Endometrial Microbiota: A New Factor Affecting Endometrial Receptivity
Abstract
In the recent years, our knowledge about human reproductive system has increased with the development of assisted reproductive technologies; however, embryo implantation rate is still around 25-30%.1 Embryo implantation depends on the quality of the embryo, endometrial receptivity and the embryo/endometrial interface.2 The onset of implantation is a successful concurrence of 2 different processes; embryo development and endometrial differentiation.
References
Rashid NA, Lalitkumar S, Lalitkumar PG, Gemzell-Danielsson K. Endometrial receptivity and human embryo implantation. Am J Reprod Immunol. 2011; 66: 23-30. doi: 10.1111/j.1600-0897.2011.01048.x
Singh M, Chaudhry P, Asselin E. Bridging endometrial receptivity and implantation: Network of hormones, cytokines, and growth factors. J Endocrinol. 2011; 210: 5-14. doi: 10.1530/JOE-10-0461
Vilella F, Ramirez L, Berlanga O, et al. PGE2 and PGF2α concentrations in human endometrial fluid as biomarkers for embryonic implantation. J Clin Endocrinol Metab. 2013; 98: 4123-4132. doi: 10.1210/jc.2013-2205
Herington JL, Guo Y, Reese J, Paria BC. Gene profiling the window of implantation: Microarray analyses from human and rodent models. J Reprod Health Med. 2016; 2(Suppl 2): S19-S25. doi: 10.1016/j.jrhm.2016.11.006
Fan LJ, Han HJ, Guan J, et al. Aberrantly expressed long noncoding RNAs in recurrent implantation failure: A microarray related study. Syst Biol Reprod Med. 2017; 25: 1-10. doi: 10.1080/19396368.2017.1310329
Venter JC, Adams MD, Myers EW, et al. The sequence of the human genome. Science. 2001; 291: 1304-1351. doi: 10.1126/sci-ence.1058040
Relman DA, Falkow S. The meaning and impact of the human genome sequence for microbiology. Trends Microbiol. 2001; 9: 206-208. doi: 10.1016/S0966-842X(01)02041-8
Group NHW, Peterson J, Garges S, et al. The NIH human microbiome project. Genome Res. 2009; 19: 2317-2323. doi: 10.1101/ gr.096651.109
Franasiak JM, Werner MD, Juneau CR, et al. Endometrial microbiome at the time of embryo transfer: Next-generation sequencing of the 16S ribosomal subunit. J Assist Reprod Genet. 2016; 33: 129-136. doi: 10.1007/s10815-015-0614-z
Sender R, Fuchs S, Milo R. Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans. Cell. 2016; 164: 337-340. doi: 10.1016/j.cell.2016.01.013
Anderson JL, Edney RJ, Whelan K. Systematic review: Faecal microbiota transplantation in the management of inflammatory bowel disease. Aliment Pharmacol Ther. 2012; 36: 503-516. doi: 10.1111/j.1365-2036.2012.05220.x
Moayyedi P, Surette MG, Kim PT, et al. Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial. Gastroenterology. 2015; 149: 102-109(e1-e6). doi: 10.1053/j.gastro.2015.04.001
Romero R, Espinoza J, Mazor M. Can endometrial infection/inflammation explain implantation failure, spontaneous abortion, and preterm birth after in vitro fertilization? Fertil Steril. 2004; 82: 799-804. doi: 10.1016/j.fertnstert.2004.05.076
Moreno I, Codoñer FM, Vilella F, et al. Evidence that the endometrial microbiota has an effect on implantation success or fail-ure. Am J Obstet Gynecol. 2016; 215: 684-703. doi: 10.1016/j.ajog.2016.09.075
Franasiak JM, Scott RT. Reproductive tract microbiome in assisted reproductive technologies. Fertil Steril. 2015; 104: 1364- 1371. doi: 10.1016/j.fertnstert.2015.10.012
Browne HP, Forster SC, Anonye BO, et al. Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporu-lation. Nature. 2016; 533: 543-546. doi: 10.1016/j.cell.2016.01.013
Franasiak JM, Scott RT. Introduction: Microbiome in human reproduction. Fertil Steril. 2015; 104: 1341-1343. doi: 10.1016/j. fertnstert.2015.10.021
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