vimentin (+), inhibin-alpha (+), Bcl-2 (+), calretinin (-), CLA (-), S-100 (-) and CD99 (-).

References

Miliaras D, Anagnostou E, Moysides I. Adult type granulosa cell tumor: a very rare case of sex-cord tumor of the testis with review of the literature. Case Rep Pathol. 2013; 932086: 1-4. doi: 10.1155/2013/932086

Hanson JA, Ambaye AB. Adult testicular granulosa cell tu-mor: a review of the literature for clinicopathologic predictors of malignancy. Arch Pathol Lab Med. 2011; 135(1): 143-146. doi: 10.1043/2009-0512-RSR.1

Song Z, Vaughn DJ, Bing Z. Adult type granulosa cell tumor in adult testis: report of a case and review of the literature. Rare Tumors. 2011; 3(4): e37. doi: 10.4081/rt.2011.e37

Young RH. Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems. Mod Pathol. 2005; 18: S81-S98. doi: 10.1038/mod-pathol.3800311

Mosharafa AA, Foster RS, Bihrle R, et al. Does retroperito-neal lymph node dissection have a curative role for patients with sex cord – stromal testicular tumors?” Cancer. 2003; 98(4): 753- 757. doi: 10.1002/cncr.11573

Jimenez-Quintero LP, Ro JY, Zavala-Pompa A, et al. Granu-losa cell tumor of the adult testis: a clinicopathologic study of seven cases and a review of the literature. Hum Pathol. 1993; 24(10): 1120-1126. doi: 10.1016/0046-8177(93)90193-K

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Published

2016-05-26

How to Cite

Wei-Chieh Chen, Yun-Ho Lin, Shauh-Der Yeh, & Chien-Chih Wu. (2016). Testicular Adult Type Granulosa Cell Tumor: A Very Rare Case Report and Review of Literature. Urology and Andrology , 1(1), 12–14. https://doi.org/10.17140/UAOJ-1-103

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