Carcinoid Heart Disease and Review of Literature

Crossmark: check for updates

Authors

  • Robin Fernandes Department of Internal Medicine, University of Illinois College of Medicine at Urbana Champaign, IL, USA
  • Srinivasan Sattiraju Department of Cardiology, Heart and Vascular Institute, Carle Foundation Hospital, IL, USA
  • Sanjay Mehta Department of Cardiology, Heart and Vascular Institute, Carle Foundation Hospital, IL, USA
  • Woubeshet Ayenew Department of Cardiology, Hennepin County Medical Center, MN, USA

DOI:

https://doi.org/10.17140/HROJ-4-132

Keywords:

Carcinoid heart disease (CHD), Neuroendocrine tumors (NETs), Valvular heart disease, Carcinoid syndrome

Abstract

Carcinoid Heart Disease (CHD) is one of the rare causes of acquired valvular heart disease.
CHD develops as a systemic manifestation of metastatic neuroendocrine tumors (NETs). When
these tumors metastasize to the liver, they can release vasoactive amines into the systemic circulation,
which can result in carcinoid syndrome and CHD. The key for diagnosing CHD is a
thorough history and physical examination supplemented with characteristic echocardiographic
findings. We report a case with classic echocardiographic features of CHD, which unfolded
the diagnosis of metastatic carcinoid tumor.

References

Modlin IM, Sandor A. An Analysis of 8305 cases of carcinoid tumors. Cancer. 1997; 79: 813-829. doi: 10.1002/(SICI)1097- 0142(19970215)79:4<813::AID-CNCR19>3.0.CO;2-2

Kulke MH, Mayer RJ. Carcinoid tumors. N Eng J Med. 1999; 340: 858-868. doi: 10.1056/NEJM199903183401107

Pellika PA, Tajik AJ, Khandheria BK, et al. Carcinoid heart disease: Clinical and echocardiographic spectrum in 74 pa-tients. Circulation. 1993; 87: 1188-1196. doi: 10.1161/01.CIR. 87.4.1188

Fox DJ, Khattar RS. Carcinoid heart disease: Presentation, diagnosis, and management. Heart. 2004; 90(10): 1224-1228. doi: 10.1136/hrt.2004.040329

Jonathan S, Gardner N, Kvols L. Survival and prognostic factor analysis of 146 metastatic neuroendocrine tumors of the mid-gut. Neuroendocrinology. 2009; 89(4): 471-476. doi: 10.1159/000197899

Waltenberger J, Lundin L, Oberg K, et al. Involvement of transforming growth factor-beta in the formation of fibrotic le-sions in carcinoid heart disease. Am J Pathol. 1993; 142(1): 71.

Jian B, Xu J, Connolly J, et al. Serotonin-induced up-regu-lation of transforming growth factor-β1 via G-protein signal transduction in aortic valve interstitial cells. Am J Pathol. 2002; 161(6): 2111-2121. doi: 10.1016/S0002-9440(10)64489-6

Møller JE, Connolly HM, Rubin J, Seward JB, Modesto K, Pellikka PA. Factors associated with progression of carcinoid heart disease. N Engl J Med. 2003; 348(11): 1005-1015. doi: 10.1056/NEJMoa021451

Simula DV, Edwards WD, Tazelaar HD, Connolly HM, Schaff HV. Surgical pathology of carcinoid heart disease: A study of 139 valves from 75 patients spanning 20 years. Mayo Clin Proc. 2002; 77(2): 139-147.

Connolly HM, Schaff HV, Mullany CJ, Rubin J, Abel MD, Pellikka PA. Surgical management of left-sided carcinoid heart disease. Circulation. 2001; 104(12 Suppl 1): I36-I40. doi: 10.1161/hc37t1.094898

Howard RJ, Drobac M, Rider WD, et al. Carcinoid heart dis-ease: diagnosis by two-dimensional echocardiography. Circula-tion. 1982; 66(5): 1059-1065. Web site. http://circ.ahajournals. org/content/circulationaha/66/5/1059.full.pdf. Accessed Sep-tember 5, 2016

Kvols LK, Moertel CG, O’Connell MJ, et al. Treatment of the malignant carcinoid syndrome. N Engl J Med. 1986; 315(11): 663-666. doi: 10.1056/NEJM198609113151102

Kvols LK. Metastatic carcinoid tumors and the carcinoid syndrome: A selective review of chemotherapy and hormonal therapy. Am J Med. 1986; 81(6): 49-55. doi: 10.1016/0002- 9343(86)90584-X

Lamberts SWJ. A guide to the clinical use of the soma-tostatin analogue SMS 201-995 (Sandostatin). Acta Endocri-nol (Copenh). 1987; 116(Suppl 4): S54-S66. doi: 10.1530/ acta.0.115S054

Martin JK, Moertel CG, Adson MA, Schutt AJ. Surgical treat-ment of functioning metastatic carcinoid tumors. Arch Surg. 1983; 118(5): 537-542. doi: 10.1001/archsurg.1983.01390050021004

Bernheim AM, Connolly HM, Rubin J, et al. Role of hepatic resection for patients with carcinoid heart disease. Mayo Clin Proc. 2008; 83(2): 143-150. doi: 10.4065/83.2.143

Møller JE, Pellikka PA, Bernheim AM, et al. Prognosis of Carcinoid heart disease analysis of 200 cases over two de-cades. Circulation. 2005; 112(21): 3320-3327. doi: 10.1161/ CIRCULATIONAHA.105.553750

Connolly HM, Nishimura RA, Smith HC, et al. Outcome of cardiac surgery for carcinoid heart disease. J Am Coll Cardiol. 1995; 25(2): 410-416. doi: 10.1016/0735-1097(94)00374-Y

Connolly HM, Schaff HV, Abel MD, et al. Early and late outcomes of surgical treatment in carcinoid heart disease. J Am Coll Cardiol. 2015; 66(20): 2189-2196. doi: 10.1016/j. jacc.2015.09.014

Downloads

Published

2016-09-15

How to Cite

Robin Fernandes, Srinivasan Sattiraju, Sanjay Mehta, & Woubeshet Ayenew. (2016). Carcinoid Heart Disease and Review of Literature. Heart Research, 4(1), 1–5. https://doi.org/10.17140/HROJ-4-132

Similar Articles

1 2 3 4 5 6 > >> 

You may also start an advanced similarity search for this article.