Review on Leptospirosis and its Public Health Significance
DOI:
https://doi.org/10.17140/VMOJ-6-159Keywords:
Leptospirosis; Zoonosis; Leptospira; Rodent.Abstract
Leptospirosis is the most widespread and most prevalent zoonotic disease caused by Leptospira bacteria this is pathogenic Gramnegative bacteria, the disease leptospirosis a zoonotic disease of global importance. It caused by various serovars of leptospira
interrogans that belong to the genus Leptospira. Besides leptospira interrogans is the most serovars like the disease occurs in nearly all
mammalian species. The highest burden in low-income both found in urban and in rural environments. Rodents are known as the
main reservoir animals, However, all animals are reservoir include human so leptospirosis is more common in the tropical regions
rather than subtropics because of the longer survival of the organism in the environment and frequent exposure of animals and
humans to contaminated environments. Direct transmission to humans by broken skin and mucous membranes exposed to the
urine of infected animals. While the clinical signs of leptospirosis do not vary greatly with the species of animals include laboratory tests. Control and prevention is sanitary measures, vaccination, quarantine and rodent control are the most important control
measures of the disease, require elimination of the carrier state, maintenance of environmental condition and immunization of
the animal, tropical areas where warm humid conditions and alkaline or neutral soil helps leptospira survive better.
References
Mwachui MA, Crump L, Hartskeerl R, Zinsstag J, Hattendore J. Environmental and behavioral determinants of leptospirosis transmission: A systematic review. PLoS Neglected Tropical Diseases. 2015; 9(9): e0003843. doi: 10.1371/journal.pnt d.0003843
Pappas G, Papadimitriou P, Siozopoulou V, Chistou L, Akritidis N. The globalization of leptospirosis; worldwide incidence trends. Int J Infect Dis. 2008; 12: 351-357. doi: 10.1016/j.ijid.2007.09.011
Smith RM, Zochowski WJ. Leptospirosis. In: Palmer SR, Solusby L, Torgerson PR, David WGB, eds. Zoonosis Biology, Clinical Practice, and Public Health Control. 2nd ed. NY, USA: Oxford University; 2011.
Robi DT. Epidemiology and zoonotic implication of leptospi-rosis in domestic animals in Ethiopia. Academic Journal of Animal Diseases. 2020; 9(1): 19-32. doi: 10.5829/idosi.ajad.2020.19.32
Tewodros F, Makash A. Leptospirosis and its public significance: A review. Eur J Appl Sci. 2012; 4(6): 238-244. doi: 10.5829/idosi. ejas.2012.4.6.66162
Pal M, Hadush A. Leptospirosis: An infectious emerging water-borne zoonosis of global significance. Air Water Borne Dis. 2017; 6: 133. doi: 10.4172/2167-7719.1000133
Ahmad SN, Shah S, Ahmad FM. Laboratory diagnosis of lepto-spirosis. J Postgrad Med. 2005; 51: 195-200.
Heymann DL. Control of Communicable Diseases, Manual. 18th ed. Washington, D.C., USA: American Public Health Association. 2004: 306-309. Review | Volume 6 | Issue 2 | Ame MM
Tilahun Z, Reta D, Simenew K. Global epidemiological over-view of leptospirosis. International Journal of Microbiology Research. 2013; 4(1): 9-15. doi: 10.5829/idosi.ijmr.2013.4.1.7134
Lucheis SB, Ferreira RS. Ovine leptospirosis in Brazil. Journal of Venomous Animals and Toxins including Tropical Diseases. 2011; 17(4): 394-405. doi: 10.1590/S1678-91992011000400006
Dhanze H, Suman MK, Mane B. Epidemiology of leptospiro-sis, An Indian perspective. Journal of Food Borne and Zoonotic Diseases. 2013; 1(1): 6-13.
Wang Y, Zhunang X, Zhong Y, et al. Distribution of plasmids in district leptospira pathogenic species. PLoS Negl Trop Dis. 2015; 9(11): e0004220. doi: 10.1371/journal.pntd.0004220
Shivakumar S. Leptospirosis-current scenario in India. In: Medi-cine Update. 2010; 18: 799-809. doi: 10.13140/2.1.4905.6968
Deanna H. Leptospirosis: A waterborne zoonotic disease of global importance. Georgia Epidemiology Report. 2006; 22: 8.
Doern G. Detection of selected fastidious bacteria. Clin Infect Dis. 2000; 30: 166-173. doi: 10.1086/313586
Plank R, Dean D. Overview of the epidemiology, microbiol-ogy and pathogenesis of Leptospira spp. in humans. Microbes Infect. 2000; 2(10): 1265-1276. doi: 10.1016/s1286-4579(00)01280-6
World Health Organization (WHO). Human Leptospirosis: Guidance for diagnosis, surveillance and control. 2003. Web site. https://www.who.int/publications/i/item/human-leptospirosis-guidance-for-diagnosis-surveillance-and-control. Accessed Ocoto-ber 12, 2021.
Fraser C, Norris S, Weinstock G. Complete genome sequence of Treponema pallidum, the syphilis spirochete. Science. 1998; 281: 375-388. doi: 10.1126/science.281.5375.375
Adler B, Moctezuma A. Leptospira and leptospirosis. Veterinary Microbiology. 2010; 140: 287-296. doi: 10.1016/j.vetmic.2009.03.012
Johnson RC, Faine S. Leptospira. In: Krieg NR, Holt JG, eds. Bergey's Manual of Systematic Bacteriology. Philadelphia, USA: Williams & Wilkins;1984; 1: 62-67.
Ajaj EA, AL-Farwachi MI. Detection of bovine leptospiro-sis using different conventional laboratory tests in Nineveh prov-ince, Iraq. J Anim Health Prod. 2013; 1(3): 32-35. doi: 10.13140/ RG.2.2.21052.69768
Evangelista KV, Coburn J. Leptospira as an emerging pathogen: A review of its biology, pathogenesis and host immune responses. Future Microbiol. 2010; 5(9): 1413-1425. doi: 10.2217/fmb.10.102
Costa F, Hagen JE, Calgano J, et al. Global morbidity and mor-tality of leptospirosis: A systematic review. PLoS Negl Trop Dis. 2015; 9: e0003898. doi: 10.1371/journal.pntd.0003898
Abela-Ridder B, Sikkema R, Hartskeerl R. Estimating the bur-den of human leptospirosis. Int J Antimicrob Agents. 2010; 36: 5-7. doi: 10.1016/j.ijantimicag.2010.06.012
Lau C, Smythe L, Craig S, Weinstein P. Climate change, flood-ing, urbanization and leptospirosis: Fueling the fire. Trans R Soc Trop Med Hyg. 2010; 104: 631-638. doi: 10.1016/j.trstmh.2010.07.002
Waktole Y, Bashahun G, Nejash A. Leptospirosis in animal and its public health implications: A review. World Appl Sci J. 2016; 34(6): 845-853. doi: 10.5829/idosi.wasj.2016.34.6.103113
Office International des Epizooties (OIE), 2005. Institute for International Cooperation in Animal Biology. Iowa State Univer-sity, College of Veterinary Medicine, Web site: http://www.cfs ph. IA state.edu. Accessed October 12, 2021.
Farrelly HE, Adler B, Faine S. Opsonic monoclonal antibod-ies against lipopolysaccharide antigens of leptospira interogans se-rovar hardjo. J Med Microbiol. 1987; 23: 1-7. doi: 10.1099/00222615- 23-1-1
Kohn B, Steinicke K, Arndt G, et al. Pulmonary abnormalities in dogs with leptospirosis. J Vet Intern Med. 2010; 24(6): 1277-1282. doi: 10.1111/j.1939-1676.2010.0585.x
Wasiński B, Dutkiewicz J. Leptospirosis—current risk factors connected with human activity and the environment. Ann Agric Environ Med. 2013; 20(2): 239-244.
Ellis WA. Animal leptospirosis. Curr Top Microbiol Immunol. 2015; 387: 99-137. doi: 10.1007/978-3-662-45059-8_6
World Health Organization (WHO). Report of the first meeting of the leptospirosis burden epidemiology Reference Group, WHO Library Cataloguing-in- Publication Data. Web site. http://apps. who.int/iris/bitstream/handle/10665/44382/9789241599894_ eng.pdf;jsessionid=C77D7B6387ED10A9A81F68CBE5C280D6? sequence=1. 2010: 1-34.
Levett PN. Systematics of leptospiraceae. In: Adler B, ed. Lep-tospira and Leptospirosis. Berlin: Springer; 2015: 11-20.
Radostits O, Gay C, Hinchcliff K, Constable P. Veterinary Medi-cine: A Textbook of the Diseases of Cattle, Horses, Sheep, Pigs and Goats. London, Saunders: Elsevier Health Sciences; 2006: 1094-1110.
Fentahun T, Alemayehu M. Leptospirosis and its public health significance: A review. Eur J Appl Sci. 2012; 4(6): 238-244.
Craig SB, Graham GC, Burns MA, Dohnt MF, Smythe LD, et al. Hematological and clinical-chemistry markers in patients pre-senting with leptospirosis: A comparison of the findings from un-complicated cases with those seen in the severe disease. Ann Trop Med Parasitol. 2009; 103: 333-341. doi: 10.1179/136485909X435058
Katz A, Ansdell V, Effler P, Middleton C, Sasaki D. Leptospiro-58 Ame MM sis in Hawaii, 1974-1998, epidemiologic analysis of 353 laboratory-confirmed cases. Am J Trop Med Hyg. 2002; 66: 61-70. doi: 10.4269/ ajtmh.2002.66.61
Langston, C, Heuter K. Leptospirosis, A re-emerging zoonotic disease. Vet Clin North Am Small Anim Pract. 2003; 33(4): 791-807. doi: 10.1016/s0195-5616(03)00026-3
Mohammed H, Nozha C, Hakim K, Abdelaziz F, Rekia B. Leptospira: Morphology, classification and pathogenesis. Jour-nal Bacteriology Parasitology, 2011; 2: 120. doi: 10.4172/2155- 9597.1000120
Mgode GF, Machang’u RS, Collares-Pereira M, et al. Challenges in determining the pathogenicity status of Leptospira isolates with phenotypic methods: The need for a polyvalent approach. African Journal of Microbiology Research. 2010; 4: 2528-2533.
Hirsh DC, Maclachlan NJ, Waller RL. Veterinary Microbiology. 2nd ed. NY, USA: Black Well; 2004: 148-152.
Haake DA, Levett PN. Leptospirosis in humans. Curr Top Micro-biol Immunol. 2015; 387: 65-97. doi: 10.1007/9 78-3-662-45059-8-5
Pal M. Zoo Noses. 2nd ed. Jaipur, India: Satyam Publishers; 2007.
Ajaj EAB, AL-Farwachi MI. Serosurvey of leptospira inter-rogans serovars hardjo and pomona in cattle in nineveh province, Iraq. Animal Health Prod and Hyg. 2013; 2(1): 156-158.
Ayyadevare S, Thaden JJ, Shmookler RJ. Discrimination of primer 39-nucleotide mismatch by taq DNA polymerase during polymerase chain reaction. Anal Biochem. 2000; 284: 11-18. doi: 10.1006/abio.2000.4635
Schreier S, Doungchawee G, Chadsuthi S, Triampo D, Triampo W. Leptospirosis: Current situation and trends of specific labo-ratory tests. Expert Rev Clinical Immunology. 2013; 9: 263-280. doi: 10.1586/eci.12.110
Musso D, La Scola B. Laboratory diagnosis of leptospiro-sis: A challenge. J Microbiol Immunol Infect. 2013; 46: 245-252. doi: 10.1016/j.jmii.2013.03.001
Draghi M, Brihuega B, Benitez D, Sala J, Biotti G, Pereyra M. Leptospirosis outbreak in calves from Corrientes Province, Ar-gentina. Rev Argent Microbiol. 2011; 43: 42-44. doi: 10.1590/S0325-
Mosby. Mosby's Medical Dictionary. 9th ed. Amsterdam, Nether-lands: Elsevier Health Sciences; 2013: 697.
Picardeau M, Bertherat E, Jancloes M, Skouloudis AN, Dur-ski K, Hartskeerl RA. Rapid tests for diagnosis of leptospirosis: current tools and emerging technologies. Diagn Microbiol Infect Dis. 2014; 78(1): 1-8. doi: 10.1016/j.diagmicrobio.2013.09.012
Mulla S, Chakra borty T, Patel M, Pandya HP, Dadhaniya V, Vaghela G. Diagnosis of leptospirosis and comparison of ELISA and MAT techniques. Indian J Pathol Microbiol. 2006; 49: 468-470.
Limmathurotsakul D, Turner EL, Wuthiekanun V, et al. Fool's gold: why imperfect reference tests are undermining the evalu-ation of novel diagnostics: A re-evaluation of 5 diagnostic tests for leptospirosis. Clinical Infectious Diseases. 2012; 55: 322-331. doi: 10.1093/ cid/cis403
Wasiński B, Pajsek Z. Occurrence of leptospiral infections in swine population in Poland evaluated by ELISA and microscopic agglutination test. Pol J Vet Sci. 2010; 3: 695-699. doi: 10.2478/ v10181-010-0006-3
Hirsh DC, Maclachlan NJ, Waller RL. Veterinary Microbiology. 2nd ed. NY, USA: Black Well; 2004: 148-152.
Chen H, Zhang Z, Halsey E, et al. Detection of Leptospira-Submit your article to this journal | https://openventio.org/submit-manuscript/ Review | Volume 6 | Issue 2 | Ame MM specific antibodies using a recombinant antigen-based enzyme-linked immunosorbent assay. Am J Trop Med Hyg. 2013; 89: 1088- 1094. doi: 10.4269/ajtmh.13-0041
Sabir M, Hatta M. Detection of IgM to leptospira agent with ELISA and leptodistick method. Bio Celebes. 2011; 5: 8-12.
Desakorn V, Wuthiekanun V, Thanachartwet V, et al. Accuracy of a commercial IgM ELISA for the diagnosis of human leptospi-rosis in Thailand. Am J Trop Med Hyg. 2012; 86: 524-527.
Guidugli F, Castro A, Atallah A. Antibiotics for leptospi-rosis. Cochrane Database Syst Rev. 2006; (2): CD008264. doi: 10.1002/14651858.CD008264.pub2
McBride AJA, Athanazio DA, Reis MG, Ko AI. Leptospi-rosis. Curr Opin Infect Dis. 2005; 18: 376-386. doi: 10.1097/01. qco.0000178824.05715.2c
Downloads
Published
How to Cite
Issue
Section
License

This work is licensed under a Creative Commons Attribution 4.0 International License.
All content published in Veterinary Medicine (VM) is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license allows anyone to copy, distribute, transmit, and adapt the work — including for commercial purposes — provided appropriate credit is given to the original author(s) and source.