A Case Report of Solitary Adrenal Metastasis from Early Stage Endometrial Carcinoma

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Authors

  • Ladwa R
  • Crandon A
  • Coward J

DOI:

https://doi.org/10.17140/GOROJ-1-103

Keywords:

Endometrial cancer, Endometrioid adenocarcinoma, Adrenal metastasis

Abstract

Although Type I endometrial cancers are generally associated with a good prognosis, specific histopathological features portend worse outcomes. Compared to type II tumours which have increased metastatic potential, this phenomenon is seldom seen in type I counter parts at presentation. Moreover, adrenal metastatic sites are rarer still with only one case report describing this pattern of dissemination to date. To our knowledge this is the first case report of an isolated adrenal metastasis from early stage type I endometrial cancer and highlights the heterogeneity which exists in this disease.

References

Jemal A, Siegel R, Xu J, Ward E. Cancer statistics. CA Can-cer J Clin. 2010; 60(5): 277-300. doi: 10.3322/caac.21208

Lax SF, Pizer ES, Ronnett BM, Kurman RJ. Comparison of estrogen and progesterone receptor, Ki-67, and p53 immuno-reactivity in uterine endometrioid carcinoma and endometrioid carcinoma with squamous, mucinous, secretory, and ciliated cell differentiation. Hum Pathol. 1998; 29(9): 924-931.

Fujimoto T, Nanjyo H, Fukuda J, et al. Endometrioid uterine cancer: histopathological risk factors of local and distant recur-rence. Gynecol Oncol. 2009; 112(2): 342-347. doi: 10.1016/j. ygyno.2008.10.019

Lax SF, Pizer ES, Ronnett BM, Kurman RJ. Clear cell car-cinoma of the endometrium is characterized by a distinctive profile of p53, Ki-67, estrogen, and progesterone receptor ex-pression. Hum Pathol. 1998; 29(6): 551-558. doi: 10.1016/ S0046-8177

Hamilton CA, Cheung MK, Osann K, et al. Uterine papil-lary serous and clear cell carcinomas predict for poorer sur-vival compared to grade 3 endometrioid corpus cancers. Br J Cancer. 2006; 94(5): 642-646. doi: 10.1038/sj.bjc.6603012

Bremond A, Bataillard A, Thomas L, et al. Cancer of the endometrium. Br J Cancer. 2001; 84(Suppl 2): 31-36. doi: 10.1054/ bjoc.2001.1760

Baron M, Hamou L, Laberge S, Callonnec F, Tielmans A, Dessogne P. Metastatic spread of gynaecological neoplasms to the adrenal gland: case reports with a review of the literature. Eur J Gynaecol Oncol. 2008; 29(5): 523-526.

Izaki H, Takahashi M, Shiirevnyamba A, et al. Long-term recurrence-free survivor after laparoscopic removal of solitary adrenal metastasis from endometrial adenocarcinoma. J Med Invest. 2010; 57(1-2): 174-177.

Choi JJ, Buttrick S, Zakashansky K, Nezhat F, Chin EH. Laparoscopic adrenalectomy for isolated adrenal metastasis from cervical squamous cell carcinoma and endometrial ad-enocarcinoma. Gynecol Oncol. 2011; 122(3): 684-685. doi:

1016/j.ygyno.2011.05.030 10. Vassilopoulou-Sellin R, Schultz PN. Adrenocortical carci-noma. Clinical outcome at the end of the 20th century. Cancer. 2001; 92(5): 1113-1121.

Strong VE, D’Angelica M, Tang L, et al. Laparoscopic adrenalectomy for isolated adrenal metastasis. Ann Surg Oncol. 2007; 14(12): 3392-3400. doi: 10.1245/s10434-007-9520-7

Lo CY, van Heerden JA, Soreide JA, et al. Adrenalectomy for metastatic disease to the adrenal glands. Br J Surg. 1996; 83(4): 528-531.

Castillo OA, Vitagliano G, Kerkebe M, Parma P, Pinto I, Diaz M. Laparoscopic adrenalectomy for suspected metastasis of adrenal glands: our experience. Urology. 2007; 69(4): 637- 641. doi: http://dx.doi.org/10.1016/j.urology.2006.12.025

Straughn JM, Huh WK, Orr JW Jr, Kelly FJ, Roland PY, Gold MA, et al. Stage IC adenocarcinoma of the endometri-um: survival comparisons of surgically staged patients with and without adjuvant radiation therapy. Gynecol Oncol. 2003; 89(2): 295-300. doi: http://dx.doi.org/10.1016/S0090-8258- (03)00087-8

Creutzberg CL, van Putten WL, Warlam-Rodenhuis CC, et al. Outcome of high-risk stage IC, grade 3, compared with stage I endometrial carcinoma patients: the Postoperative Ra-diation Therapy in Endometrial Carcinoma Trial. J Clin Oncol. 2004; 22(7): 1234-1241. doi: 10.1200/JCO.2004.08.159

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Published

2014-11-17

How to Cite

Ladwa R, Crandon A, & Coward J. (2014). A Case Report of Solitary Adrenal Metastasis from Early Stage Endometrial Carcinoma. Gynecology and Obstetrics Research, 1(1), 8–11. https://doi.org/10.17140/GOROJ-1-103

Issue

Vol. 1 No. 1 (2014): Volume 1 Issue 1 2014

Section

Articles

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All content published in Gynecology and Obstetrics Research (GOR) is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license allows anyone to copy, distribute, transmit, and adapt the work — including for commercial purposes — provided appropriate credit is given to the original author(s) and source.