Biomarkers for Oral Cancer: Is It a Pointless Game?
Keywords:
FOXM1, Exosomes, Salivary biomarker, Extracellular vesicles, Non-invasive diagnosis, Oral cancer, Saliva, Big data, Omics, Translational research, Clinical translationAbstract
There are forever new biomarkers discovered every now and then, claiming for their clinical diagnostic and prognostic potentials. When is it going to end or would it ever ends at all? During the preomics era, it used to be only a handful of protein markers with well-studied in-depth mechanism of actions.
References
Ledford H. Big science: The cancer genome challenge. Nature. 2010; 464(7291): 972-974. doi: 10.1038/464972a
Alyass A, Turcotte M, Meyre D. From big data analysis to personalized medicine for all: Challenges and opportunities. BMC Med Genomics. 2015; 8: 33. doi: 10.1186/s12920-015-0108-y
Teh MT. Is salivary exosome the answer to early detection of oral cancer? Dent Open J. 2015; 2(2): e3-e4. doi: 10.17140/DOJ-2-e002
Goding CR, Pei D, Lu X. Cancer: Pathological nuclear reprogramming? Nat Rev Cancer. 2014; 14(8): 568-573. doi: 10.1038/nrc3781
Guerrero-Preston R, Godoy-Vitorino F, Jedlicka A, et al. 16S rRNA amplicon sequencing identifies microbiota associated with oral cancer, human papilloma virus infection and surgical treatment. Oncotarget. 2016. doi: 10.18632/oncotarget.9710
Frediani JN, Fabbri M. Essential role of miRNAs in orchestrating the biology of the tumor microenvironment. Mol Cancer. 2016; 15(1): 42. doi: 10.1186/s12943-016-0525-3
Zhou W, Fong MY, Min Y, et al. Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis. Cancer Cell. 2014; 25(4): 501-515. doi: 10.1016/j.ccr.2014.03.007
Zhang L, Zhang S, Yao J, et al. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature. 2015; 527(7576): 100-104. doi: 10.1038/nature15376
Fong MY, Zhou W, Liu L, et al. Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis. Nat Cell Biol. 2015; 17(2): 183-194. doi: 10.1038/ncb3094
Alderton GK. Metastasis: Directions to metastatic sites. Nat Rev Cancer. 2015; 15(12): 696-697. doi: 10.1038/nrc4046
Hoshino A, Costa-Silva B, Shen TL, et al. Tumour exosome integrins determine organotropic metastasis. Nature. 2015; 527(7578): 329-335. doi: 10.1038/nature15756
Hashim D, Boffetta P, La Vecchia C, et al. The global decrease in cancer mortality: Trends and disparities.Ann Oncol. 2016; 27(5): 926-933. doi: 10.1093/annonc/mdw027
Collaborators GRF. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: A systematic analysis for the global burden of disease study 2013. Lancet. 2015; 386(9995): 743-800. doi: 10.1016/S0140-6736(15)60692-4
Zhou M, Wang H, Zhu J, et al. Cause-specific mortality for 240 causes in China during 1990-2013: A systematic subnational analysis for the global burden of disease study 2013. Lancet. 2016; 387(10015): 251-272. doi: 10.1016/S0140-6736(15)00551-6
Fitzmaurice C, Dicker D, Pain A, et al. The global burden of cancer 2013. JAMA Oncol. 2015; 1(4): 505-527. doi: 10.1001/jamaon-col.2015.0735
Hedberg ML, Goh G, Chiosea SI, et al. Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma. J Clin Invest. 2016; 126(4): 169-180. doi: 10.1172/JCI86862
Leemans CR, Braakhuis BJ, Brakenhoff RH. The molecular biology of head and neck cancer.Nat Rev Cancer. 2011; 11(1): 9-22. doi: 10.1038/nrc2982
D’Cruz AK, Vaish R, Kapre N, et al. Elective versus therapeutic neck dissection in node-negative oral cancer. N Engl J Med. 2015; 373(6): 521-529. doi: 10.1056/NEJMoa1506007
Zhang SK, Zheng R, Chen Q, Zhang S, Sun X, Chen W. Oral cancer incidence and mortality in China, 2011. Chin J Cancer Res. 2015; 27(1): 44-51. doi: 10.3978/j.issn.1000-9604.2015.01.03
de Juan J, Garcia J, Lopez M, et al. Inclusion of extracapsular spread in the pTNM classification system: A proposal for patients with head and neck carcinoma. JAMA Otolaryngol Head Neck Surg. 2013; 139(5): 483-488. doi: 10.1001/jamaoto.2013.2666
Baron RC, Melillo S, Rimer BK, et al. Intervention to increase recommendation and delivery of screening for breast, cervical, and colorectal cancers by healthcare providers a systematic review of provider reminders. Am J Prev Med. 2010; 38(1): 110-117. doi: 10.1016/j.amepre.2009.09.031
Teh MT. FOXM1 coming of age: Time for translation into clinical benefits?Front Oncol. 2012; 2: 146. doi: 10.3389/fonc.2012.00146
Teh MT, Hutchison IL, Costea DE, et al. Exploiting FOXM1-orchestrated molecular network for early squamous cell carcinoma diagnosis and prognosis. Int J Cancer. 2013; 132(9): 2095-2106. doi: 10.1002/ijc.27886
Teh M-T. Can challenges of oral cancer diagnosis be resolved? Dental Health: Current Research. 2015; 1: 1.
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