A Rare Case of BCGiosis With Severe Combined Immunodeficiency
DOI:
https://doi.org/10.17140/HARTOJ-2-106Keywords:
Disseminated tuberculosis, BCGiosis, Severe combined immunodeficiencyAbstract
Background: Bacille Calmette-Guerin (BCG), a live attenuated vaccine, is safe and given to all neonates in endemic countries; however may rarely cause disseminated disease, especially in immuno-deficient individuals.
Case characteristics: A 6 month old male infant, presented with vomiting, loose motions and failure to thrive. He was found to have features of severe acute malnutrition and abscess at BCG site. On investigations had features of disseminated tuberculosis in lung and skin and severe combined immunodeficiency.
Message: Infants with disseminated tuberculosis should be screened for underlying immunodeficiencies.
References
Paiman SA, Siadati A, Mamishi S, Tabatabaie P, Khotaee G. Disseminated Mycobacterium bovis infection after BCG vac-cination. Iran J Allergy Asthma Immunology. 2006; 5(3): 133- 137.
Talbot EA, Perkins MD, Silva SF, Frothingham R. Dis-seminated bacilli Calmette-Guerin disease after vaccination: case report and review. Clin Infect Dis. 1997; 24: 1139-1146. doi: 10.1086/513642
Talbot EA, Williams DL, Frothingham R. PCR identification of Mycobacterium bovis BCG. J Clin Microbiol. 1997, 35(3): 566.
Doffinger R, Dupuis S, Picard C, et al. Inherited disorders of IL-12- and IFN gamma-mediated immunity: a molecular ge-netics update. Mol Immunol. 2002; 38: 903-909. doi: 10.1016/ S0161-5890(02)00017-2 HIV/AIDS Res Treat Open J
Gonzalez B, Moreno S, Burdach R, et al. Clinical presentation of Bacillus Calmette-Guerin infections in patients with immu-nodeficiency syndromes. Pediatr Infect Dis J. 1989; 8(4): 201- 206.
Katzir Z, Okon E, Ludmirski A. Generalized Lymphadenitis following BCG vaccination in an immunocompetent 12 years old boy. Eur J Pediatr. 1984; 141(3): 165-170. doi: 10.1007/ BF00443216
Mohapatra S, Sethy S, Mohanty P, Mohapatra A, Pradhan S. Primary paediatric TH1 immunodeficiency with BCG-osis. International Journal of Case Reports and Images. 2012; 3(5). doi: 10.5348/ijcri-2012-05-123-CR-8
Lotte A, Wasz-Hockert O, Poisson N, et al. Second IUATLD study on complications induced by intradermal BCG-vaccina-tion. Bull Int Union of Tuberc. 1988; 63: 47-59.
Bacalhau S, Freitas C, Valente R, et al. successful handling of disseminated bcg disease in a child with severe combined immunodeficiency. Case Reports in Medicine. 2011; 2011: 527569. doi: 10.1155/2011/527569
Ikincioğullari A, Doğu F, Ciftci E, et al. An intensive ap-proach to the treatment of disseminated BCG infection in a SCID patient. Bone Marrow Transplant. 2002; 30(1): 45-47. doi: 10.1038/sj.bmt.1703578
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